Yun Chau Long

Education

• PhD, Karolinska Institute, Sweden 2007
• MSc, National University of Singapore 2002
• BSc, National University of Singapore 1996

Professional Experience

• Senior Lecturer, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS. 2017 – present
• Assistant Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS. 2011 – 2017
• Research Scientist, Division of Endocrinology, Lilly Research Laboratories, Eli Lilly Corporate Center USA 2010 – 2011
• Post-doctoral Fellow, Howard Hughes Medical Institute, Children’s Hospital Boston, Harvard Medical School USA 2007 – 2009

Research Interest

• Insulin/ insulin-like growth factor signaling and cellular nutrient sensing.
• Regulation of energy substrates utilization and its role in cellular signaling.
• Transcriptional regulation of metabolic network and gene expression.
• Role of NAD/ NADH metabolism in nutrient-gene communication.
• Implications of altered metabolic program in skeletal muscle and metabolic disorders such as insulin resistance and diabetes.

Selected Publications

• Yu X, Long YC. Autophagy modulates amino acid signaling network in myotubes: differential effects on mTORC1 pathway and the integrated stress response. FASEB J. 2014 Nov 5. pii: fj.14-252841.
• Long YC, Tan TM, Takao I, Tang BL. The biochemistry and cell biology of aging: metabolic regulation through mitochondrial signaling. Am J Physiol Endocrinol Metab. 2014; 306(6):E581-91.
• Raichur S, Teh SH, Ohwaki K, Gaur V, Long YC, Hargreaves M, McGee SL, Kusunoki J. Histone deacetylase 5 regulates glucose uptake and insulin action in muscle cells. J Mol Endocrinol. 2012; 49(3):203-11
• Long YC, Kharitonenkov A. Hormone-like fibroblast growth factors and metabolic regulation. Biochim Biophys Acta. 2011;1812(7):791-5.
• Long YC, Kostovski E, Boon H, Hjeltnes N, Krook A, and Ulrika Widegren. Differential expression of metabolic genes essential for glucose and lipid metabolism in skeletal muscle from spinal cord injured subjects. J Appl Physiol. 2011; 110(5):1204-10.
• Long YC, Cheng Z, Copps KD, White MF. Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via Akt and AMPK pathways. Mol Cell Biol. 2011; 31(3):430-41.