Bin Wu

Education

• School of Biological Sciences, Nanyang Technological University, Singapore
• Ph.D. in Biochemistry, Biophysics and Structural Biology, 2006.07-2010.02
• B.Sc. in Biological Sciences, 2002.07-2006.06

Professional Experience

• Nanyang Assistant Professor, School of Biological Sciences, NTU 2015.03-present
• Charles A. King Research fellow Harvard Medical School & Boston Children’s Hospital 2013.10-2015.02
• GSK-IDI Research fellow Harvard Medical School 2010.02-2013.09

Research Interests

Auto-immune diseases are often caused by mis-regulated innate immune responses. The recent discoveries of a collection of innate immune receptors and their downstream adaptors provided us with the unprecedented opportunities to investigate and tackle the related diseases. However, at the moment, the effort of developing related therapies is largely prohibited by a lack of knowledge of molecular information of the key components of the signaling pathways.

Based on my previous success and experience in characterizing MDA5 and RIG-I, two cellular viral RNA sensors in innate immunity, I propose to investigate their downstream adaptor protein, MAVS, and other related innate immune signaling pathways. I plan to employ a combination of biophysical, biochemical and cellular methodologies to achieve my research goals.

I encourage undergraduate and graduate students sending in enquiries about opportunities performing cutting-edge research in molecular immunology. There are also Project Officer positions available.

Current Grants

• Activable Imaging Probes for Early Detection of Skin Allograft Rejection
• Determining the molecular and structural basis for inflammasome activation in human (OFIRG19may-0073)

Articles (Journal)

Y Deng, T Wu, M Wang, S Shi, G Yuan, X Li, H Chong, B Wu, P Zheng. (2019). Enzymatic biosynthesis and immobilization of polyprotein verified at the single-molecule level. Nature Communications, 10(1), 1-11.

MUSTAFA FAZLI, Morten Rybtke, Elisabeth Steiner, Elisabeth Weidel, JENS BERTHELSEN, Julie Groizeleau, Wu Bin, Boo Zhao Zhi, Zhang Yaming, Volkhard Kaever, MICHAEL GIVSKOV, Rolf Hartmann, Leo Eberl, TIM TOLKERNIELSEN. (2017). Regulation of Burkholderia cenocepacia biofilm formation byRpoN and the c-di-GMP effector BerB. MicrobiologyOpen, .

Wu B, Peisley A, Tetrault D, Li Z, Egelman EH, Magor K, Thomas Walz T, Penczek P, Hur S. (2014). Molecular imprinting as a signal activation mechanism of the viral RNA sensor RIG-I. Molecular Cell, 55(4), 511-23.

Peisley A, Wu B, Hui X, Chen ZJ and Hur S. (2014). Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I. Nature, 509, 110-114.

Peisley A*, Wu B*, Yao H, Walz T and Hur S. (2013). RIG-I forms signaling-competent filaments in an ATP-dependent and ubiquitin-independent manner. Molecular Cell, 51(5), 573-83.