Melissa Putman

Dr. Putman is board certified in internal medicine, pediatrics, adult endocrinology and pediatric endocrinology. She sees patients and participates in clinical research in the Divisions of Endocrinology at Boston Children’s Hospital and Massachusetts General Hospital. Her primary research goal is improving the care of children and young adults with chronic diseases to prevent the endocrine complications that may significantly affect their future adult lives. She has developed several research studies focused on improving our understanding and management of cystic fibrosis (CF) related endocrine disorders, including CF related diabetes and CF related bone disease. She is also collaborating with physicians in Orthopaedic Surgery and General Surgery at Boston Children’s Hospital along with engineers at the Wyss Institute for Biologically Inspired Engineering on technology aimed at improving skeletal health in hospitalized infants and children.

Departments, Centers, & Programs:

• Endocrinology

Research Interests

absorptiometry photon; bone and bones; cystic fibrosis; fibrous dysplasia of bone; forearm; skeletal health; vitamin d; vitamin d deficiency

Medical Education

• MD, University of North Carolina School of Medicine Administration
• MD, University of North Carolina, School of Medicine
• Residency, Massachusetts General Hospital
• Fellowship, Children's Hospital Boston
• Fellowship, Massachusetts General Hospital

American Board Certifications

• Endocrinology, Diabetes & Metabolism, American Board of Internal Medicine
• Endocrinology, Diabetes and Metabolism, American Board of Internal Medicine
• Pediatric Endocrinology, American Board of Pediatrics
• Pediatrics, American Board of Pediatrics

PUBLICATIONS

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• Gestational and pregestational diabetes in pregnant women with cystic fibrosis. J Clin Transl Endocrinol. 2022 Mar; 27:100289.
• Practical aspects of diabetes technology use: Continuous glucose monitors, insulin pumps, and automated insulin delivery systems. J Clin Transl Endocrinol. 2022 Mar; 27:100282.
• Continuous Glucose Monitoring and HbA1c in Cystic Fibrosis: Clinical Correlations and Implications for CFRD Diagnosis. J Clin Endocrinol Metab. 2021 Nov 29.
• Age-Related Changes in Bone Density, Microarchitecture, and Strength in Postmenopausal Black and White Women: The SWAN Longitudinal HR-pQCT Study. J Bone Miner Res. 2021 Oct 14.
• The effect of elexacaftor/tezacaftor/ivacaftor (ETI) on glycemia in adults with cystic fibrosis. J Cyst Fibros. 2021 Sep 13.
• Recombinant growth hormone therapy for cystic fibrosis in children and young adults. Cochrane Database Syst Rev. 2021 08 23; 8:CD008901.
• Perceptions of Diabetes Technology Use in Cystic Fibrosis-Related Diabetes Management. Diabetes Technol Ther. 2021 Nov; 23(11):753-759.
• The Effects of Ivacaftor on Bone Density and Microarchitecture in Children and Adults with Cystic Fibrosis. J Clin Endocrinol Metab. 2021 03 08; 106(3):e1248-e1261.
• Monogenic Diabetes in a Child with Cystic Fibrosis: A Case Report and Review of the Literature. J Endocr Soc. 2021 Jan 01; 5(1):bvaa165.
• New and Emerging Technologies in Type 1 Diabetes. Endocrinol Metab Clin North Am. 2020 12; 49(4):667-678.
• Diabetes as a Risk Factor for Poor Early Outcomes in Patients Hospitalized With COVID-19. Diabetes Care. 2020 12; 43(12):2938-2944.
• Oral ethinyl estradiol treatment in women with cystic fibrosis is associated with lower bone mineral density. J Clin Transl Endocrinol. 2020 Jun; 20:100223.
• Endocrine Complications of Cystic Fibrosis: A Multisystem Disease of the Endocrine Organs. Semin Respir Crit Care Med. 2019 12; 40(6):810-824.
• Cystic fibrosis bone disease: Pathophysiology, assessment and prognostic implications. J Cyst Fibros. 2019 10; 18 Suppl 2:S48-S55.
• Growth failure and treatment in cystic fibrosis. J Cyst Fibros. 2019 10; 18 Suppl 2:S82-S87.
• Cystic fibrosis bone disease treatment: Current knowledge and future directions. J Cyst Fibros. 2019 10; 18 Suppl 2:S56-S65.
• Automated glycemic control with the bionic pancreas in cystic fibrosis-related diabetes: A pilot study. J Cyst Fibros. 2020 01; 19(1):159-161.
• Bone Health Screening Practices Among Neurologists in Patients on Antiepileptic Drugs: A Quality Improvement Project. Pediatr Neurol. 2020 01; 102:49-55.
• Recombinant growth hormone therapy for cystic fibrosis in children and young adults. Cochrane Database Syst Rev. 2018 12 17; 12:CD008901.
• Low bone density and fractures before and after pediatric lung transplantation. Bone. 2018 06; 111:129-134.
• Celiac Disease in Patients with Cystic Fibrosis-Related Bone Disease. Case Rep Endocrinol. 2017; 2017:2652403.
• Differences in Trabecular Microstructure Between Black and White Women Assessed by Individual Trabecular Segmentation Analysis of HR-pQCT Images. J Bone Miner Res. 2017 May; 32(5):1100-1108.
• A pediatric animal model to evaluate the effects of disuse on musculoskeletal growth and development. J Biomech. 2016 10 03; 49(14):3549-3554.
• Young adults with cystic fibrosis have altered trabecular microstructure by ITS-based morphological analysis. Osteoporos Int. 2016 08; 27(8):2497-505.
• Body composition, lung function, and prevalent and progressive bone deficits among adults with cystic fibrosis. Joint Bone Spine. 2016 Mar; 83(2):207-11.
• High incidence of fracture events in patients with Long-Gap Esophageal Atresia (LGEA): A retrospective review prompting implementation of standardized protocol. Bone Rep. 2015 Dec; 3:1-4.
• Trends in bone mineral density in young adults with cystic fibrosis over a 15 year period. J Cyst Fibros. 2015 Jul; 14(4):526-32.
• Two-year changes in bone density after Roux-en-Y gastric bypass surgery. J Clin Endocrinol Metab. 2015 Apr; 100(4):1452-9.
• Response letter to the editor. J Clin Endocrinol Metab. 2015 Jan; 100(1):L9-L10.
• Defects in cortical microarchitecture among African-American women with type 2 diabetes. Osteoporos Int. 2015 Feb; 26(2):673-9.
• Compromised bone microarchitecture and estimated bone strength in young adults with cystic fibrosis. J Clin Endocrinol Metab. 2014 Sep; 99(9):3399-407.
• Differences in skeletal microarchitecture and strength in African-American and white women. J Bone Miner Res. 2013 Oct; 28(10):2177-85.
• 50 years ago in the Journal of Pediatrics: Neonatal fibrous dysplasia. Turner AF, Mikity VG, Meyers HI. J Pediatr 1963;62:936-7. J Pediatr. 2013 Jun; 162(6):1119.
• Measures of the forearm via a portable device: ready for prime time? J Clin Densitom. 2013 Jan-Mar; 16(1):125-6.
• A randomized clinical trial of vitamin D supplementation in healthy adolescents. J Adolesc Health. 2013 May; 52(5):592-8.
• Cortical microstructure and estimated bone strength in young amenorrheic athletes, eumenorrheic athletes and non-athletes. Bone. 2012 Oct; 51(4):680-7.
• Contribution of villous atrophy to reduced intestinal maltase in infants with malnutrition. J Pediatr Gastroenterol Nutr. 2000 May; 30(5):494-502.
• Deficient 17beta-hydroxysteroid dehydrogenase type 2 expression in endometriosis: failure to metabolize 17beta-estradiol. J Clin Endocrinol Metab. 1998 Dec; 83(12):4474-80.
• Effects of malnutrition on expression and activity of lactase in children. Gastroenterology. 1997 Mar; 112(3):742-51.
• Developmental changes in lactase-phlorizin hydrolase precursor isoforms in the rat. J Pediatr Gastroenterol Nutr. 1992 Oct; 15(3):260-9.
• Mosaic expression of brush-border enzymes in infants with chronic diarrhea and malnutrition. J Pediatr Gastroenterol Nutr. 1992 May; 14(4):371-9.