Markus Wenk

Affiliations

• Provost’s Chair, Yong Loo Lin School of Medicine, NUS
• Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.
• Professor, Department of Biological Sciences, Faculty of Sciences, NUS.
• Director and Principal Investigator ‘Singapore Lipidomics Incubator (SLING)’, Life Sciences Institute, NUS.
• Supervisor, NUS Graduate School for Integrative Sciences and Engineering (NGS), NUS.
• Privatdozent, University of Basel, Switzerland.
• Executive Editor, Progress in Lipid Research.

Research Interest

Application of lipid profiling (“lipidomics”) as a novel and independent approach for the systems level scale analysis of biological systems.

Selected Publications

• MR, Pellegrini L, Klenchin VA, Di Paolo G, Chang S, Daniell L, Arioka M, Martin TF, and De Camilli P (2001). PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse. Neuron 32, 79-88.
• Wenk MR, Lucast L, Di Paolo G, Romanelli AJ, Suchy SF, Nussbaum RL, Cline GW, Shulman GI, McMurray W, and De Camilli P (2003). Phosphoinositide profiling in complex lipid mixtures using electrospray ionization mass spectrometry. Nat Biotechnol 21, 813-817.
• Wenk MR (2005). The emerging field of lipidomics. Nat Rev Drug Discov. 7: 594-610.
• Guan XL, Souza CM, Pichler H, Funato K, Wenk MR and Riezman H. (2009). Functional Interactions between Sphingolipids and Sterols in Biological Membranes Regulating Cell Physiology. Molecular Biology of the Cell 20(7), 2083-2095.
• Wenk MR (2010). Lipidomics: New tools and applications. Cell. 143(6):888-95
• Shui G, Bendt AK, Jappar IA, Lim HM, Laneelle M, Hervé M, Via LE, Chua GH, Bratschi MW, Rahim SZ, Michelle AL, Hwang SH, Lee JS, Eum SY, Kwak HK, Daffé M, Dartois V, Michel G, Barry CE 3rd, Wenk MR (2012). Mycolic acids as diagnostic markers for tuberculosis case detection in humans and drug efficacy in mice. EMBO Mol Med 4(1):27-37