Jason Bruce

Biography

I am a lecturer in the Faculty of Life Sciences and am a member of the Cardiovascular & Metabolic Diseases Research Theme and Cell & Cancer Biology Research Theme. I predominantly teach Pharmacology and Physiology to undergraduate Science and Pharmacy students. Research in my laboratory focuses on the link between metabolism and cytosolic calcium signalling during pancreatitis and pancreatic cancer (see Research Interests).

I graduated from the University of Manchester with a BSc in Pharmacology and Physiology (1995) and then with a PhD in Physiology (1998). I spent a brief period (1998-1999) as a postdoc in the Department of Medicine here in Manchester working on the effects of hypoxia on vascular tone, prior to a move across the pond to the University of Rochester Medical Center, NY.  Here I worked as a postdoc and later as a Research Assistant Professor, where I developed an interest in signalling cross-talk in secretory epithelia which has formed the basis of some of my current research projects (see Research Interests).

I recently spent a research sabbatical working in the Department of Molecular and Integrative Medicine at the University of Michigan in collaboration with Prof John Williams. Here I learnt in vivo techniques and developed new models of pancreatitis combined with the hyperinsulinaemic euglycaemic clamp. This allows the administration of insulin during induction of pancreatitis while maintaining tight control of blood glucose.

Areas of expertise

• RM Therapeutics. Pharmacology - pancreatic cancer, pancreatitis, calcium signalling, metabolism, insulin, diabetes, calcium pumps, PMCA

Research Networks and Beacons

• Cancer

Biology, Medicine and Health (BMH) Domains

• Cancer
• Cardiovascular, Metabolic & Nutritional Sciences