Reshma Taneja

Education

• Indian Institute of Science (IISc)

Companies

• Head, Department of Physiology National University of Singapore (2020)
• Professor, Department of Physiology National University of Singapore (2020)
• Acting Head, Department of Physiology National University of Singapore (2019 — 2020)
• Deputy Head, Department of Physiology National University of Singapore (2018 — 2019)
• Associate Professor National University of Singapore (2008 — 2016)
• Associate Professor Icahn School of Medicine at Mount Sinai (2003 — 2008)
• Assistant Professor Icahn School of Medicine at Mount Sinai (1997 — 2002)
• Postdoctoral Fellow IGBMC (1992 — 1997)

Research Areas of Interest

• Epigenetic regulation of skeletal muscle differentiation and regeneration
• Chromatin signalling networks in myopathies

Selected Publications

• Pal A, Leung JY, Ang GCK, Rao VK, Pignata L, Lim HJ, Hebrard M, Chang KT, Lee VKM, Guccione E, and Taneja R (2020). Deregulation of the histone H3K9 di-methylation landscape suppresses canonical Wnt signaling in embryonal rhabdomyosarcoma. eLife 2020;9:e57683.
• Bhat AV, Palanichamy Kala M, Rao VK, Pignata L, Lim HJ, Suriyamurthy S, Chang KTE, Lee VK, Guccione E, Taneja R. Epigenetic regulation of the PTEN-AKT-RAC1 axis by G9a is critical for tumor growth in alveolar rhabdomyosarcoma. Cancer Research 2019 79:2232-2243
• Numata A, Kwok HS, Kawasaki A, Li J, Zhou QL, Kerry J, Benoukraf T, Bararia D, Li F, Ballabio E, Tapia M, Deshpande AJ, Welner RS, Delwel R, Yang H, Milne TA, Taneja R*, Tenen DG*. The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia. Nat Commun. 2018 9:1622. *co-corresponding authors
• Bharathy N. Suriyamurthy S, Rao Vk, Lim Hj, Chakraborty P, Vasudevan M, Dhamne A, Chang K, Lee V, Kundu T, Taneja R. (2016) P/CAF mediates PAX3-FOXO1 dependent oncogenesis in alveolar rhabdomyosarcoma. J Pathology 240: 269-281.
• Rao VK, Ow JR, Shankar S, Bharathy N, Manikadan J and Taneja R. (2016) G9a promotes proliferation and inhibits cell cycle exit during myogenic differentiation. Nucleic Acids Research 44: 8129-8143.
• Ling B, Bharathy N, Chung T-K, Kok WK, Li SD, Tan YH, Rao VK, Gopinadhan S, Sartorelli V, Walsh MJ, and Taneja R. Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation. Proc. Natl. Acad. Sci. (USA) 2012. 109:841-846.
• Vercherat C, Chung T-K, Yalcin S, Gulbagci N, Gopinadhan S, Ghaffari S and Taneja R. Stra13 regulates oxidative stress mediated skeletal muscle degeneration. Human Molecular Genetics 2009. 18:4304-4316 (featured on journal cover).
• Sun H, Li L, Vercherat C, Gulbagci N, Acharjee S, Li J, Chung T-K, Thin T, and Taneja R. Stra13 regulates satellite cell activation by antagonizing Notch signaling. J. Cell Biol. 2007 177:647-57.
• Sun H, Lu B, Li R-Q, Flavell RA, and Taneja, R.Defective T-cell activation and autoimmune disorder in Stra13-deficient mice. Nature Immunology 2001. 2:1040-1047.
• Sun H and Taneja R.tra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC) dependent and HDAC independent mechanisms. Proc. Natl. Acad. Sci (USA) 2000 97:4058-4063.