Eric Norstrom

Research Interests

The efforts of Norstrom's research attempt to answer the question: What are the cellular mechanisms of disease states in the brain? His lab is focused on the cellular neurobiology related to neurodegenerative diseases such as Alzheimer’s disease and prion diseases. By studying the molecular function and processing of proteins involved in these diseases, Norstrom hopes to gain insight into their development and, ultimately, add to the knowledge on how to most effectively and safely treat them. To approach these complex themes, Norstrom​ has utilized molecular genetics and protein biochemistry along with proteomics techniques and fluorescence microscopy. Using cell culture techniques and animal models, his lab will continue to elucidate the function and dysfunction of proteins and cells involved in neurodegenerative disease.

Select Publications

Chang JL, Hinrich AJ, Roman B, Norrbom M, Rigo F, Marr RA, Norstrom EM, Hastings ML. Targeting Amyloid-β Precursor Protein, APP, Splicing with Antisense Oligonucleotides Reduces Toxic Amyloid-β Production. Mol Ther. 2018 Jun 6;26(6):1539-1551. doi: 10.1016/j.ymthe.2018.02.029.

Cali I, Mikhail F, Qin K, Gregory C, Solanki A, Martinez MC, Zhao L, Appleby B, Gambetti P, Norstrom E, Mastrianni JA. Impaired transmissibility of atypical prions from genetic CJD(G114V). Neurol Genet. 2018 Aug 7;4(4):e253. ​

Norstrom E. Metabolic processing of the amyloid precursor protein – new pieces of the Alzheimer’s puzzle. Discovery Medicine. 2017 Apr 23(127);269-276.

Philibert KD, Marr RA, Norstrom EM*, Glucksman MJ*. Identification and characterization of Aβ peptide interactors in Alzheimer's disease by structural approaches. Frontiers in Aging Neuroscience. 2014 Oct 9;6:265.

Norstrom EM, Zhang C, Tanzi R, Sisodia SS. Identification of NEEP21 as an APP-interacting protein in vivo that modulates amyloidogenic processing in vitro. J Neurosci. 2010 Nov 17;30(46):15677-85. ​

Professional Society Memberships

• Society for Neuroscience
• American Association for the Advancement of Science
• American Society for Cell Biology