Paul Macary

Affliations:

• LSI Immunology Programme
• NUS Graduate School for Integrative Sciences and Engineering

Research Interest

• Associate Professor Paul MacAry received his BSc (Hons) in Molecular Genetics from the Glasgow University in 1993 and his PhD in Immunology from GKT, University of London in 1998. He performed post-doctoral researches in the Cambridge University Institute for Medical Research (CIMR) and since 2005 has been an independent investigator in the Department of Microbiology and Immunology programme at the National University of Singapore (NUS). The multi-disciplinary research in his laboratory covers the entire spectrum of scientific endeavour, from basic research to industrial applications with an emphasis on antibody biology, immune repertoire mapping and protein engineering. His laboratory has ongoing collaborations with Roche Pharma, GlaxoSmithKline, Chugai and Becton Dickinson. Paul was a founding member and Meetings Secretary for the Singaporean Society of Immunology (SSI)-Singapore’s first international learned society and the founding scientist for two biotechnology companies, BSCR LTD founded in Cambridge in 2004 and Antibody Cradle LTD founded in Singapore in 2012. His research has been featured in covering articles on the BBC and Reuters and he has published several manuscripts in top international journals including Science, Science Translational Medicine, Nature Medicine, Immunity, Hepatology, PNAS and Blood with four included in the staff of 1000.

Representative Publications

• Rivino L, Kumaran EA, Thein TL, Too CT, Gan VC, Hanson BJ, Wilder-Smith A, Bertoletti A, Gascoigne NR, Lye DC, Leo YS, Akbar AN, Kemeny DM, MacAry PA (2015) Virus-specific T lymphocytes home to the skin during natural dengue infection. Science Translational Medicine, 7(278): 278ra35.
• Lin DC, Meng X, Hazawa M, Nagata Y, Varela AM, Xu L, Sato Y, Liu LZ, Ding LW, Sharma A, Goh BC, Lee SC, Petersson BF, Yu FG, MacAry P, Oo MZ, Ha CS, Yang H, Ogawa S, Loh KS, Koeffler HP (2014) The genomic landscape of nasopharyngeal carcinoma. Nature Genetics, 46(8): 866-71.
• Teoh EE, Kukkaro P, Teo EW, Lim APC, Tan TT, Yip A, Schul W, Aung M, Kostyuchenko VA, Leo YS, Chan SH, Smith KGC, Chan AHY, Zou G, Ooi EE, Kemeny DM, Tan GK, Ng JKW, Ng ML, Alonso S, Fisher D, Shi PY, Lok SM, Macary PA (2012) Structural Basis for Serotype-Specific Neutralization of Dengue Virus by a Natural Human Antibody. Science Translational Medicine, 4(139): 139ra83.
• Rivino L, Kumaran EA, Jovanovic V, Nadua K, Teo EW, Pang SW, Teo GH, Gan VC, Lye DC, Leo YS, Hanson BJ, Smith KG, Bertoletti A, Kemeny DM, MacAry PA (2013) Differential targeting of viral components by CD4+ versus CD8+ T lymphocytes in dengue virus infection. Journal of Virology, 87(5): 2693-706.
• Rivino L, Tan AT, Chia A, Kumaran EA, Grotenbreg GM, MacAry PM, Bertoletti A (2013) Defining CD8+ T Cell Determinants during Human Viral Infection in Populations of Asian Ethnicity. Journal of Immunology, 191(8): 4010-19.
• Ho AW, Prabhu N, Betts RJ, Ge MQ, Dai X, Hutchinson PE, Lew FC, Wong KL, Hanson BJ, MacAry PA, Kemeny DM (2011) Lung CD103+ Dendritic Cells Efficiently Transport Influenza Virus to the Lymph Node and Load Viral Antigen onto MHC Class I for Presentation to CD8 T Cells. Journal of Immunology, 187(11): 6011-21. staff of 1000.
• McKinney EF, Lyons PA, Carr EJ, Hollis JL, Jayne DR, Willcocks LC, Koukoulaki M, Brazma A, Jovanovic V, Kemeny DM, Pollard AJ, MacAry PA, Chaudhry AN, Smith KG (2010) A CD8+ T cell transcription signature predicts prognosis in autoimmune disease. Nature Medicine, 16(5): 586-91, 1p following 591.
• MacAry PA*, Floto RA*, Boname JM, Mien TS, Kampmann B, Hair JR, Huey OS, Houben EN, Pieters J, Day C, Oehlmann W, Singh M, Smith KG, Lehner PJ (2006) Dendritic cell stimulation by mycobacterial HSP70 is mediated through CCR5. Science, 314(5798): 454-8. (*=equal first author). staff of 1000.
• Floto RA, Clatworthy MR, Heilbronn KR, Rosner DR, MacAry PA, Rankin A, Lehner PJ, Ouwehand WH, Allen JM, Watkins NA, Smith KG (2005) Loss of function of a lupus-associated FcgammaRIIb polymorphism through exclusion from lipid rafts. Nature Medicine, 11(10): 1056-8.
• MacAry PA, Javid B, Floto RA, Smith KG, Oehlmann W, Singh M, Lehner PJ (2004) HSP70 peptide binding mutants separate antigen delivery from dendritic cell stimulation. Immunity, 20(1): 95-106. staff of 1000.