Yixin Lu

Recognition and Achievements

• Fellow, Singapore National Academy of Science
• Editorial Advisory Board Member, Accounts of Chemical Research
• NRF Investigatorship Award 2018
• Asian Core Program Lectureship Award to Japan, Korea, China & Taiwan, 2009, 2011, 2012, 2014 & 2016
• Dean’s Chair Professorship, 2013
• GSK-SNIC Award in Organic Chemistry, 2013
• Outstanding Scientist Award & Young Scientist Award, Faculty of Science, NUS, 2013 & 2009
• Outstanding Chemist Award & Young Chemist Award, Department of Chemistry, NUS, 2011, 2010

Research Interests

Main areas of study are asymmetric catalysis/synthesis, & medicinal chemistry. Current interests include: asymmetric phosphine catalysis, asymmetric construction of axial chirality, photoredox-organo/transition metal cooperative catalysis, total synthesis, and transition metal catalysis.

Representative Publications

• Wu, Z.; Wu, M.; Zhu, K.; Wu, J.; Lu, Y., Photocatalytic coupling of electron-deficient alkenes using oxalic acid as a traceless linchpin. Chem 2023, 9,
• Tan, C. X. A.; Li, R.; Zhang, F.; Dai, L.; Ullah, N.; Lu, Y., Synthesis of Axially Chiral CF3-Substituted 2-Arylpyrroles by Sequential Phosphine-Catalyzed Asymmetric [3+2] Annulation and Oxidative Central-to-Axial Chirality Transfer. Angew. Chem. Int. Ed. 2022, 61,
• Huang, Q.; Chen, Y.; Zhou, X.; Dai, L.; Lu, Y., Nickel-Hydride-Catalyzed Diastereo- and Enantioselective Hydroalkylation of Cyclopropenes. Angew. Chem. Int. Ed. 2022, 61, DOI: 10.1002/anie.202210560.
• Dai, L.; Guo, J.; Huang, Q.; Lu, Y. “Asymmetric multifunctionalization of alkynes via photo-irradiated organocatalysis”, Sci. Adv., 2022, 8, eadd2574.
• Mei, G.-J.; Koay, W. L.; Guan, C.Y.; Lu, Y., Atropisomers beyond the C–C axial chirality: Advances in catalytic asymmetric synthesis. Chem 2022, 8, 1855.
• Zhang, F.; Dai, X.; Dai, L.; Zheng, W.; Chan, W.-L.; Tang, X.; Zhang, X.; Lu, Y., Phosphine-Catalyzed Enantioselective (3+2) Annulation of Vinylcyclopropanes with Imines for the Synthesis of Chiral Pyrrolidines. Angew. Chem. Int. Ed. 2022, 61, e202203212, DOI: 10.1002/anie.202203212.
• Mei, G.-J.; Wong, J. J.; Zheng, W.; Nangia, A. A.; Houk, K. N.; Lu, Y., Rational Design and Atroposelective Synthesis of N–N Axially Chiral Compounds. Chem 2021, 7, 2743.
• Zhang, F.; Zeng, J.; Gao, M.; Wang, L.; Chen, G.-Q.; Lu, Y.; Zhang, X., Concise, scalable and enantioselective total synthesis of prostaglandins. Nat. Chem. 2021, 13, 692.
• Mei, G.-J.; Koay, W. L.; Tan, C. X. A.; Lu, Y., Catalytic asymmetric preparation of pyrroloindolines: strategies and applications to total synthesis. Chem. Soc. Rev. 2021, 50, 5985.
• Chen, Y.; Zhu, L.; Huang, Q.; Lu, Y., Regiodivergent Sulfonylarylation of 1,3-Enynes via Nickel/Photoredox Dual Catalysis. Chem. Sci. 2021, 12, 13564.
• Wang, N.; Wu, Z.; Wang, J.; Ullah, N.; Lu, Y., Recent Applications of Asymmetric Organocatalytic Annulation Reactions in Natural Products Synthesis. Chem. Soc. Rev. 2021, 50, 9766.