Erwin Böttinger

The research group Digital Health of Prof. Dr. med. Erwin Böttinger addresses the challenges and opportunities of digital transformation for the healthcare system.

The research focus lies on personalized medicine, which uses genomics and bioinformatics approaches to identify molecular disease mechanisms with the aim of improving prevention, diagnosis and therapy while leading to more efficient healthcare.

Appointments/Employment

1986-1987: Intern, Nuremberg General Hospital, University of Erlangen-Nuremberg, Germany

1995-1997: Visiting Associate, National Cancer Institute, National Institutes of Health, Bethesda, MD;

1997-2001: Assistant Professor of Medicine, Albert Einstein College of Medicine, Bronx, NY

1998-2001: Assistant Professor of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY

2001-2004: Associate Professor of Medicine, Albert Einstein College of Medicine, Bronx, NY

2001-2004: Associate Professor of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY

2004-2015: Professor of Medicine (with tenure), Icahn School of Medicine at Mount Sinai, New York, NY

2004-2015: Professor of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY

2015-2017: W3 Professor fuer Personalisierte Medizin, Charite University Medicine, Berlin, Germany

2015-2017: Chief Executive Officer, Berlin Institute of Health, Berlin, Germany

2017- : W3 Professor for Digital Health Personalized Medicine, Hasso Plattner Institute and University of Potsdam, Berlin-Potsdam, Germany

2017- : Head, Digital Health Center, Hasso Plattner Institute, Potsdam, Germany

Education

1972-1979: Abitur, Graf-Stauffenberg Gymnasium, Bamberg, Germany

1979-1986: M.D., Friedrich-Alexander Universitat, School of Medicine, ErIangen-Nuremberg, Germany

1987-1990: Resident, Internal Medicine, Cabrini Medical Center, New York

1990-1993: Clinical and Research Fellow in Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA

1993-1995: Research Fellow, National Cancer Institute, National Institutes of Health, Bethesda, MD

Certification

1986: Approbation als Arzt, Germany

1986: Doktor der Medizin (Dr. med.; M.D.), Germany

1987: Foreign Medical Graduate Examination in Medical Sciences (ECFMG), U.S.A.

1989: Federal Licensing Examination (FLEX), U.S.A.

1990: American Board of Internal Medicine, Diplomate, U.S.A.

1993: American Board of Internal Medicine, Diplomate, Subspecialty: Nephrology, U.S.A.

Honors/Awards

1979-86: Scholar of the Bavarian State Foundation for the most gifted student (top graduating students in Bavaria); Full scholarship for medical school, Germany 1991: National Kidney Foundation, Fellowship Award, U.S.A. 1993: Fogarty International Center, Visiting Fellowship Award, U.S.A. 1997: National Cancer Institute, Special Service Award, U.S.A. 1998: National Kidney Foundation Young Investigator Award, New York/New Jersey Affiliate, U.S.A. 2002: Mellini Award for Excellence in Biomedical Sciences, U.S.A. 2004 - The Irene and Dr. Arthur Fishberg Endowed Chair in Medicine

Research profile

• Cell and molecular biology (since 1991)
• Constitutive and conditional gene deletion and transgenic animal models (since 1993)
• Genomics and genetics, systems biology, bioinformatics (since 1999)
• Clinical trials (2005 to 2008)
• Clinical information systems, electronic medical records (since 2007)
• Translational research and implementation science (since 2009)
• Research administration and leadership (since 2001)

Publications

Most relevant papers

• Levin MA, Joseph TT, Jeff JM, Nadukuru R, Ellis SB, Bottinger EP, Kenny EE.
• iGAS: A framework for using electronic intraoperative medical records for genomic discovery. J Biomed Inform. 2017 Mar;67:80-89. PubMed PMID: 28193464.
• Singh A, Nadkarni G, Gottesman O, Ellis SB, Bottinger EP, Guttag JV.
• Incorporating temporal EHR data in predictive models for risk stratification of renal function deterioration. J Biomed Inform. 2015 Feb;53:220-8. Epub 2014 Nov 15. PubMed PMID: 25460205; PubMed Central PMCID: PMC4520404.
• Huopaniemi I, Nadkarni G, Nadukuru R, Lotay V, Ellis S, Gottesman O, Bottinger EP.
• Disease progression subtype discovery from longitudinal EMR data with a majority of missing values and unknown initial time points. AMIA Annu Symp Proc. 2014 Nov 14;2014:709-18. eCollection 2014. PubMed PMID: 25954377; PubMed Central PMCID: PMC4419979.
• Nadkarni GN, Gottesman O, Linneman JG, Chase H, Berg RL, Farouk S, Nadukuru R, Lotay V, Ellis S, Hripcsak G, Peissig P, Weng C, Bottinger EP.
• Development and validation of an electronic phenotyping algorithm for chronic kidney disease.
• AMIA Annu Symp Proc. 2014 Nov 14;2014:907-16. eCollection 2014. PubMed PMID: 25954398; PubMed Central PMCID: PMC4419875.
• Gottesman O, Scott SA, Ellis SB, Overby CL, Ludtke A, Hulot JS, Hall J, Chatani K, Myers K, Kannry JL, Bottinger EP.
• The CLIPMERGE PGx Program: clinical implementation of personalized medicine through electronic health records and genomics-pharmacogenomics.
• Clin Pharmacol Ther. 2013 Aug;94(2):214-7. PubMed PMID: 23588317; PubMed Central PMCID: PMC3720762.