Roshni Singaraja

ACADEMIC QUALIFICATIONS

• PhD, University of Amsterdam, The Netherlands
• BSc (Hons), University of Waterloo, Canada

RESEARCH AREAS

• Cardiovascular Diseases : Cellular and Molecular Mechanisms, Genetics
• Metabolic Diseases and Diabetes : Cellular and Molecular Mechanisms, Genetics and Nutrition

RESEARCH INTEREST(S)

• Diabetes
• Cardiovascular Disease
• Lipid Metabolism
• Bile Acids
• Human Genetics
• Target Identification and Validation

RECENT PUBLICATIONS

• Paththinige, C. S., Rajapakse, J. R. D. K., Constantine, G. R., Sem, K. P., Singaraja, R. R., Jayasekara, R. W., & Dissanayake, V. H. W. (2018). Spectrum of low-density lipoprotein receptor (LDLR) mutations in a cohort of Sri Lankan patients with familial hypercholesterolemia – A preliminary report. Lipids in Health and Disease, 17(1). doi:10.1186/s12944-018-0763-z
• Chevre, R., Trigueros-Motos, L., Castano, D., Chua, T., Corliano, M., Patankar, J. V., . . . Singaraja, R. R. (2018). Therapeutic modulation of the bile acid pool by Cyp8b1 knockdown protects against nonalcoholic fatty liver disease in mice. FASEB JOURNAL, 32(7), 3792-3802. doi:10.1096/fj.201701084RR
• Trigueros-Motos, L., Van Capelleveen, J. C., Torta, F., Castao, D., Zhang, L. H., Chai, E. C., . . . Singaraja, R. R. (2017). ABCA8 regulates cholesterol efflux and high-density lipoprotein cholesterol levels. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(11), 2147-2155. doi:10.1161/ATVBAHA.117.309574
• Skotte, N. H., Sanders, S. S., Singaraja, R. R., Ehrnhoefer, D. E., Vaid, K., Qiu, X., . . . Hayden, M. R. (2017). Palmitoylation of caspase-6 by HIP14 regulates its activation. Cell Death and Differentiation, 24(3), 433-444. doi:10.1038/cdd.2016.139
• Sadananda, S. N., Foo, J. N., Toh, M. T., Cermakova, L., Trigueros-Motos, L., Chan, T., . . . Brunham, L. R. (2015). Targeted next-generation sequencing to diagnose disorders of HDL cholesterol. JOURNAL OF LIPID RESEARCH, 56(10), 1993-2001. doi:10.1194/jlr.P058891