Thomas Dick

Dr Dick has 20 years of experience in mycobacteriology and antimycobacterial drug discovery. Prior to his current appointments as Member at the Center for Discovery and Innovation, Hackensack Meridian Health (CDI) and Professor at Hackensack Meridian School of Medicine and Georgetown University, he was Tuberculosis (TB) disease area head at Novartis and served as Associate Professor at Rutgers and the National University of Singapore. His research focuses on the discovery of new antibiotics for the treatment of TB and lung disease caused by Non-Tuberculous Mycobacteria (NTM). At CDI he established a fully enabled TB and NTM drug discovery platform for the discovery of target-lead couples and the delivery of preclinical development candidates. The platform includes mycobacterial strain collections, a range of in vitro potency assays, and in vivo (mouse) pharmacology and efficacy models. Target deconvolution and resistance analysis complement his compound profiling capabilities. With medicinal chemistry partners from industry and academia he developed a portfolio of de novo and repositioning drug discovery projects. Dr Dick published over 150 papers in the field of discovery, mechanism of action & resistance of antibacterials with an h-index of 49.

Expertise

Mycobacteriology, Antibiotics, Resistance, Mechanism of Action, Discovery

Research Techniques

Bacteriology, Chemical Biology, Genetics, Biochemistry

Interests

TB (Tuberculosis) and NTM (Non-tuberculous-mycobacteria) Drug Discovery

Companies

• Professor Georgetown University (2020)
• Professor Hackensack Meridian School of Medicine (2019)
• Member Center for Discovery and Innovation (2019)
• Toh Chin Chye Visiting Professor National University of Singapore (2017 — 2020)
• Associate Professor & Director Antimicrobial Drug Discovery Rutgers University (2017 — 2019)
• Associate Professor & Director BSL3 Core Facility National University of Singapore (2011 — 2017)
• Head Tuberculosis Unit Novartis (2003 — 2011)
• Principal Investigator - Mycobacteriology lab A*STAR - Agency for Science, Technology and Research (1996 — 2003)
• Postdoctoral Research Fellow A*STAR - Agency for Science, Technology and Research (1990 — 1996)

Education

• PhD Heidelberg University (1981 — 1990)
• Abitur / A level Helmholtz Gymnasium Heidelberg (1972 — 1981)