Yoon Pin Lim

Affiliations

• Adjunct Assistant Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.
• Adjunct Scientist, Bioinformatics Institute, A * STAR.
• Adjunct Scientist, Singapore Eye Research Institute.
• Faculty, NUS Graduate School of Integrative Sciences and Engineering.
• Affiliate, National University Cancer Institute of Singapore.
• Teaching Faculty, Division of Graduate Medical Studies, Yong Loo Lin School of Medicine, NUS.

Education

• National University of Singapore 1990 – 1994
• Institute of Molecular and Cell Biology, A * STAR 1994 – 1999

Professional Experience

• Position and Institute Year(s)
• Dana-Farber Cancer Institute, Boston, USA 1999 – 2000
• National Cancer Centre of Singapore 2001 – 2004
• Oncology Research Institute/Cancer Science Institute 2005 – 2011

Research Interest

Lim Yoon Pin is one of pioneers to develop and apply cutting-edge liquid chromatography/mass spectrometry-based phosphoproteomic technologies to oncogenic signalling and cancer research. He has published more than 50 peer-reviewed articles in the area of signal transduction, cancer research and biomarker discovery. He has filed more than 30 patents, granted 11 patents from USA, China and Singapore while the rest are pending award. Four of his inventions are licensed to an MNC and SME. Through phosphoproteomics, he discovered WBP2, WW domain binding protein 2, to be a novel breast cancer associated protein and a substrate of the well-known EGF Receptor Tyrosine Kinase oncogene. Subsequently, he demonstrated WBP2 to be an oncogene that works by activating multiple oncogenic pathways such as Estrogen Receptor and Wnt signalling. His lab is expanding WBP2 research to other epithelial cancers and signalling pathways like Hippo signalling. Along with Hong Wanjin, Lim Yoon Pin is considered to be the first to prove WBP2 as a breast cancer oncogene. His lab’s efforts in WBP2 research and its impact on the Wnt and Hippo signalling are recognised internationally. He works with collaborators from Australia, Germany, USA and Singapore.

Lim Yoon Pin’s laboratory focuses on:

• Signal Transduction of RTKs, Wnt and Hippo pathways
• Epithelial Cancer Research
• Biomarker and Drug target Discovery
• Proteomics and Phosphoproteomics Technologies