Silvia Finnemann

EDUCATION

• Diploma in Biochemistry, Free University of Berlin, Germany, 1991.
• Ph.D. in Biochemistry, Department of Chemistry, Free University of Berlin, Germany, 1995.

SELECTED PUBLICATIONS

Vives-Bauza, C, M Anand, AK Shirazi, J Magrane, J Gao, H Vollmer-Snarr, G Manfredi & SC Finnemann. The age lipid A2E and mitochondrial dysfunction synergistically impair phagocytosis by retinal pigment epithelial cells. J. Biol. Chem. 283(36):24770-24780 (2008).

Finnemann, SC, & Y Chang. Photoreceptor-RPE Interactions: Physiology and Molecular Mechanisms. Ch. 4 in "Visual Transduction and Non Visual Light Perception" J. Tombran-Tink & C. J. Barnstable, Ed. (2008).

Nandrot, EF, Y Chang & SC Finnemann. avb5 integrin receptors at the apical surface of the RPE: one receptor, two functions. Adv Exp Med Biol. 613:369-75 (2008).

Nandrot, EF, & SC Finnemann. Lack of avb5 integrin receptor or its ligand MFG-E8: distinct effects on retinal function. Ophthalmic Res. 40:120-3 (2008).

Chang, Y, & SC Finnemann. Tetraspanin CD81 is required for the avb5 integrin-dependent particle binding step of retinal phagocytosis. J. Cell Sci. 120(17):3053-3063 (2007).

Nandrot, EF, M Anand, D Almeida, K Atabai, D Sheppard & SC Finnemann. Essential role for MFG-E8 as ligand for avb5 integrin in diurnal retinal phagocytosis. Proc. Natl. Acad. Sci. USA. 104(29):12005-12010 (2007).

Lakkaraju, A, SC Finnemann & E Rodriguez-Boulan. The lipofuscin fluorophore A2E perturbs cholesterol metabolism in retinal pigment epithelial cells. Proc. Natl. Acad. Sci. USA. 104(26):11026-11031 (2007).

Finnemann, SC, & EF Nandrot. MerTK activation during RPE phagocytosis in vivo requires avb5 integrin. Adv. Exp. Med. Biol. 572: 499-504 (2006).

Nandrot, EF, & SC Finnemann. Altered rhythm of photoreceptor outer segment phagocytosis in b5 integrin knockout mice. Adv. Exp. Med. Biol. 572:119-124 (2006).

Sun, M, SC Finnemann, M Febbraio, L Shan, SP Annangudi, EA Podrez, G Hoppe, R Darrow, DT Organisciak, RG Salomon, RL Silverstein & SL Hazen. Light-induced oxidation of photoreceptor outer segment phospholipids generates ligands for CD36-mediated phagocytosis by retinal pigment epithelium. J. Biol. Chem. 281:4222-4230 (2006).

Nandrot, EF, M Anand, M Sircar, & SC Finnemann. Novel function for avb5 integrin in retinal adhesion and its diurnal peak. Am. J. Phys. Cell Phys. 290: C1256 –C1262 (2006).

Nandrot, EF, YH Kim, SE Brodie, X Huang, D Sheppard & SC Finnemann. Loss of synchronized RPE phagocytosis and age-related blindness in mice lacking avb5 integrin. J. Exp. Med. 200:1539-1545 (2004) (cover image).

Finnemann, SC. Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptors. EMBO J. 16:4143-4154 (2003).