Jianbo Yue
Associate Professor, Department of Biomedical Sciences at City University of Hong Kong
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Biography
Education
- PhD Penn State University (1995 — 2000)
- Master's degree Peking University (1991 — 1994)
- Bachelor's degree Sichuan University (1987 — 1991)
Research interests:
Cell signaling and drug discovery related to autophagy, endosomal trafficking, mitotic kinases/ATPase, and Ca2+, in the context of metastasis, anticancer immunity, and virus infection
Currently, several research themes are going on in my laboratory:
- Endosomal trafficking in metastasis and anticancer immune response;
- the interplay between mitotic kinases and ATPases;
- Ca2+ signaling in virus infection; and
- regulation of autophagy and cell death by Ca+ signaling and ROS.
Representive Publications
- Wang D, Ye Z, Wei W, Yu J, Huang L, Zhang H, Yue J* (2021) Capping protein regulates endocytosis by controlling F-actin density and recruiting RAB5 effectors to early endosomes. eLife (In press).
- Xie F, Xu S, Lu Y, Manno S, Won KF, Sun L, Yue J*, Cheng SH* (2021) Metformin accelerates zebrafish heart regeneration by inducing autophagy. npj Regenerative Medicine 6: 62.
- Huang L, Li H, Ye Z, Xu Q, Fu Q, Sun W, Qi W*, Yue J* (2021) Berbamine inhibits Japanese Encephalitis virus (JEV) infection by compromising TPRMLs-mediated endolysosomal trafficking of Low-density lipoprotein receptor (LDLR). Emerging Microbes & Infections 10, 1257-1271.
- Huang L, Yuen T, Ye Z, Liu S, Zhang G, Chu H*, Yue J* (2021) Berbamine inhibits SARS-CoV-2 infection by compromising TPRMLs-mediated endolysosomal trafficking of ACE2. Signal Transduct Target Ther. 6: 168.
- Ye Z, Wang D, He Y, Yu J, Wei W, Chen C, Wang R, Zhang L, Zhang LH, Zhang LR, Le M, Cho W, M Yang, Zhang H, Yue J* (2021) Vacuolin-1 inhibits endosomal trafficking and metastasis via CapZβ. Oncogene 40, 1775-1791.
- Guo W, Wang Q, Pan S, Li J, Shu Y, Chen J, Wang Q, Zhang S, Zhang X, Yue J* (2021) The ERK1/2-ATG13-FIP200 signaling cascade is required for autophagy induction to protect renal cells from hypoglycemia-induced cell death. J. Cell. Physiol. 236: 6932-6947.
- Shi X, Zhu K, Ye Z, Yue J* (2020) VCP/p97 targets the nuclear export and degradation of p27Kip1 during G1 to S phase transition. FASEB J. 34(4):5193-5207.
- Li C, Huang L, Sun W, Chen Y, He M*, Yue J*, Ballard H* (2019) Saikosaponin D potently Inhibits Autophagy to Suppress EV71 infection. Signal Transduct Target Ther. 4:4.
- Zhang K, Sun W, Huang L, Zhu K, Zhu L, Wang Q, Lu Y, Zhang HM, Jin H, Zhang LH*, Zhang LR*, Yue J* (2017) Identifying GAPDH as a Novel Cyclic Adenosine Diphosphoribose (cADPR) Binding Protein by Photoaffinity Protein-Ligand Labeling Approach. J Am Chem. Soc. 139:156-170.
- Wang Q, Guo W, Hao B, Shi X, Wong C, Hao Q, Cheung HK, Wu WT, Li GR, Lu Y, Yue J* (2016) Mechanistic Study of the Role of TRPM2-Ca2+ Signaling in Oxidative Stress Induced Autophagy Inhibition. Autophagy 12: 1340-1354.
- Wei W, Lu Y, Hai B, Zhang K, Wang Q, Miller AL, Zhang LR, Zhang LH, Yue J* (2015) CD38 is Required for Neural Differentiation of Mouse Embryonic Stem Cells by Modulating Reactive Oxygen Species (ROS). Stem Cells 33, 2664-2673.
- Lu Y, Dong S, Hao B, Wang Q, Guo W,Cheung KH, Wong C, Wu WT, Markus H, Yue J* (2014) Vacuolin-1 Potently and Reversibly Inhibits Autophagy by Activating Rab5. Autophagy 10, 1895-1905.
- Wei W, Sun H, Ting K, Zhang LH, Lee HC, Li G, Yue J* (2012) Inhibition of Cardiomyocyte Differentiation of Mouse Embryonic Stem Cells by CD38/cADPR/Ca2+ Signaling Pathway. J. Biol. Chem. 287, 35599–35611.
- Yu P, Zhang Z, Hao B, Zhao Y, Lee HC, Zhang LH, Zhang LR, Yue J* (2012) A Novel Fluorescent Cell Membrane Permeable Caged-cADPR Analogue. J. Biol. Chem. 287, 24774-24783.
- Yue J*, Wei W, Lam CM, Zhao YJ, Dong M, Zhang LR, Zhang LH, Lee HC*. (2009) CD38/cADPR/ Ca2+-Pathway Promotes Cell Proliferation and Delays NGF-Induced Differentiation in PC12 Cells. J. Biol. Chem. 284, 29335-29342.
- Yue J*, Ferrell JE Jr. (2006) Mechanistic Studies of the Mitotic Activation of Mos. Mol Cell Biol. 26, 5300-5309.
- Yue J*, Xiong W, Ferrell JE Jr. (2006) B-Raf and C-Raf are required for Ras-stimulated p42 MAP kinase activation in Xenopus egg extracts. Oncogene, 25, 3307-3315..
- Yue J*, Ferrell JE Jr. (2004) Mos Mediates the Mitotic Activation of p42 MAPK in Xenopus Egg Extracts. Curr. Biol. 14, 1581-1586.
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