Ramnik Xavier

The primary research goal of the Xavier Laboratory at Massachusetts General Hospital and the Broad Institute is to discover and understand the function of important mediators and effectors involved in both the innate and adaptive immune systems. Of particular interest are the cellular components and regulatory networks that interact dynamically within temporal, spatial, and patho-physiological contexts of innate immunity. A second area of focus is to examine the pathway defects associated with genetic variants in inflammatory bowel disease and identify novel small molecules that interrupt signal transduction pathways associated with disease risk. We are pursuing integrative systems approaches that closely couple genome-wide experimentation with high-throughput assays and computational methods. Furthermore, we are pursuing studies of the microbiome in autoimmunity and inflammatory bowel disease.

• Elected Member, American Association of Physicians
• Senior Associate Member, Broad Institute of MIT and Harvard
• Principal Investigator, Center for Computational and Integrative Biology

Clinical Interests

• Ulcerative colitis
• Crohn's disease
• Celiac disease
• Hepatitis
• Autoimmune disorders of the GI tract
• Gastrointestinal cancer

Medical Education

• PhD, University of Groningen - Netherlands
• MD, University of Zimbabwe School of Medicine
• Residency, Massachusetts General Hospital
• Fellowship, Massachusetts General Hospital

Board Certifications

Gastroenterology

Select Publications:

• Xavier RJ, Podolsky DK. Unraveling the pathogenesis of IBD. Nature 2007 Jul 26; 448(7152):427-34.
• Khor B, Gardet A, Xavier RJ. Genetics and pathogenesis of inflammatory bowel disease. Nature 2011 Jun 15; 474(7351):307-17.