Talmage Egan

Professor and Chair at Harvard Medical School

Schools

  • Harvard Medical School

Expertise

Links

Biography

Harvard Medical School

Languages Spoken: English, Japanese

Dr. Egan completed his undergraduate education at Brigham Young University, graduating Magna Cum Laude in the humanities. He attended medical school at the University of Utah School of Medicine where he was inducted into the Alpha Omega Alpha academic honor society. After completing a preliminary general surgery residency at the University of Utah, Dr. Egan sought postgraduate training in anesthesiology and critical care which he completed at Stanford University. Following residency he pursued fellowship training in clinical pharmacology also at Stanford. He recently completed intensive physician executive training at the Harvard School of Public Health.

Dr. Egan is currently staff physician and chair at the Department of Anesthesiology at the University of Utah Health Sciences Center. His clinical practice focuses on neurosurgery and obstetric patients. He is past President of the Medical Staff and Chairman of the Medical Board, and served for over a decade as the Chief of Neuroanesthesia.

Dr. Egan's research interests include the clinical pharmacology of sedatives and analgesics, the development of novel intravenous anesthetics and alternative propofol formulations, the development of optimal drug administration regimens based on pharmacokinetic-pharmacodynamic concepts, the identification of factors (i.e., gender, body weight, shock, SNPs, etc.) that influence drug behavior, and computer controlled drug delivery technology. These interests have resulted in successful entrepreneurial ventures, patents and trademarks. Dr. Egan is internationally regarded as a pioneer in the development of total intravenous anesthesia techniques, particularly the clinical application of the short acting opioid remifentanil, and the characterization of the interaction between propofol and opioids. His publications have been accompanied by numerous editorials and have been featured as cover stories in leading, peer-reviewed anesthesiology journals. Dr. Egan has mentored over 20 junior faculty and graduate students who have emerged as independent investigators.

Dr. Egan served for many years as a board member, treasurer, and president of the International Society for Anaesthetic Pharmacology. Currently an Associate Editor for the British Journal of Anaesthesia, he has also served as Associate Editor for Anesthesiology and guest reviewer for numerous other pharmacology, anesthesia and bioengineering journals. For many years Dr. Egan was a member and Chair of the American Society of Anesthesiology Subcommittee on Drug Disposition. He recently published a well-received anesthesia pharmacology and physiology textbook with Elsevier (Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application) as co-editor.

Dr. Egan was the inaugural recipient of the International Anesthesia Research Society’s Teaching Recognition Award. He is holder of the K.C. Wong Presidential Endowed Chair in Anesthesiology at the University of Utah. Dr. Egan has lectured extensively in the United States and internationally, including numerous honorary and keynote lectures at major universities and international anesthesiology societies.

His personal life is devoted to his wife of 30 years and their five children. He is fond of saying that his family is the most important element of his CV! Dr. Egan enjoys coaching basketball (two time Utah State AAU Boys Champions!), snow skiing, bass guitar, English literature and Japanese conversation.

BOARD CERTIFICATION AND ACADEMIC INFORMATION

  • Academic Departments Anesthesiology - Professor
  • Bioengineering - Adjunct Professor
  • Neurosurgery - Adjunct Professor
  • Pharmaceutics and Pharmaceutical Chemistry - Adjunct Professor
  • Academic Divisions Adult Neurosurgery
  • Board Certification American Board of Anesthesiology

EDUCATION HISTORY

  • Fellowship Stanford University School of Medicine Pharmacology Fellow
  • Residency Stanford University Medical Center Anesthesiology Resident
  • Residency University of Utah School of Medicine Anesthesiology Resident
  • Residency University of Utah School of Medicine Surgery Resident
  • Internship University of Utah School of Medicine Surgery Intern
  • Professional Medical University of Utah Medicine M.D.
  • Undergraduate Brigham Young University Humanities B.A.

SELECTED PUBLICATIONS - JOURNAL ARTICLES

Journal Article

  • Kim TK, Obara S, Egan TD, Minto CF, La Colla L, Drover DR, Vuyk J, Mertens M (01/01/2017). Disposition of Remifentanil in Obesity: A New Pharmacokinetic Model Incorporating the Influence of Body Mass. Anesthesiology, 126(6), 1019-1032.
  • Kim TK, Obara S, Egan TD, Minto CF, La Colla L, Drover DR, Vuyk J, Mertens M (2017). Disposition of Remifentanil in Obesity: A New Pharmacokinetic Model Incorporating the Influence of Body Mass. Anesthesiology, 126(6), 1019-1032.
  • Kuck K, Egan TD (2017). Getting the dose right: anaesthetic drug delivery and the posological sweet spot. Br J Anaesth, 119(5), 862-864.
  • Shafer SL, Egan T (2016). Target-Controlled Infusions: Surfing USA Redux. Anesth Analg, 122(1), 1-3.
  • Egan, TD (2015). Update on total intravenous anesthesia with special emphasis on cardiovascular anesthesia. J Cardiothorac Vasc Anesth, 29(Suppl 1), S1-2.
  • Egan, TD (2015). Total intravenous anesthesia versus inhalation anesthesia: a drug delivery perspective. J Cardiothorac Vasc Anesth, 29(Suppl 1), S3-6.
  • Sear JW, Egan TD (2015). David (Propofol Wannabes) Versus Goliath (Propofol): AZD-3043 Goes Up Against the Giant! Anesth Analg, 121(4), 849-51.
  • Soto R, Jahr JS, Pavlin J, Sabo D, Philip BK, Egan TD, Rowe E, de Bie J, Woo T (2015). Safety and Efficacy of Rocuronium With Sugammadex Reversal Versus Succinylcholine in Outpatient Surgery-A Multicenter, Randomized, Safety Assessor-Blinded Trial. (Epub ahead of print) Am J Ther.
  • Kim TK, Niklewski PJ, Martin JF, Obara S, Egan TD (2015). Enhancing a sedation score to include truly noxious stimulation: the Extended Observer's Assessment of Alertness and Sedation (EOAA/S). Br J Anaesth, 115(4), 569-77.
  • Yu L, Ting CK, Hill BE, Orr JA, Brewer LM, Johnson KB, Egan TD, Westenskow DR (2013). Using the entropy of tracheal sounds to detect apnea during sedation in healthy nonobese volunteers. Anesthesiology, 118(6), 1341-9.
  • Hanrahan SJ, Greger B, Parker RA, Ogura T, Obara S, Egan TD, House PA (2013). The effects of propofol on local field potential spectra, action potential firing rate, and their temporal relationship in humans and felines. Front Hum Neurosci, 7, 136.
  • Egan TD, Obara S, Jenkins TE, Jaw-Tsai SS, Amagasu S, Cook DR, Steffensen SC, Beattie DT (2012). AZD-3043: a novel, metabolically labile sedative-hypnotic agent with rapid and predictable emergence from hypnosis. Anesthesiology, 116(6), 1267-77.
  • LaPierre CD, Johnson KB, Randall BR, Egan TD (2012). A simulation study of common propofol and propofol-opioid dosing regimens for upper endoscopy: implications on the time course of recovery. Anesthesiology, 117(2), 252-62.
  • Syroid N, Liu D, Albert R, Agutter J, Egan TD, Pace NL, Johnson KB, Dowdle MR, Pulsipher D, Westenskow DR (2012). Graphical user interface simplifies infusion pump programming and enhances the ability to detect pump-related faults. Anesth Analg, 115(5), 1087-97.
  • Crystal B Wallentine, MD, Noriko Shimode, MD, Talmage D Egan, MD, and Nathan Pace, MD, MStat (October 2011). Propofol in a Modified Cyclodextrin Formulation: First Human Study of Dose-Response with Emphasis on Injection Pain. Anesth Analg, 113(4), 738-741.
  • LaPierre CD, Johnson KB, Randall BR, White JL, Egan TD (2011). An exploration of remifentanil-propofol combinations that lead to a loss of response to esophageal instrumentation, a loss of responsiveness, and/or onset of intolerable ventilatory depression. Anesth Analg, 113(3), 490-9.
  • Wallentine CB, Shimode N, Egan TD, Pace NL (2011). Propofol in a modified cyclodextrin formulation: first human study of dose-response with emphasis on injection pain. Anesth Analg, 113(4), 738-41.
  • Syroid ND, Johnson KB, Pace NL, Westenskow DR, Tyler D, Bruhschwein F, Albert RW, Roalstad S, Costy-Bennett S, Egan TD (2010). Response surface model predictions of emergence and response to pain in the recovery room: An evaluation of patients emerging from an isoflurane and fentanyl anesthetic. Anesth Analg, 111(2), 380-6.
  • Johnson KB, Syroid ND, Gupta DK, Manyam SC, Pace NL, LaPierre CD, Egan TD, White JL, Tyler D, Westenskow DR (2010). An evaluation of remifentanil-sevoflurane response surface models in patients emerging from anesthesia: model improvement using effect-site sevoflurane concentrations. Anesth Analg, 111(2), 387-94.
  • Sakata DJ, Matsubara I, Gopalakrishnan NA, Westenskow DR, White JL, Yamamori S, Egan TD, Pace NL (2009). Flow-through versus sidestream capnometry for detection of end tidal carbon dioxide in the sedated patient. J Clin Monit Comput, 23(2), 115-22.
  • Stanley TH, Egan TD, Van Aken H (2008). A tribute to Dr. Paul A. J. Janssen: entrepreneur extraordinaire, innovative scientist, and significant contributor to anesthesiology. Anesth Analg, 106(2), 451-62, table of contents.
  • Johnson KB, Syroid ND, Gupta DK, Manyam SC, Egan TD, Huntington J, White JL, Tyler D, Westenskow DR (2008). An evaluation of remifentanil propofol response surfaces for loss of responsiveness, loss of response to surrogates of painful stimuli and laryngoscopy in patients undergoing elective surgery. Anesth Analg, 106(2), 471-9, table of contents.
  • Manyam SC, Gupta DK, Johnson KB, White JL, Pace NL, Westenskow DR, Egan TD (2007). When is a bispectral index of 60 too low?: Rational processed electroencephalographic targets are dependent on the sedative-opioid ratio. Anesthesiology, 106(3), 472-83.
  • Nelson RY, Bretz B, Egan TD (2007). Prolonged apnea after remifentanil. Journal of Clinical Anesthesia, The, 19, 60-63.
  • Manyam SC, Gupta DK, Johnson KB, White JL, Pace NL, Westenskow DR, Egan TD (2006). Opioid-volatile anesthetic synergy: a response surface model with remifentanil and sevoflurane as prototypes. Anesthesiology, 105(2), 267-78.
  • Davis JJ, Swenson JD, Hall RH, Dillon JD, Johnson KB, Egan TD, Pace NL, Niu SY (2005). Preoperative "fentanyl challenge" as a tool to estimate postoperative opioid dosing in chronic opioid-consuming patients. Anesth Analg, 101(2), 389-95, table of contents.
  • Sikharam S, Egan TD, Kern SE (2005). Cyclodextrins as new formulation entities and therapeutic agents. Curr Opin Anaesthesiol, 18(4), 392-5.
  • Johnson KB, Egan TD, Kern SE, McJames SW, Cluff ML, Pace NL (2004). Influence of hemorrhagic shock followed by crystalloid resuscitation on propofol: a pharmacokinetic and pharmacodynamic analysis. Anesthesiology, 101(3), 647-59.
  • Kern SE, Xie G, White JL, Egan TD (2004). A response surface analysis of propofol-remifentanil pharmacodynamic interaction in volunteers. Anesthesiology, 100(6), 1373-81.
  • Egan TD, Kern SE, Muir KT, White J (2004). Remifentanil by bolus injection: a safety, pharmacokinetic, pharmacodynamic, and age effect investigation in human volunteers. Br J Anaesth, 92(3), 335-43.
  • Coull JT, Jones ME, Egan TD, Frith CD, Maze M (2004). Attentional effects of noradrenaline vary with arousal level: selective activation of thalamic pulvinar in humans. Neuroimage, 22(1), 315-22.
  • Johnson KB, Egan TD, Layman J, Kern SE, White JL, McJames SW (2003). The influence of hemorrhagic shock on etomidate: a pharmacokinetic and pharmacodynamic analysis. Anesth Analg, 96(5), 1360-8, table of contents.
  • Egan TD, Kern SE, Johnson KB, Pace NL (2003). The pharmacokinetics and pharmacodynamics of propofol in a modified cyclodextrin formulation (Captisol) versus propofol in a lipid formulation (Diprivan): an electroencephalographic and hemodynamic study in a porcine model. Anesth Analg, 97(1), 72-9, table of contents.
  • Johnson KB, Egan TD, Kern SE, White JL, McJames SW, Syroid N, Whiddon D, Church T (2003). The influence of hemorrhagic shock on propofol: a pharmacokinetic and pharmacodynamic analysis. Anesthesiology, 99(2), 409-20.
  • Lee M, Kern SE, Kisicki JC, Egan TD (2003). A pharmacokinetic study to compare two simultaneous 400 microg doses with a single 800 microg dose of oral transmucosal fentanyl citrate. J Pain Symptom Manage, 26(2), 743-7.
  • Davis PJ, Stiller RL, Wilson AS, McGowan FX, Egan TD, Muir KT (2002). In vitro remifentanil metabolism: the effects of whole blood constituents and plasma butyrylcholinesterase. Anesth Analg, 95(5), 1305-7, table of contents.
  • Johnson KB, Kern SE, Hamber EA, McJames SW, Kohnstamm KM, Egan TD (2001). Influence of hemorrhagic shock on remifentanil: a pharmacokinetic and pharmacodynamic analysis. Anesthesiology, 94(2), 322-32.
  • Egan TD, Muir KT, Hermann DJ, Stanski DR, Shafer SL (2001). The EEG and clinical measures of opioid potency: defining the EEG-clinical potency relationship ('fingerprint') with application to remifentanil. Int J Pharm Med, 15, 11-19.
  • Barr J, Egan TD, Sandoval NF, Zomorodi K, Cohane C, Gambus PL, Shafer SL (2001). Propofol dosing regimens for ICU sedation based upon an integrated pharmacokinetic-pharmacodynamic model. Anesthesiology, 95(2), 324-33.
  • Egan TD (2000). Pharmacokinetics and pharmacodynamics of remifentanil: an update in the year 2000. Curr Opin Anaesthesiol, 13(4), 449-55.
  • Egan TD, Sharma A, Ashburn MA, Kievit J, Pace NL, Streisand JB (2000). Multiple dose pharmacokinetics of oral transmucosal fentanyl citrate in healthy volunteers. Anesthesiology, 92(3), 665-73.
  • Miner JE, Egan TD (2000). An AIDS-associated cause of the difficult airway: supraglottic Kaposi's sarcoma. Anesth Analg, 90(5), 1223-6.
  • Manullang TR, Chun K, Egan TD (2000). The use of remifentanil for Cesarean section in a parturient with recurrent aortic coarctation. Can J Anaesth, 47(5), 454-9.
  • Farnsworth ST, Egan TD, Johnson SE, Westenskow D (2000). Teaching sedation and analgesia with simulation. J Clin Monit Comput, 16(4), 273-85.
  • Hermann DJ, Egan TD, Muir KT (1999). Influence of arteriovenous sampling on remifentanil pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther, 65(5), 511-8.
  • Reusche MD, Egan TD (1999). Remifentanil for conscious sedation and analgesia during awake fiberoptic tracheal intubation: a case report with pharmacokinetic simulations. J Clin Anesth, 11(1), 64-8.
  • Egan TD, Kuramkote S, Gong G, Zhang J, McJames SW, Bailey PL (1999). Fentanyl pharmacokinetics in hemorrhagic shock: a porcine model. Anesthesiology, 91(1), 156-66.
  • Manullang J, Egan TD (1999). Remifentanil's effect is not prolonged in a patient with pseudocholinesterase deficiency. Anesth Analg, 89(2), 529-30.
  • Brada SA, Egan TD, Viscomi CM (1998). The use of remifentanil infusion to facilitate epidural catheter placement in a parturient: a case report with pharmacokinetic simulations. Int J Obstet Anesth, 7(2), 124-7.
  • Johnson KB, Egan TD (1998). Remifentanil and propofol combination for awake craniotomy: case report with pharmacokinetic simulations. J Neurosurg Anesthesiol, 10(1), 25-9.
  • Streisand JB, Busch MA, Egan TD, Smith BG, Gay M, Pace NL (1998). Dose proportionality and pharmacokinetics of oral transmucosal fentanyl citrate. Anesthesiology, 88(2), 305-9.
  • Egan TD, Huizinga B, Gupta SK, Jaarsma RL, Sperry RJ, Yee JB, Muir KT (1998). Remifentanil pharmacokinetics in obese versus lean patients. Anesthesiology, 89(3), 562-73.
  • Smyth E, Egan TD (1998). Apneic oxygenation associated with patient-controlled analgesia. J Clin Anesth, 10(6), 499-501.
  • Egan TD (1998). The clinical pharmacology of remifentanil: a brief review. J Anesth, 12, 195-204.
  • Minto CF, Schnider TW, Egan TD, Youngs E, Lemmens HJ, Gambus PL, Billard V, Hoke JF, Moore KH, Hermann DJ, Muir KT, Mandema JW, Shafer SL (1997). Influence of age and gender on the pharmacokinetics and pharmacodynamics of remifentanil. I. Model development. Anesthesiology, 86(1), 10-23.
  • Egan TD (1997). Remifentanil: an esterase-metabolized opioid. West J Med, 166(3), 202.
  • Egan TD (1997). The clinical pharmacology of the new fentanyl congeners. Anesth Analg.
  • Egan TD, Minto CF, Hermann DJ, Barr J, Muir KT, Shafer SL (1996). Remifentanil versus alfentanil: comparative pharmacokinetics and pharmacodynamics in healthy adult male volunteers. Anesthesiology, 84(4), 821-33.

Review

  • Egan TD (2015). Total intravenous anesthesia versus inhalation anesthesia: a drug delivery perspective. [Review]. J Cardiothorac Vasc Anesth, 29 Suppl 1, S3-6.
  • Richardson SP, Egan TD (2005). The safety of remifentanil by bolus injection. [Review]. Expert Opin Drug Saf, 4(4), 643-51.
  • Egan TD (2003). Target-controlled drug delivery: progress toward an intravenous "vaporizer" and automated anesthetic administration. [Review]. Anesthesiology, 99(5), 1214-9.
  • Egan TD (1998). The clinical pharmacology of remifentanil: a brief review. [Review]. J Anesth, 12(4), 195-204.
  • Egan TD (1996). Intravenous drug delivery systems: toward an intravenous "vaporizer". [Review]. J Clin Anesth, 8(3 Suppl), 8S-14S.

Book

  • Hemmings HC, Egan TD (2013). Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application. Elselvier Inc.
  • Egan TD, Stanley TH (1999). Anesthesia for the New Millenium: Modern Anesthetic Clinical Pharmacology. Dordrecht, Holland: Kluwer Academic Publishers.

Book Chapter

  • Egan TD, Newberry C (01/01/2018). Opioids. In Miller RD, Pardo MC (Eds.), Basics of Anesthesia (7th). Philadelphia, PA: Elsevier.
  • Johnson KB, Egan TD (01/01/2015). Blood loss: Does it change my intravenous anesthetic? In Smith CE, Como J (Eds.), Trauma Anesthesia (2nd). New York, NY: Cambridge University Press.
  • Thackeray EM, Egan TD (01/01/2015). Analgesics. In Barash PG, Cullen BF, Stoelting RK, Cahalan MK, Stock MC, Ortega R, Sharar SR (Eds.), Clinical Anesthesia Fundamentals (1st). Philadelphia, PA: Wolters Kluwer Health.
  • Thackeray E, Egan, TD (2015). Analgesics. In Barash PG, Cullen BF, Stoelting RK, Cahalan MK, Stock MC, Ortega R, Sharar SR (Eds.), Clincal Anesthesia Fundamentals. New Haven: Wolters Kluwer Health Aids.
  • Ogura T, Egan TD (2013). Opioid Agonists and Antagonists. In Hemmings HC, Egan TD (Eds.), Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application (pp. 253-271). Elsevier.
  • Obara S, Egan TD (2013). Pharmacokinetic and Pharmacodynamic Principles for Intravenous Anesthetics. In Hemmings HC, Egan TD (Eds.), Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application. Elsevier Inc.
  • Johnson KB, Egan TD (2008). Principles of pharmacokinetics and pharmacodynamics: applied clinical pharmacology for the practitioner. In Longnecker DE, Brown DL, Newman MF, and Zapol WM (Eds.), Anesthesiology. New York, NY: McGraw Hill.
  • Johnson KB, Egan TD (2008). Blood loss: does it change my intravenous anesthetic? In Smith CE, Como J (Eds.), Trauma Anesthesia. New York, NY: Cambridge University Press.
  • Loose E, Egan TD (2006). Short Acting Intravenous Anesthetics. In Springman SR (Ed.), Ambulatory Anesthesia. Philadelphia, PA: Mosby/Elsevier.
  • Egan TD, Minto CF (2003). Pharmacodynamic drug interactions in anesthetic practice. In Evers AS, Maze M (Eds.), Anesthetic Pharmacology: Physiologic Principles and Clinical Practice. Philadelphia: Churchill Livingstone.
  • Egan TD (2001). The processed eletroencephalogram in clinical anesthesiology with special reference to the clinical application of the bisectral index. In Johnson JO, Stanley TH (Eds.), A Neuroanesthesia Odyssey. Salt Lake City, UT: University of Utah Press.
  • Egan TD (2001). Anesthetic considerations for awake craniotomy: a practical approach. In Johnson JO, Stanley TH (Eds.), A Neuroanesthesia Odyssey. Salt Lake City, UT: University of Utah Press.
  • Egan TD, Wong KC (2001). Cigarette Smoking Cessation and Anesthesia. In M Roizen, L Fleisher (Eds.), Essence of Anesthesia Practice (2nd Edition). Orlando, FL: WB Saunders Company.
  • Bailey PL, Egan TD, Stanley TH (1999). Opioids. In RD Miller (Ed.), Anesthesia (5th Edition). New York, NY: Churchill Livingstone.
  • Brody GA, Rinsky LA, Egan TD, Swenson JD (1999). Hand Surgery. In R Jaffe, S Samuels (Eds.), Anesthesiologist's Manual of Surgical Procedures (2nd Edition). New York, NY: Raven Press.
  • Ladd AL, Egan TD, Swenson JD (1999). Shoulder Surgery. In R Jaffe, S Samuels (Eds.), Anesthesiologist's Manual of Surgical Procedures (2nd Edition). New York, NY: Raven Press.
  • Egan TD (1999). Handedness in anesthetic pharmacology. In Egan TD, Stanley TH (Eds.), Anesthesia for the New Millennium- Modern Anesthetic Clinical Pharmacology. Dordrecht, The Netherlands: Kluwer Academic Publishers.
  • Egan TD (1999). Remifentanil: clinical applications. In Egan TD, Stanley TH (Eds.), Anesthesia for the New Millennium- Modern Anesthetic Clinical Pharmacology. Dordrecht, The Netherlands: Kluwer Academic Publishers.
  • Egan TD (1998). Modern clinical pharmacology concepts and pain management. In MA Ashburn, LJ Rice (Eds.), The Management of Pain (1st Edition). New York, NY: Churchill Livinstone.
  • Bailey PL, Egan TD (1997). Fentanyl and Congeners. In P White (Ed.), Intravenous Anesthesia and Analgesia (2nd Edition). Philadelphia, PA: Lea and Febiger.
  • Egan TD (1997). Intravenous Drug Delivery Devices and Computer Control. In P White (Ed.), Intravenous Anesthesia and Analgesia (2nd Edition). Philadelphia, PA: Lea and Febiger.
  • Egan TD, Wong KC (1996). Cigarette Smoking Cessation and Anesthesia. In M Roizen, L Fleisher (Eds.), Essence of Anesthesia Practice (1st Edition). Orlando, FL: WB Saunders Company.

Case Report

  • Nelson RY, Bretz B, Egan TD (2007). Prolonged apnea after remifentanil. J Clin Anesth, 19(1), 60-3.
  • Davis JJ, Johnson KB, Egan TD, Vezina DP, Snell TE, Swenson JD (2003). Preoperative fentanyl infusion with pharmacokinetic simulation for anesthetic and perioperative management of an opioid-tolerant patient. Anesth Analg, 97(6), 1661-2.
  • Johnson KB, Swenson JD, Egan TD, Jarrett R, Johnson M (2002). Midazolam and remifentanil by bolus injection for intensely stimulating procedures of brief duration: experience with awake laryngoscopy. Anesth Analg, 94(5), 1241-3, table of contents.
  • Honan DM, Breen PJ, Boylan JF, McDonald NJ, Egan TD (2002). Decrease in bispectral index preceding intraoperative hemodynamic crisis: evidence of acute alteration of propofol pharmacokinetics. Anesthesiology, 97(5), 1303-5.

Editorial

  • Short TG, Campbell D, Egan TD (01/01/2018). Increasing the utility of target-controlled infusions: one model to rule them all. B Jr Anesth, 120(5), 887-890.
  • Kuck K, Egan TD (01/01/2017). Getting the dose right: anaesthetic drug delivery and the posological sweet spot. Br J Anesth, 119(5), 862-864.
  • Shafer SL, Egan TD (01/01/2016). Target-controlled infusions: surfing USA redux. Anesth Analg, 122(1), 1-3.
  • Egan, TD (01/01/2015).
  • Update on total intravenous anesthesia with special emphasis on cardiovascular anesthesia
  • . J Cardiothorac Vasc Anesth, 29(Suppl 1), S1-2.
  • Egan TD (2015). Update on total intravenous anesthesia with special emphasis on cardiovascular anesthesia. J Cardiothorac Vasc Anesth, 29 Suppl 1, S1-2.
  • Sear JW, Egan TD (2015). David (Propofol Wannabes) Versus Goliath (Propofol): AZD-3043 Goes Up Against the Giant! Anesth Analg, 121(4), 849-51.
  • Egan TD (2010). Exploring the frontiers of propofol formulation strategy: is there life beyond the milky way? Br J Anaesth, 104(5), 533-5.
  • Egan TD (2009). Is anesthesiology going soft?: trends in fragile pharmacology. Anesthesiology, 111(2), 229-30.
  • Gupta DK, Manyam SC, Johnson KB, Egan TD (2007). Can 1% of sevoflurane with 5 ng/ml of remifentanil prevent implicit memory? Anesthesiology, 107, 1031.
  • Egan TD, Shafer SL (2003). Target-controlled infusions for intravenous anesthetics: surfing USA not! Anesthesiology, 99(5), 1039-41.
  • Egan TD (1996). Stereochemistry and anesthetic pharmacology: joining hands with the medicinal chemists. Anesth Analg, 83(3), 447-50.

Letter

  • Taikawa D, Soto E, Kurosaki D, Hiraoka H, Horiuchi R, Goto F, Johnson KB, Egan TD (2005). Pharmacodynamics of propofol during hemorrhagic shock [Letter to the editor]. Anesthesiology, 102(5), 1068-1070.
  • Egan TD, Kern SE (2004). Remifentanil is too potent to be given by bolus [Letter to the editor]. Br J Anaesth, 93(2), 305-306.
  • Egan TD (1998). New horizons in IV anesthesia. Society for Intravenous Anesthesia Newsletter [Letter to the editor]. Anesthesia and Analgesia, 3 (1), 2.
  • Bailey PL, Egan TD (1997). The successful implementation of pharmaceutical practice guidelines? Far from convincing! [Letter to the editor]. Anesthesiology, 87(6), 1583-4.
  • Abstract
  • Ermer S, Brewer L, Orr JA, Egan TD, Johnson KB (01/12/2018). Comparison of a Wide Respiratory Rate Range Reported from Seven Sensors in Non- Intubated, Spontaneously Breathing Volunteers [Abstract]. Society for Technology in Anesthesia Annual Meeting, Miami, FL, January 12, 2018.
  • Brewer L, Enos JS, Orr JA, Egan TD, Johnson KB (10/21/2017). A Computerized System to Prompt Healthy Volunteers to Breathe During Drug-Induced Respiratory Depression [Abstract]. American Society of Anesthesiologists Annual Meeting, Boston, MA, October 21, 2017.
  • Ermer S, Johnson KB, Orr JA, Hoehne S, White J, Egan TD, Brewer L (01/08/2016). Analysis of Central and Obstructive Apnea Detection Using Combination Sensors [Abstract]. Society for Technology in Anesthesia Annual Meeting, Palm Beach, FL, January 8, 2016.
  • Manyam SC, Chatwin DM, Decou JA, Johnson KB, White TD, Egan TD (2003). The auditory evoked potential and the bispectral index: A comparison study examining signal responses to inadequate anesthesia [Abstract]. Anesth Analg, 96, S132.
  • Egan TD, Shafer SL, Jenkins TE, Beattie DT, Jaw-Tsai SS (2003). The Pharmacokinetics and Pharmacodynamics of THRX-918661, a Novel Sedative/Hypnotic Agent [Abstract]. Anesthesiology, 99, A516.
  • Johnson KB, Egan TD, McJames SW, Cluff ML, Kern SE (2003). The Influence of Hemorrhagic Shock Followed by Crystalloid Resuscitation on Propofol: A Pharmacokinetic Analysis [Abstract]. Anesthesiology, 99, A652.
  • Sakaguchi FH, Syroid ND, White JB, Tyler DL, Egan TD (2003). Applying a Propofol-Remifentanil Response Surface Interaction Model in the Operating Room: An Observational Study [Abstract]. Anesthesiology, 99, A495.
  • Gupta DK, Manyam SC, Johnson KB, White JL, Egan TD (2003). The Auditory Evoked Potential and the Bispectral Index: A Comparison of Signal Performance During Clinically Inadequate Anesthesia [Abstract]. Anesthesiology, 99, A328.
  • Johnson KB, Peterson G, Egan TD, Kern SE, Pace NL (2002). Does propofol influence its own pharmacokinetics? A look at short duration high does propofol infusions in swine [Abstract]. Anesthesiology, 97, A681.
  • Egan TD, Kern SE, Johnson KB, Pace NL (2002). The pharmacokinetics and pharmacodynamics of propofol in a modified cyclodextrin formulation (Captisol) versus propofol in a lipid formulation (Diprivan): an electroencephalographic and hemodynamic study in a porcine model [Abstract]. Anesthesiology, 97, A437.
  • Mazer NA, Zobrist H, Stanworth SH, Egan TD (2002). Oral transmucosal administration of fentanyl acutely lowers LH and testosterone levels in healthy young men [Abstract]. Proceedings of the 84th Annual Meeting of the Endocrine Society, Poster #P2-666, San Francisco, CA.
  • Lertratanakul A, Kern SE, Egan TD (2001). EEG Approximate Entropy for Assessment of Subject Responsiveness to Laryngoscopy [Abstract]. Anesthesiology, 95, A292.
  • Johnson KB, Egan TD, Kern SE, Whiddon D, Lee J (2001). The influence of hemorrhagic shock on propofol: a pharmacokinetic analysis [Abstract]. Anesthesiology, 95, A649.
  • Egan TD, Kern SE, Johnson KB, Pace NL (2001). The Pharmacodynamics of propofol in a modified cyclodextrin formulation versus propofol in an intralipid formulation: an electroencephalographic and hemodynamic study in a porcine model [Abstract]. Anesthesiology, 95, A490.
  • Egan TD, Kern SE, Roland CL, Gay M (2001). The pharmacokinetics and safety of oral transmucosal fentanyl administered to healthy volunteers as two 400 mcg dosage units or as a single 800 mcg Actiq dosage unit [Abstract]. Proceedings of the 2001 Annual Meeting of the American Pain Society.
  • Jones M, Coull J, Egan T, Maze M (2001). Are subjects more easily aroused during sedation with the alpha-2 agonist dexmedetomidine? [Abstract]. Br J Anaesth, 86, 324P.
  • Egan TD, Kern SE, White JL, Cluff M (2000). Characterizing pharmacodynamic synergism between propofol and remifentanil in volunteers using response surfaces [Abstract]. Proceedings of the 2000 Annual Meeting of the Association of University Anesthetists.
  • Egan TD, Roland C, White JL, Gay MA, Kern SE (2000). A pilot study of oral transmucosal etomidate in volunteers [Abstract]. Anesthesiology, 93, A519.
  • Kern SE, Roland C, White JL, Gay MA, Egan TD (2000). PK/PD Analysis of etomidate given across the buccal mucosa [Abstract]. Anesthesiology, 93, A532.
  • Kern SE, Linares OJ, Egan TD (2000). Non-linear indicators of electroencephalographic changes that correlate with changing anesthetic concentrations [Abstract]. Anesthesiology, 93, A1372.
  • White JL, Kern SE, Egan TD (1999). Analgesia and respiratory effects of remifentanil boluses in elderly and adult volunteers [Abstract]. Anesthesiology, 91, A14.
  • Egan TD, Kern SE, White JL (1999). Prospective pharmacokinetic and pharmacodynamic validation on propofol's context sensitive T 1/2 [Abstract]. Anesthesiology, 91, A347.
  • Johnson KJ, Kern SE, Egan TD (1999). The effect of hypnotic-opioid interaction on target controlled infusion performance [Abstract]. Anesthesiology, 91, A343.
  • Kern SE, Egan TD, White JL, Cluff M (1999). Characterizing pharmacodynamic synergism between propofol and remifentanil in volunteers using response surfaces [Abstract]. Anesthesiology, 91, A342.
  • Kern SE, Dezaire DPJ, White JL, Egan TD (1999). Assessing the facial EMB as an indicator of response to noxious stimuli in anesthetized volunteers [Abstract]. Anesthesiology, 91, A594.
  • Johnson KB, Kern SE, Hamber EA, McJames S, Gong G, Kohnstamm K, Egan TD (1998). The influence of hemorrhagic shock on remifentanil: a pharmacokinetic analysis [Abstract]. Anesthesiology, A524.
  • Kern SE, Johnson KB, Hamber EA, McJames S, Gong G, Kohnstamm K, Egan TD (1998). The influence of hemorrhagic shock on remifentanil: a pharmacodynamic analysis [Abstract]. Anesthesiology, A523.
  • Egan TD, Kern SE, White JL, Wells DL, Johnson JO (1998). Assessing hypnotic and opioid interactions in volunteers using surrogate measures: a new study paradigm [Abstract]. Anesthesiology, A483.
  • Kuramkote S, Egan TD, McJames S, Gong G, Bailey PL (1997). Hemorrhagic shock alters fentanyl pharmacokinetics [Abstract]. Anesthesiology, 87, A374.
  • Lu J, Kern S, Schafer S, Bailey PL, Egan TD (1997). Prospective pharmacokinetic and pharmacodynamic validation of the context sensitive half-time for alfentanil [Abstract]. Anesthesiology, 87, A347.
  • Egan TD, Gupta SK, Sperry RJ, Yee JB, Huizinga B, Jaarsma RL, Muir KT (1996). The pharmacokinetics of remifentanil in obese versus lean elective surgery patients [Abstract]. Anesth Analg, 82, S100.
  • Egan TD, Muir KT, Stanski DR, Shafer SL (1996). Using the EEG fingerprint to define the clinical pharmacology of a new opioid: application to remifentanil [Abstract]. Clin Pharmacol Ther, 59, 129.
  • Egan TD, Muir KT, Stanski DR, Shafer SL (1996). The EEG versus clinical measures of opioid potency: defining the EEG-clinical potency fingerprint with application to remifentanil [Abstract]. Anesthesiology, 85, A349.

Video/Film/CD/Web/Podcast

  • Egan TD, Syroid N, Agutter J, Johnson KB (07/01/2018). Safe Sedation Training for Moderate Sedation (SSTmoderate) [Web]. Available: Medvis (www.safesedationtraining.com).
  • Egan TD, Syroid N, Agutter J, Johnson KB (10/01/2017). Safe Sedation Training for deep sedation (SSTdeep) [Web]. Available: Medvis (www.safesedationtraining.com).
  • Egan TD (2007). Moderate sedation for non-anesthesiologists: the scientific basis of safe clinical practices. Medscape (www.medscape.com), released December 26, 2007 [Web].
  • Egan, TD (2004). Advances in depth of anesthesia monitoring technology: Audio Digest 2004;46(23): side A [Video]. USA: Audio Digest.
  • Egan TD (2001). Clinical pharmacology of opioids and sedative-hypnotics. Part of an entire issue entitled "Anesthesia for the Elderly." Audio Digest 2001; 43 (17): Track 14 [Video].
  • KSL-TV Television Documentary (1998). Awake under the knife. Television documentary produced and broadcast by KSL-TV, a Salt Lake City, Utah based National Broadcasting Company affiliate, February 26th, 1998 [Video]. Salt Lake City: National Broadcasting Company.
  • Egan TD (1997). The clinical pharmacology of the new fentanyl congeners. IARS Annual Meeting Review Course Lectures CD-ROM. International Anesthesia Research Society, Cleveland, OH [CD].
  • Egan TD (1997). The New Fentanyl Congeners. Audio Digest 1997; 39(11): side A [Video].
  • Patent
  • Egan, TD (07/15/2015). Safe Sedation Training SST (4568924), Applied Medical Visualizations, July 15th, 2015.
  • Egan, TD (11/21/2017). SST Safe Sedation Training(5338215), Applied Medical Visualizations, November 21st, 2017.
  • Egan, TD (08/19/2015). SST Sim (4590101), Applied Medical Visualizations, August 19th, 2015.

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