Mathias Lichterfeld

Dr. Lichterfeld is an infectious disease physician at BWH and an Associate Professor at HMS. He is also an Associate Member of the Ragon Institute and of the Broad Institute of MIT and Harvard. He received his medical degree from the University of Heidelberg, Germany and completed his residency at Massachusetts General Hospital. In 2008-2011, he was an infectious disease fellow at the Brigham and Women’s Hospital and at Massachusetts General Hospital, with Dr. Eric Rosenberg as his mentor. He is a member of the American Association for Clinical Investigation, a fellow of the Infectious Disease Society of America, and has served as a chartered member of several study sections at the National Institutes of Health.

Dr. Lichterfeld’s research interests focus on retroviral infections, specifically on HIV-1. His laboratory explores how HIV-1 can persist in the human body for a lifetime, despite very effective antiretroviral therapy that is available now; these studies involve a platform of recently-developed new technologies for single-cell profiling of virally-infected cells. Dr. Lichterfeld also leads clinical trials in which novel therapeutic approaches for HIV eradication and cure are evaluated; several of these studies are currently enrolling new patients. In collaboration with investigators from the Harvard School of Public Health, Dr. Lichterfeld’s lab also participates as a co-investigator in clinical trials with HIV-1-infected infants from Botswana.

Education

• Harvard Medical School - Massachusetts General Hospital
  Clinical and Research Fellow, Infectious Diseases

• Harvard Medical School - Massachusetts General Hospital
  Intern and Resident, Internal Medicine Residency Program

• Harvard Medical School - Massachusetts General Hospital
  Research Fellow, Immunology

• University of Bonn Medical Center
  Intern, Internal Medicine Residency Program

• Heidelberg University
  M. D., Ph. D., Medicine

Selected Publications

• Clonal expansion of genome-intact HIV-1 in functionally-polarized Th1 CD4 T cells
  Lee GQ, Orlova-Fink N, Einkauf K, Chowdhury FZ, Sun X, Harrington S, Kuo HH, Hua S, Chen HR, Ouyang Z, Reddy K, Dong K, Ndung’u T, Walker BD, Rosenberg ES, Yu XG, Lichterfeld M. J Clin Invest 2017, 127:2689-2696

• Preferential susceptibility of Th9 and Th2 CD4 T cells to X4-tropic HIV-1 infection
  Orlova-Fink N, Chowdhury FZ, Sun X, Harrington S, Rosenberg ES, Yu XG, Lichterfeld M. AIDS 2017 Oct 23;31(16):2211-2215

• Anti-apoptotic protein BIRC5 maintains survival of HIV-1 infected CD4 T cells
  Kuo HH, Ahmad R, Lee GQ, Chen HR, Ouyang Z, Szucs MJ, Kim D, Tsibris A, Chun TW, Battivelli E, Verdin E, Rosenberg ES, Carr S, Yu XG, Lichterfeld M.Immunity 2018, 48:1183-1194

• Accumulation of intact HIV-1 proviruses with distinct chromosomal positions during long-term antiretroviral therapy
  Einkauf K, Lee GQ, Gao C, Sharaf R, Sun X, Hua s, Chen S, Jiang C, Lian X, Chowdhury FZ, Rosenberg ES, Chun TW, Li JZ, Yu XG, Lichterfeld M. J Clin Invest 2019, 129:988-998

• Early antiretroviral therapy in neonates with HIV-1 infection restricts viral reservoir size and induces a distinct innate immune profile
  Garcia-Broncano P, Maddali S, Einkauf KB, Jiang C, Gao C, Chevalier J, Chowdhury FZ, Maswabi K, Ajibola G, Moyo S, Mohammed T, Ncube T, Makhema J, Jean-Philippe P, Yu XG, Powis KM, Lockman S, Kuritzkes DR, Shapiro R, Lichterfeld M. Sci Transl Med. 2019 Nov 27;11(520):eaax7350

• HIV-1 DNA sequence diversity and evolution during acute subtype C infection
  Lee GQ, Reddy K, Einkauf KB, Gounder K, Chevalier JM, Dong KL, Walker BD, Yu XG, Ndung'u T, Lichterfeld M. Nat Commun. 2019 Jun 21;10(1):2737.

• Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy
  Einkauf KB, Lee GQ, Gao C, Sharaf R, Sun X, Hua S, Chen SM, Jiang C, Lian X, Chowdhury FZ, Rosenberg ES, Chun TW, Li JZ, Yu XG, Lichterfeld M. Clin Invest. 2019 Mar 1;129(3):988-998.

• Blood and Lymph Node Dissemination of Clonal Genome-Intact Human Immunodeficiency Virus 1 DNA Sequences During Suppressive Antiretroviral Therapy
  Kuo HH, Banga R, Lee GQ, Gao C, Cavassini M, Corpataux JM, Blackmer JE, Zur Wiesch S, Yu XG, Pantaleo G, Perreau M, Lichterfeld M. J Infect Dis. 2020 Jul 23;222(4):655-660.