Ari Koskelainen

Peer-reviewed scientific articles

Journal article-refereed, Original research

A Novel Method for Mouse Retinal Temperature Determination Based on ERG Photoresponses

Pitkänen, Marja; Kaikkonen, Ossi; Koskelainen, Ari

2017 in ANNALS OF BIOMEDICAL ENGINEERING (Springer Netherlands)

ISSN: 0090-6964

Lack of P4H-TM in mice results in age-related retinal and renal alterations

Leinonen, Henri; Rossi, Maarit; Salo, Antti; Tiainen, Päivi; Hyvärinen, Jaana; Pitkänen, Marja; Sormunen, Raija; Miinalainen, Ilkka; Zhang, Chi; Soininen, Raija; Kivirikko, Kari; Koskelainen, Ari; Tanila, Heikki; Myllyharju, Johanna; Koivunen, Peppi

2016 in HUMAN MOLECULAR GENETICS (Oxford University Press)

ISSN: 0964-6906

A novel Ca2+-feedback mechanism extends the operating range of mammalian rods to brighter light

Vinberg, Frans; Turunen, Teemu; Heikkinen, Hanna; Pitkänen, Marja; Koskelainen, Ari

2015 in JOURNAL OF GENERAL PHYSIOLOGY (Rockefeller University Press)

ISSN: 0022-1295

Flash responses of mouse rod photoreceptors in the isolated retina and corneal electro-retinogram: comparison of gain and kinetics

Heikkinen, Hanna; Vinberg, Frans; Pitkänen, Marja; Kommonen, Bertel; Koskelainen, Ari

2012 in INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE (ASSOC RESEARCH VISION OPHTHALMOLOGY INC)

ISSN: 0146-0404

Mesopic background lights enhance dark-adapted cone ERG flash responses in the intact mouse retina: a possible role for gap junctional decoupling

Heikkinen, Hanna; Vinberg, Frans; Nymark, Soile; Koskelainen, Ari

2011 in JOURNAL OF NEUROPHYSIOLOGY (American Physiological Society)

ISSN: 0022-3077

Calcium Sets the Physiological Value of the Dominant Time Constant of Saturated Mouse Rod Photo response Recovery

Vinberg, Frans; Koskelainen, Ari

2010 in PLOS ONE (PUBLIC LIBRARY SCIENCE)

Rod Phototransduction Determines the Trade-Off of Temporal Integration and Speed of Vision in Dark-Adapted Toads

Haldin, C.; Nymark, Soile; Aho, AC.; Koskelainen, Ari; Donner, K.

2009 in JOURNAL OF NEUROSCIENCE (SOC NEUROSCIENCE)

ISSN: 0270-6474

Temperature dependence of dark-adapted sensitivity and light-adaptation in photoreceptors with A1 visual pigments: A comparison of frog L-cones and rods

Heikkinen, Hanna; Nymark, Soile; Donner, K.; Koskelainen, Ari

2009 in VISION RESEARCH (Elsevier Limited)

ISSN: 0042-6989

Origin of the fast negative ERG component from isolated aspartate-treated mouse retina

Vinberg, Frans J.; Strandman, Satu; Koskelainen, Ari

2009 in JOURNAL OF VISION (Association for Research in Vision and Ophthalmology Inc.)

Mouse cone photoresponses obtained with electroretinogram from the isolated retina

Heikkinen, Hanna; Nymark, Soile; Koskelainen, Ari

2008 in VISION RESEARCH (Elsevier Limited)

ISSN: 0042-6989

A New Method for Measuring Free Drug Concentration: Retinal Tissue As a Biosensor

Nymark, Soile; Haldin, Charlotte; Tenhu, Heikki; Koskelainen, Ari

2006 in Investigative Ophthalmology & Visual Science (Elsevier Limited)

Light responses and light adaptation in rat retinal rods at different temperatures

Nymark, Soile; Heikkinen, Hanna; Haldin, C.; Donner, Kristian; Koskelainen, Ari

2005 in Physiological Society, London. (Elsevier Limited)

The photoactivation energy of the visual pigment in two spectrally different populations of Mysis relicta (Crustacea, Mysida)

Pahlberg, J.; Lindström, M.; Ala-Laurila, P.; Fyhrquist-Vanni, N.; Koskelainen, Ari; Donner, K.

2005 in Journal of Comparative Physiology A: sensory, neural, and behavioral physiology (Elsevier Limited)

Thermal Activation and Photoactivation of Visual Pigments

Ala-Laurila, Petri; Donner, Kristian; Koskelainen, Ari

2004 in BIOPHYSICAL JOURNAL (CELL PRESS)

On the relation between the photoactivation energy and the absorbance spectrum of visual pigments

Ala-Laurila, Petri; Pahlberg, Johan; Koskelainen, Ari; Donner, Kristian

2004 in VISION RESEARCH (Elsevier Limited)

Binding of 3-isobutyl-1-methylxanthine into copolymers of N-isopropylacrylamide

Kivela, Mirja; Tenhu, Heikki; Koskelainen, Ari

2004 in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (Elsevier Science B.V.)

The thermal contribution to photoactivation in A2 visual pigments studied by temperature effects on spectral properties

Ala-Laurila, Petri; Albert, Rauli-Jan; Saarinen, Pia; Koskelainen, Ari; Donner, Kristian

2003 in VISUAL NEUROSCIENCE (Cambridge Univ Press)

Temperature effects on spectral properties of red and green rods in toad retina

Ala-Laurila, Petri; Saarinen, Pia; Albert, Rauli; Koskelainen, Ari; Donner, Kristian

2002 in VISUAL NEUROSCIENCE (Cambridge Univ Press)

Measurement of thermal contribution to photoreceptor sensitivity

Koskelainen, Ari; Ala-Laurila, P.; Fyhrquist, N.; Donner, K.

2000 in NATURE (NATURE PUBLISHING GROUP)

Light adaption of cone photoresponses studied at the photoreceptor and ganglion cell levels in the frog retina

Donner, K.; Hemilä, S.; Koskelainen, A.

1998 in VISION RESEARCH (Elsevier Limited)

pH in retinal rod photoreceptors: regulation and effects of light responses

Donner, K.; Koskelainen, A.; Ruusuvuori, E.; Saarikoski, J.

1997 in Acta Physiologica Scandinavica (Elsevier Limited)

Light adaptation in frog cones deviates from Weber law in a temperature-dependent way

Koskelainen, A.; Hemilä, S.; Donner, K.

1997 in PERCEPTION (SAGE PUBLICATIONS LTD)

Regulation of intracellular pH in isolated salamander retinal rods

Saarikoski, J.; Ruusuvuori, E.; Koskelainen, A.; Donner, K.

1997 in Journal of Physiology (London) (SAGE PUBLICATIONS LTD)

pH changes in frog rods upon manipulation of putative pH-regulating transport mechanisms

Kalamkarov, G.; Pogozheva, I.; Shevchenko, T.; Koskelainen, A.; Hemilä, Simo; Donner, K.

1996 in VISION RESEARCH (Elsevier Limited)

Changes in retinal time scale under background light: observations on rods and ganglion cells in the frog retina

Donner, K.; Koskelainen, A.; Djuspsun, K.; Hemilä, S.

1995 in VISION RESEARCH (Elsevier Limited)

Modulation of phototransduction in vertebrate photoreceptor cells: roles of SH-groups of the light-sensitive channel and of pH regulating transport mechaanisms

Koskelainen, A.

1995 in Acta Polytechnica Scandinavica (Elsevier Limited)

Changes in the light-sensitive current of salamander rods upon manipulation of putative pH-regulating mechanisms in the inner and outer segment

Koskelainen, A.; Donner, K.; Kalamkarov, G.; Hemilä, S.

1994 in VISION RESEARCH (Elsevier Limited)

Spectral sensitivities of short- and long-wavelength sensitive cone mechanisms in the frog retina

Koskelainen, A.; Hemilä, Simo T.; Donner, K.

1994 in Acta Physiologica Scandinavica (Elsevier Limited)

pH regulation in frog cones studied by mass receptor photoresponses from the isolated retina

Koskelainen, Ari; Donner, K.; Lerber, T.; Hemilä, S.

1993 in VISION RESEARCH (Elsevier Limited)

ISSN: 0042-6989

On the relation between ERG waves and retinal function: inverted rod photoresponses from the frog retina

Donner, K.; Hemilä, S.; Koskelainen, Ari

1992 in VISION RESEARCH (Elsevier Limited)

ISSN: 0042-6989

Sulfhydryl binding reagents increase the conductivity of the light-sensitive channel and inhibit phototransduction in retinal rods

Donner, K.; Hemilä, S.; Kalamkarov, G.; Koskelainen, Ari; Pogozheva, I.; Rebrik, T.

1990 in EXPERIMENTAL EYE RESEARCH (Academic Press Inc.)

ISSN: 0014-4835

Rod phototransduction modulated by bicarbonate in the frog retina: roles of carbonic anhydrase and bicarbonate exchange

Donner, K.; Hemilä, S.; Kalamkarov, G.; Koskelainen, Ari; Shevchenko, T.

1990 in Journal of Physiology (London) (Academic Press Inc.)

Effects of sulfhydryl binding reagents on the photoresponses of amphibian retinal rods

Donner, K.; Hemilä, S.; Koskelainen, Ari

1989 in COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A: MOLECULAR AND INTEGRATIVE PHYSIOLOGY (Elsevier Inc.)

ISSN: 1095-6433

Temperature-dependence of rod photoresponses from the aspartate-treated retina of the frog (Rana temporaria)

Donner, K.; Hemilä, S.; Koskelainen, Ari

1988 in ACTA PHYSIOLOGICA (Wiley-Blackwell)

ISSN: 1748-1708

Transient sensitivity reduction and biphasic photoresponses observed when frog retinal rods are oxidized

Donner, K.; Hemilä, S.; Koskelainen, Ari

1987 in COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A: MOLECULAR AND INTEGRATIVE PHYSIOLOGY (Elsevier Inc.)

ISSN: 1095-6433

Conference proceedings

Comparison of transretinal mouse rod ERG with local ERG across photoreceptor outer segments

Turunen, Teemu T.; Koskelainen, Ari O.

2013

Sensitivity Regulation In Mouse Cones Expressing Human Red Opsin

Heikkinen, Hanna; Turunen, Teemu; Vinberg, Frans; Koskelainen, Ari

2012

Modulation of Dim Flash Responses by Lowered Extracellular Calcium in GCAP-/- Mouse Rods

Vinberg, Frans; Heikkinen, Hanna; Koskelainen, Ari

2012

The sensitivity and kinetics of mouse rod photoreceptors recorded with Erg in vivo and across the isolated retina.

Heikkinen, Hanna; Vinberg, Frans; Pitkänen, Marja; Kommonen, Bertel; Koskelainen, Ari

2011

Extensive modulation of R* but not PDE* Lifetime by light in mouse rods when registered in the intact retina.

Vinberg, Frans; Heikkinen, Hanna; Koskelainen, Ari

2011

Warming Desensitizes frog l-cones more than rods due to stronger intrinsic "dark light"

Heikkinen, Hanna; Nymark, Soile; Donner, Christian; Koskelainen, Ari

2008

Rod Photoresponse Kinetics Explain Temporal Integration at the Behavioral Level in Dark-Adapted Toads

Nymark, Soile; Haldin, Charlotte; Aho, Ann-Christine; Koskelainen, Ari; Donner, Kristian

2008

The nose component in mouse ERG responses

Vinberg, Frans; Koskelainen, Ari

2008

Calcium Shortens the Time Constant of Mouse Rod Saturated Photoresponse Recovery

Vinberg, Frans; Sahala, Elina; Koskelainen, Ari

2008

IBMX biomarker for biocompability with rat retina rod cells

Koskelainen, Ari

2006

Are calcium-dependent mechanisms selective for calcium in rod phototransduction?

Koskelainen, Ari

2006

The Fast Component in Saturated Mouse ERG Responses

Vinberg, Frans; Mäki, Hanna; Heikkinen, Hanna; Koskelainen, Ari

2006

Further studies on mouse n-wave

Vinberg, Frans; Mäki, Hanna; Koskelainen, Ari

2005

On the relation between thermal and photic activation of visual pigments

Ala-Laurila, Petri; Donner, Kristian; Koskelainen, Ari

2004

Sensitivity and kinetics in murine rods: a modelling study

Heikkinen, Hanna; Nymark, Soile; Donner, Kristian; Koskelainen, Ari

2004

A new method for measuring free drug concentration in retinal tissue

Koskelainen, Ari; Nymark, Soile; Haldin, Charlotte; Tenhu, Heikki

2002

On the relation between spectral and thermal properties of visual pigments

Donner, Kristian; Ala-Laurila, Petri; Albert, Rauli; Saarinen, Pia; Pahlberg, Johan; Fyhrquist-Vanni, Nanna; Lindström, Magnus; Govardovskii, Victor; Koskelainen, Ari

2001

Temperature effects on spectral sensitivity in two subspecies of Mysis relicta

Pahlberg, Johan; Lindström, Magnus; Ala-Laurila, Petri; Albert, Rauli; Fyhrquist-Vanni, Nanna; Koskelainen, Ari; Donner, Kristian

2001

The temperature-dependence of the spectral sensitivity of visual pigments: an interspecies comparison

Saarinen, Pia; Ala-Laurila, Petri; Albert, Rauli; Fyhrquist-Vanni, Nanna; Govardovskii, Victor; Koskelainen, Ari; Donner, Kristian

2001

Activation energy of rhodopsin in rods of the cane toad, Bufo marinus

Ala-Laurila, P.; Albert, R.; Donner, K.; Koskelainen, Ari

2000

Crown ether substituted water soluble graft copolymers

Koskelainen, A.; Strandman, Satu; Tenhu, H.

2000

Thermally responsive polymer gels and latex particles for controlled drug delivery

Salonen, S.; Tenhu, H.; Koskelainen, A.

1999

Non-refereed scientific articles

Unrefereed conference proceedings

The use of ERG for determining the temperature of RPE cells

Pitkänen, Marja; Koskelainen, Ari

2013

Method for determinening the rate of spontaneous cGMP hydrolysis

Turunen, Teemu; Koskelainen, Ari

2013

Scientific books (monographs)

Book (editor)

Seminar on Biomedical Engineering 2007

Lilja, Mikko; Koskelainen, Ari; Ilmoniemi, Risto

2007

ISBN: 978-951-22-8833-5

Seminar on Biomedical Engineering 2006

Lilja, Mikko; Koskelainen, Ari; Ilmoniemi, Risto

2006

ISBN: 951-22-8213-5

Publications intended for professional communities

Published development or research report

Adaptation of Mouse Cones to Steps of Light after Suppression of Rods, Measured with Electroretinogram from isolated Retina

Heikkinen, Hanna; Vinberg, Frans; Nymark, Soile; Koskelainen, Ari

2009

Temporal Integration in Dark-Adapted Toads at the Behavioral "Output" and Rod "Input" Levels Vision

Nymark, Soile; Haldin, C.; Aho, A-C.; Koskelainen, Ari; Donner, K.

2009

Gene Therapy Studies for USH3: Characterization of the Knockout Mouse Retina and Search for an efficient AAV Vector

Pietola, L.; Jalkanen, R.; Vinberg, Frans; Koskelainen, Ari; Dinculescu, A.; Hauswirth, W.W.; Flannery, J.; Jero, J.; Sankila, E-M.

2009

Origin of the Nose Component in Mouse ERG

Vinberg, Frans; Koskelainen, Ari

2009

Temperature Resembles Background Light in Its Effects on Fractional Photoresponses of Frog L-Cones

Nymark, Soile; Heikkinen, Hanna; Donner, Kristian; Koskelainen, Ari

2008

Cobalt Can Replace Calcium in Mouse Rod Phototransduction and Light Adaptation

Vinberg, Frans; Sahala, Elina; Koskelainen, Ari

2007

The Fast Nose Component in the Mouse Electroretinogram Affects the Rod Photoresponse Amplitude Obtained by the Paired Flash Method

Mäki, Hanna; Vinberg, Frans; Heikkinen, Hanna; Koskelainen, Ari

2006

Cone ERG Photoresponses From the Isolated Mouse Retina

Nymark, Soile; Kärkäs, Petri; Koskelainen, Ari

2006

The Specific Absorbance of Rat Rods

Nymark, Soile; Heikkinen, Hanna; Donner, Kristian; Koskelainen, Ari

2005

Temporal summation: blessing or curse for the hunting toad

Haldin, Charlotte; Aho, Ann-Christine; Donner, Kristian; Koskelainen, Ari

2004

A method for measuring free model drug concentration in retinal tissue

Koskelainen, Ari; Nymark, Soile; Tenhu, Heikki

2004

The photoactivation energy of the visual pigment in two populations of Mysis relicta (Mysidacea, Crustacea) determined from temperature effects on spectral sensitivity

Pahlberg, Johan; Lindström, Magnus; Ala-Laurila, Petri; Fyhrquist-Vanni, Nanna; Koskelainen, Ari; Donner, Kristian

2004

Comparison of mouse and rat rod photoresponse kinetics and sensitivity at different temperatures

Suominen, Hanna; Nymark, Soile; Donner, Kristian; Koskelainen, Ari

2004

The Effect of the Chromophore Switch From A1 to A2 on Spectral and Thermal Properties of the Rod Visual Pigment in the Bullfrog, Rana catesbeiana

Ala-Laurila, Petri; Albert, Rauli; Saarinen, Pia; Koskelainen, Ari; Donner, Kristian

2003

The general anaesthetic propofol increases the amplification factor of phototransduction in dark-adapted mouse rods

Koskelainen, Ari; Pahlberg, Johan

2003

Light-adaptation of mammalian retinal rods revisited

Donner, Kristian; Nymark, Soile; Haldin, Charlotte; Suominen, Hanna; Koskelainen, Ari

2002

Light-adaptation in rat rods at different temperatures

Nymark, Soile; Haldin, Charlotte; Suominen, Hanna; Donner, Kristian; Koskelainen, Ari

2002

Temperature-dependent effects on sensitivity in frog cones

Suominen, Hanna; Nymark, Soile; Donner, Kristian; Koskelainen, Ari

2002

Measurement of the activation energy of rhodopsin in rods of the toad, Bufo marinus

Ala-Laurila, Petri; Albert, R.; Donner, K.; Koskelainen, A.

2000

Spectral and thermal properties of visual pigments bear no simple relation

Ala-Laurila, P.; Albert, R.; Donner, Kristian; Koskelainen, A.

2000

Crown ether substituted water soluble graft copolymers

Koskelainen, A.; Strandman, Satu; Tenhu, H.

2000

Water soluble copolymers wih pendant crown ethers

Koskelainen, A.; Strandman, Satu; Tenhu, H.

2000

Crown ether substituted water soluble graft copolymers

Koskelainen, A.; Strandman, Satu; Tenhu, H.

2000

Thermal energy contributes to visual excitation similarly in photoreceptor cells with different spectral sensitivities

Donner, K.; Ala-Laurila, P.; Fyhrquist, N.; Koskelainen, A.

1999

A new look at the light-adaptation of cones

Donner, K.; Hemilä, S.; Koskelainen, A.

1997

Temperature dependence of light responses in frog cones

Koskelainen, A.; Hemilä, S.; Donner, K.

1997

Public artistic and design activities

Public contribution to artistic work

SPACES OF THE ABNORMAL, POVEGLIA II NIGHT PIECES – 3 X SPATIAL ACCESS TO “THE VENICE”

Ikonen, Liisa; Koskelainen, Ari

2017

Retinal temperature determination ex vivo based on ERG photoresponses

Pitkänen, Marja; Kaikkonen, Ossi; Koskelainen, Ari O.

2015 in INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE (ASSOC RESEARCH VISION OPHTHALMOLOGY INC)

ISSN: 0146-0404

Determination of basal PDE activity in WT, GCAPs(-/-) and GCAPs(-/-) rec(-/-) mice rods

Turunen, Teemu Tapio; Antikainen, Anni Aleksandra Villentytar; Koskelainen, Ari O.

2015 in INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE (ASSOC RESEARCH VISION OPHTHALMOLOGY INC)

ISSN: 0146-0404