Dongwon Lee

Dongwon Lee’s research focuses on discovering the genomic basis of pediatric kidney diseases from the perspective of transcriptional regulation in a cell-type-resolved manner. Dongwon has developed several computational methods based on machine-learning techniques and epigenomics data to predict cis-regulatory elements (CREs) and CRE variants from their primary DNA sequences. He demonstrated that the CRE variants predicted by these methods significantly contribute to the heritability of human traits and diseases in a tissue-specific way. He will extend these methodologies and develop new methods to build a unified framework that can illuminate the transcriptional regulatory network.

Dongwon Lee received his PhD from the Department of Biomedical Engineering at the Johns Hopkins University in 2013 and completed postdoctoral research at the Center for Human Genetics and Genomics at NYU School of Medicine.

Publications

Sequence-based correction of barcode bias in massively parallel reporter assays. Genome Res. 2021 09; 31(9):1638-1645. ViewSequence-based correction of barcode bias in massively parallel reporter assays.

Analysis of putative cis-regulatory elements regulating blood pressure variation. Hum Mol Genet. 2020 07 21; 29(11):1922-1932. ViewAnalysis of putative cis-regulatory elements regulating blood pressure variation.

Common risk variants in NPHS1 and TNFSF15 are associated with childhood steroid-sensitive nephrotic syndrome. Kidney Int. 2020 11; 98(5):1308-1322. ViewCommon risk variants in NPHS1 and TNFSF15 are associated with childhood steroid-sensitive nephrotic syndrome.

Multiple SCN5A variant enhancers modulate its cardiac gene expression and the QT interval. Proc Natl Acad Sci U S A. 2019 05 28; 116(22):10636-10645. ViewMultiple SCN5A variant enhancers modulate its cardiac gene expression and the QT interval.

Human cardiac cis-regulatory elements, their cognate transcription factors, and regulatory DNA sequence variants. Genome Res. 2018 10; 28(10):1577-1588.