Myles Wolf

The focus of my research is disordered mineral metabolism across the spectrum of chronic kidney disease, including dialysis, kidney transplantation and earlier stages.

My research has been published in leading general medicine and subspecialty journals, including the New England Journal of Medicine, JAMA, the Journal of Clinical Investigation, Circulation, Cell Metabolism, Journal of the American Society of Nephrology, and Kidney International, among others.

My primary contributions have been in the area of hormonal regulation of phosphate homeostasis. I have helped to characterize the physiological role of fibroblast growth factor 23 in health and in chronic kidney disease, and the impact of elevated fibroblast growth factor 23 levels on adverse clinical outcomes in patients with kidney disease.

Education and Training

• Research Fellowship in Nephrology, Massachusetts General Hospital, 2000 - 2001
• Clinical Fellowship in Nephrology, Brigham and Women's Hospital, 1999 - 2000
• Internal Medicine Residency, Massachusetts General Hospital, 1996 - 1999
• M.Med.Sc., Harvard Medical School, 2002
• M.D., State University of New York at Brooklyn, 1996

Grants

• Duke CTSA (KL2)
• Duke CTSA (TL1)
• HiLo
• FGF23 and Cardiovascular Disease in CKD (CRIC)
• Role of FGF23 in Mineral Metabolism Across the Spectrum of Chronic Kidney Disease
• Pencast Videos to Boost Learning and Interest in Nephrology Among Internal Medicine Residents
• Molecular Mechanisms of Cardiac Injury Induced by FGF23 in the Settings of High Phosphate Diet and CKD
• Phosphate and FGF23: Dietary and Molecular Mediators of Health Disparities in Cardiovasular and Kidney Diseases (Center)
• Endocrinology and Metabolism Training Program
• Pilot Studies Targeting Mineral Metabolism in CKD
• Impact of phosphate and FGF23 reduction on intermediate end points in CKD

Publications

Amdur, RL, Feldman, HI, Dominic, EA, Anderson, AH, Beddhu, S, Rahman, M, Wolf, M, Reilly, M, Ojo, A, Townsend, RR, Go, AS, He, J, Xie, D, Thompson, S, Budoff, M, Kasner, S, Kimmel, PL, Kusek, JW, Raj, DS, and CRIC Study Investigators, . "Use of Measures of Inflammation and Kidney Function for Prediction of Atherosclerotic Vascular Disease Events and Death in Patients With CKD: Findings From the CRIC Study." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation 73, no. 3 (March 2019): 344-353.

Schrauben, SJ, Hsu, JY, Wright Nunes, J, Fischer, MJ, Srivastava, A, Chen, J, Charleston, J, Steigerwalt, S, Tan, TC, Fink, JC, Ricardo, AC, Lash, JP, Wolf, M, Feldman, HI, Anderson, AH, and CRIC Study Investigators, . "Health Behaviors in Younger and Older Adults With CKD: Results From the CRIC Study." Kidney International Reports 4, no. 1 (January 2019): 80-93.

Prasad, PV, Li, W, Raj, DS, Carr, J, Carr, M, Thacker, J, Li, L-P, Wang, C, Sprague, SM, Ix, JH, Chonchol, M, Block, G, Cheung, AK, Raphael, K, Gassman, J, Wolf, M, Fried, LF, Isakova, T, and CKD Optimal Management with BInders and NicotinamidE (COMBINE) study group, . "Multicenter Study Evaluating Intrarenal Oxygenation and Fibrosis Using Magnetic Resonance Imaging in Individuals With Advanced CKD." Kidney International Reports 3, no. 6 (November 2018): 1467-1472. (Letter)

Robinson-Cohen, C, Perwad, F, Wolf, MS, De Boer, IH, Kestenbaum, B, Lipworth, L, Hung, A, and Ikizler, TA. "Genetic Variants Associated with Circulating Parathyroid Hormone among Patients with Chronic Kidney Disease." Annual Meeting of the American-Society-for-Bone-and-Mineral-Research. Montreal, CANADA. September 28, 2018 - October 1, 2018.: WILEY, November 1, 2018.

Robinson-Cohen, C, Perwad, F, Wolf, MS, De Boer, IH, Kestenbaum, B, Lipworth, L, Hung, A, and Ikizler, TA. "Genetic Variants Associated with Circulating Parathyroid Hormone among Patients with Chronic Kidney Disease." Annual Meeting of the American-Society-for-Bone-and-Mineral-Research. Montreal, CANADA. September 28, 2018 - October 1, 2018.: WILEY, November 1, 2018.

Robinson-Cohen, C, Bartz, TM, Lai, D, Ikizler, TA, Peacock, M, Imel, EA, Michos, ED, Foroud, TM, Akesson, K, Taylor, KD, Malmgren, L, Matsushita, K, Nethander, M, Eriksson, J, Ohlsson, C, Mellström, D, Wolf, M, Ljunggren, O, McGuigan, F, Rotter, JI, Karlsson, M, Econs, MJ, Ix, JH, Lutsey, PL, Psaty, BM, de Boer, IH, and Kestenbaum, BR. "Genetic Variants Associated with Circulating Fibroblast Growth Factor 23." Journal of the American Society of Nephrology : Jasn 29, no. 10 (October 2018): 2583-2592.

Scialla, JJ, Brown, L, Gurley, S, Corcoran, DL, Bain, JR, Muehlbauer, MJ, O'Neal, SK, M O'Connell, T, Wolf, M, Melamed, ML, Hostetter, TH, and Abramowitz, MK. "Metabolic Changes with Base-Loading in CKD." Clinical Journal of the American Society of Nephrology : Cjasn 13, no. 8 (August 2018): 1244-1246.

Kolak, M, Bradley, M, Block, DR, Pool, L, Garg, G, Toman, CK, Boatright, K, Lipiszko, D, Koschinsky, J, Kershaw, K, Carnethon, M, Isakova, T, and Wolf, M. "Urban foodscape trends: Disparities in healthy food access in Chicago, 2007-2014." Health & Place 52 (July 9, 2018): 231-239.

Neuburg, S, Dussold, C, Gerber, C, Wang, X, Francis, C, Qi, L, David, V, Wolf, M, and Martin, A. "Genetic background influences cardiac phenotype in murine chronic kidney disease." July 2018.

Gerber, C, Cai, X, Lee, J, Craven, T, Scialla, J, Souma, N, Srivastava, A, Mehta, R, Paluch, A, Hodakowski, A, Frazier, R, Carnethon, MR, Wolf, MS, and Isakova, T. "Incidence and Progression of Chronic Kidney Disease in Black and White Individuals with Type 2 Diabetes." Clinical Journal of the American Society of Nephrology : Cjasn 13, no. 6 (June 2018): 884-892.