Xiaoyuan (Shawn) Chen

Prof. Xiaoyuan (Shawn) Chen received his PhD in Chemistry from the University of Idaho (1999). After two postdocs at Syracuse University and Washington University in St. Louis, he started his Assistant Professorship in 2002 and joined Stanford in 2004. He was promoted to Associate Professor in 2008. He then moved to NIH in 2009 and became a Senior Investigator and Chief of the Laboratory of Molecular Imaging and Nanomedicine (LOMIN) at the National Institute of Biomedical Imaging and Bioengineering (NIBIB), NIH. He is currently Nasrat Muzayyin Professor in Medicine and Technology, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore. Dr. Chen has published over 850 peer-reviewed papers (H-index: 150, total citations > 83,000 based on google scholar) and numerous books and book chapters. He is the founding editor of journal “Theranostics” (IF = 8.579 based 2020 Journal Citation Report). He was elected as AIMBE Fellow (2017) and SNMMI Fellow (2020), received SNMMI Michael J. Welch Award (2019), ACS Bioconjugate Chemistry Lecturer Award (2016), NIH Director’s Award (2014), NIBIB Mentor Award (2012). He is also the Past President of Chinese-American Society of Nuclear Medicine and Molecular Imaging (CASNMMI), Past President of the Radiopharmaceutical Science Council (RPSC), Society of Nuclear Medicine and Molecular Imaging (SNMMI), and Past President of the Chinese American Society of Nanomedicine and Nanobiotechnology (CASNN).

Research Area

Cancer: Diagnostics and Therapeutics, Others, Others: Gene/drug delivery, Others: Nanomedicine, Others: Radionuclide therapy

Cardiovascular Diseases: Imaging and Surgical, Therapy

Research Interest

• Molecular imaging probe development
• Modification of biomolecules for improved PK/PD
• Nanomedicine for gene and drug delivery (GDD)
• Ultrasensitive nanobiosensors for biomarker detection

Education

• PhD University of Idaho (1996 — 1999)
• Huangqiao Middle School
• Huangqiao Middle School

Companies

• Nasrat Muzayyin Professor in Medicine and Technology National University of Singapore (2020)
• Senior Investigator and Lab Chief NIH (2009 — 2020)
• Associate Professor Stanford University Medical Center (2004 — 2009)

Recent Publications

• Lin L, Wang S, Deng H, Yang W, Rao L, Tian R, Liu Y, Yu G, Zhou Z, Song J, Yang HH, Chen ZY, Chen X. Endogenous Labile Iron Pool-Mediated Free Radical Generation for Cancer Chemodynamic Therapy. J Am Chem Soc. 2020;142(36):15320-15330.
• Li L, Zou J, Dai Y, Fan W, Niu G, Yang Z, Chen X. Burst release of encapsulated annexin A5 in tumours boosts cytotoxic T-cell responses by blocking the phagocytosis of apoptotic cells. Nat Biomed Eng. 2020;4(11):1102-1116.
• Recent Advances in Stimuli-Responsive Platforms for Cancer Immunotherapy. Li L, Yang Z, Chen X. Recent Advances in Stimuli-Responsive Platforms for Cancer Immunotherapy. Acc Chem Res. 2020 Oct 20;53(10):2044-2054.
• Rao L, Wu L, Liu Z, Tian R, Yu G, Zhou Z, Yang K, Xiong HG, Zhang A, Yu GT, Sun W, Xu H, Guo J, Li A, Chen H, Sun ZJ, Fu YX, Chen X. Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis. Nat Commun. 2020;11(1):4909. DOI: 10.1038/s41467-020-18626-y.
• Chen H, Zhang W, Zhu G, Xie J, Chen X. Rethinking cancer nanotheranostics. Nat Rev Mater. 2017;2:17024. doi: 10.1038/natrevmats.2017.24.

Selected Publications

• Rao L, Xia S, Xu W, Tian R, Yu G, Gu C, Pan P, Meng QF, Cai X, Qu D, Lu L, Xie Y, Jiang S, Chen X. Decoy nanoparticles protect against COVID-19 by concurrently adsorbing viruses and inflammatory cytokines. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27141-27147.
• Chen W, Cai B, Geng Z, Chen F, Wang Z, Wang L, Chen X. Reducing False Negatives in COVID-19 Testing by Using Microneedle-Based Oropharyngeal Swabs. Matter. 2020;3(5):1589-1600.
• Deng H, Yang W, Zhou Z, Tian R, Lin L, Ma Y, Song J, Chen X. Targeted scavenging of extracellular ROS relieves suppressive immunogenic cell death. Nat Commun. 2020;11(1):4951.
• Wu D, Wang S, Yu G, Chen X. Cell Death Mediated by the Pyroptosis Pathway with the Aid of Nanotechnology: Prospects for Cancer Therapy. Angew Chem Int Ed Engl. 2020 Sep 7.
• Liu Q, Zang J, Sui H, Ren J, Guo H, Wang H, Wang R, Jacobson O, Zhang J, Cheng Y, Zhu Z, Chen X. Peptide Receptor Radionuclide Therapy of Late-stage Neuroendocrine Tumor Patients with Multiple Cycles of 177Lu-DOTA-EB-TATE. J Nucl Med. 2020 Aug 21:jnumed.120.248658.