Xiaowen Liu

Dr. Liu’s research is focused on human nutritional and metabolic dysfunction in the critically ill patients. After completing 6 years of the Interdepartmental Graduate Program in Nutritional Sciences and statistics in university of Wisconsin- Madison, and 3.5 years of postdoctoral training in endocrinology at Beth Israel Deaconess Medical Center, Harvard Medical School, Dr. Liu has developed an area of expertise in basic science research, biostatistics and data analysis which is critical for success in translational research. After completion of my post-doctoral training, I became the Lab Director at the Center for Resuscitation Science in BIDMC, which is a multi-disciplinary group of investigators focused on translational research with an emphasis on metabolic and mitochondrial dysfunction in the critically ill. As laboratory director I am providing an excellent bridge between clinical investigation and basic science. My research on immunocapture and microplate-based activity and quantity measurement of pyruvate dehydrogenase in human peripheral blood mononuclear cells set is a novel, easy and less invasive way to further understand the role of PDH, a key enzyme linking the glycolysis metabolic pathway to the citric acid cycle and releasing energy via NADH, in human disease. My current work is focused on evaluating mitochondrial and metabolic dysfunction across a range of critical illness and the response to potential metabolic resuscitators both in the lab and clinical setting.

Education

• PhD University of Wisconsin-Madison (2002 — 2008)
• Master of Science (MS) Sichuan University (1999 — 2002)
• Bachelor's degree Sichuan University (1995 — 1999)

Latest Publications

• Fagerberg SK, Patel P, Andersen LW, Lui X, Donnino MW, Praetorius HA. Erythrocyte P2X1 receptor expression is correlated with change in haematocrit in patients admitted to the ICU with blood pathogen-positive sepsis. Crit Care. 2018 Aug; 22(1):181.
• Holmberg MJ, Uber A, Stankovic N, Chen CO, Grossestreuer AV, Donnino MW, Andersen LW, Liu X. Ubiquinol (Reduced Coenzyme Q10) and Cellular Oxygen Consumption in Patients Undergoing Coronary Artery Bypass Grafting. J Intensive Care Med. 2018 Jan:[Epub ahead of print].
• Liu X, Montissol S, Uber A, Ganley S, Grossestreuer AV, Berg K, Heydrick S, Donnino MW. The Effects of Thiamine on Breast Cancer Cells. Molecules. 2018 Jun; 23(6).
• Chase M, Cocchi MN, Liu X, Andersen LW, Holmberg M, Donnino MW. Coenzyme Q10 in Acute Influenza. Influenza Other Respir Viruses. 2018 Aug: [Epub ahead of print].
• Donnino MW, Liu X, Andersen LW, Rittenberger JC, Abella BS, Gaieski D, Ornato J, Gazmuri RJ, Grossestreuer AV, Cocchi MN, Abbate A, Uber A, Clore J, Peberdy MA, Callaway CW. Characterization of Mitochondrial Injury after Cardiac Arrest (COMICA). Resuscitation. 2017 Apr;113:56-62.