Joseph Bonventre

Joseph V. Bonventre, MD, PhD is the Samuel A. Levine Distinguished Professor of Medicine, Constantine L. Hampers Distinguished Chair in Renal Medicine at Harvard Medical School, and Professor of Health Sciences and Technology at MIT. He is Chief of the Division of Renal Medicine of the Brigham and Women's Hospital (BWH) and also founding Chief of the Division of Engineering in Medicine at the BWH. He is former Director of the Harvard-MIT Division of Health Sciences and Technology. His studies kidney injury, adaptive and maladaptive repair and kidney regeneration, and includes inflammation, senescence, biomarkers, stem cells and kidney organoids. Bonventre has authored more than 400 original publications and 160 invited chapters and reviews, has received two MERIT awards from the NIH-NIDDK, and his work has been cited more than 82,000 times with an h-index of 143. He has been elected to the American Society of Clinical Investigation, the Association of American Physicians and the American Institute for Medical and Biological Engineering. He is a Fellow of the American Association for the Advancement of Science. He is the 4th most cited investigator in kidney and hypertension. Dr. Bonventre is Editor of Seminars in Nephrology, Osler Medal Awardee of the Royal Society of Physicians and Bywaters Awardee of the ISN, has a BS with distinction (Engineering Physics) from Cornell, an M.D. and Ph.D. (Biophysics) from Harvard, and Honorary doctorate degrees from Mt. Saint Mary's College and the Norwegian Institute of Science and Technology. He is past ASN Councilor and President and past ISN Councilor.

Education and Training

• B.S. with distinction 1970 (Engineering Physics)
  Cornell University
  Ithaca, NY

• M.D. 1976
  Harvard Medical School
  Harvard-MIT Division of Health Sciences and Technology
  Boston and Cambridge, MA

• Ph.D. 1979 (Biophysics)
  Harvard University
  Cambridge, MA

Research Interests

Dr. Bonventre’s research focuses primarily on the study of kidney injury and repair and signal transduction, with a special emphasis on the role of inflammation, biomarkers and stem cells.

SELECTED PUBLICATIONS

Yang L, Besschetnova TY, Brooks CR, Shah JV, Bonventre JV. Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med. 16(5):535-43, 2010. PMID: 20436483, PMC journal, in process

Vaidya VS, Ozer JS, Dieterle F, Collings FB, Ramirez V, Troth S, Muniappa N, Thudium D, Gerhold D, Holder DJ, Bobadilla NA, Marrer E, Perentes E, Cordier A, Vonderscher J, Maurer G, Goering PL, Sistare FD, Bonventre JV. Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies. Nat Biotechnol. 28(5):478-85, 2010. PMCID:PMC2885849

Bonventre JV, Vaidya VS, Schmouder R, Feig P, Dieterle F. Next-generation biomarkers for detecting kidney toxicity. Nat Biotechnol. 28(5):436-40, 2010. PMCID: PMC3033582

Humphreys BD, Czerniak S, DiRocco DP, Hasnain W, Cheema R, Bonventre JV. Repair of injured proximal tubule does not involve specialized progenitors. Proc Natl Acad Sci U S A. 108(22):9226-31, 2011. PMCID: PMC3107336

Waikar SS, Betensky RA, Emerson SC, Bonventre JV. Imperfect Gold Standards for Kidney Injury Biomarker Evaluation. J Am Soc Nephrol. 23(1):13-21, 2012. PMID: 22021710

Bonventre JV, Yang L. Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest. 121(11):4210-21, 2011. PMCID: PMC3204829