Umar Sadat

Research Interests:

The ability to image pathobiology of atherosclerosis has been a fundamental driver of the paradigm shift in the way atherosclerosis is viewed today as a systemic inflammatory disease with an immunological basis. Imaging with techniques such as magnetic resonance imaging has allowed us to unravel the pathology of atherosclerosis and monitor efficacy of known and novel pharmacotherapies targeted at atherosclerosis. We have developed imaging platforms which allow morphological and functional assessment of atherosclerosis related-neovascularisation and inflammation. Significant body of work by the bioengineers within our group has allowed imaging based ex vivo and in vivo assessment of haemodynamic factors that influence atherosclerotic disease process. Our current focus is development of novel techniques that allow cellular imaging of mediators of atherosclerosis. Our bioengineering wing aims to analyse existing endovascular technologies such as aortic stents in terms of their effective durability with a view to develop the next generation of durable endovascular (bio)prosthesis.

Key Publications:

Usman A, Patterson AJ, Yuan J, Cluroe A, Patterson I, Graves MJ, Gillard JH, Sadat U. Ferumoxytol-enhanced three-dimensional magnetic resonance imaging of carotid atheroma- a feasibility and temporal dependence study. Sci Rep. 2020 Feb 4;10(1):1808.

Sadat U, Mariam NBG, Usman A, Chowdhury MM, El Nakhal T, DaCosta OF, Gillard JH, Hayes PD, Varty K. Association Between Abdominal Visceral Artery Calcification and All-Cause Mortality-A Computerized Tomography Imaging-Based Longitudinal Follow-Up Study. Angiology. 2019 Mar;70(3):237-243.

Sadat U, Jaffer FA, van Zandvoort MA, Nicholls SJ, Ribatti D, Gillard JH. Inflammation and neovascularization intertwined in atherosclerosis: imaging of structural and molecular imaging targets. Circulation. 2014 Aug 26;130(9):786-94.

Li ZY, Sadat U, U-King-Im J, Tang TY, Bowden DJ, Hayes PD, Gillard JH. Association between aneurysm shoulder stress and abdominal aortic aneurysm expansion: a longitudinal follow-up study. Circulation. 2010 Nov 2;122(18):1815-22.

Sadat U, Howarth SP, Usman A, Taviani V, Tang TY, Graves MJ, Gillard JH. Effect of low-and high-dose atorvastatin on carotid artery distensibility using carotid magnetic resonance imaging -a post-hoc sub group analysis of ATHEROMA (Atorvastatin Therapy: Effects On Reduction Of Macrophage Activity) Study. J Atheroscler Thromb. 2013;20(1):46-56.

Huang Y, Teng Z, Sadat U, Graves MJ, Bennett MR, Gillard JH.The influence of computational strategy on prediction of mechanical stress in carotid atherosclerotic plaques: comparison of 2D structure-only, 3D structure-only, one-way and fully coupled fluid-structure interaction analyses. J Biomech. 2014 Apr 11;47(6):1465-71.

Wang S, Zhang Y, Feng J, Huang Y, Tokgoz A, Sadat U, Gillard JH, Lu Q, Teng Z. Influence of overlapping pattern of multiple overlapping uncovered stents on the local mechanical environment: A patient-specific parameter study. J Biomech. 2017 Jul 26;60:188-196.

Sadat U, Taviani V, Patterson AJ, Young VE, Graves MJ, Teng Z, Tang TY, Gillard JH. Ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging of abdominal aortic aneurysms–a feasibility study. Eur J Vasc Endovasc Surg. 2011 Feb;41(2):167-74.

Sadat U, Teng Z, Young VE, Walsh SR, Li ZY, Graves MJ, Varty K, Gillard JH. Association between biomechanical structural stresses of atherosclerotic carotid plaques and subsequent ischaemic cerebrovascular events–a longitudinal in vivo magnetic resonance imaging-based finite element study. Eur J Vasc Endovasc Surg. 2010 Oct;40(4):485-91.

Sadat U, Walsh SR, Norden AG, Gillard JH, Boyle JR. Does oral N-acetylcysteine reduce contrast-induced renal injury in patients with peripheral arterial disease undergoing peripheral angiography? A randomized-controlled study. Angiology. 2011 Apr;62(3):225-30.

Sadat U, Weerakkody RA, Bowden DJ, Young VE, Graves MJ, Li ZY, Tang TY, Gaunt ME, Hayes PD, Gillard JH. Utility of high resolution MR imaging to assess carotid plaque morphology: a comparison of acute symptomatic, recently symptomatic and asymptomatic patients with carotid artery disease. Atherosclerosis. 2009 Dec;207(2):434-9.