Mahmoud Pouladi

Education

• PhD The University of British Columbia (2004 — 2010)
• MSc McMaster University (2001 — 2003)
• BSc McMaster University (1997 — 2001)

Companies

• Associate Professor The University of British Columbia (2021)
• Assistant Professor National University of Singapore (2015 — 2021)
• Principal Investigator A*STAR - Agency for Science, Technology and Research (2015 — 2020)
• Assistant Principal Investigator Agency for Science, Technology, and Research (A*STAR) (2012 — 2014)
• Post Doctoral Fellow The University of British Columbia (2010 — 2012)
• Graduate Student (PhD) The University of British Columbia (2004 — 2010)
• Graduate Student (Masters) McMaster University (2001 — 2003)

Skills

• Neurobiology
• Neuropathology
• Neurodegeneration

Other

Lifesciences, Scientific Writing, Immunology, Genomics, Immunohistochemistry, Life Sciences, Animal Models, Biochemistry, Neuroscience, Genetics, Molecular Biology, Cell Biology

Selected Publications

• Utami KH, Skotte N, Colaço AR, Yusof NABM, Sim B, Yeo XY, Bae HG, Radulescu C, Garcia-Miralles M, Chen Q, Chaldaioupolou G, Liany H, Nama S, Peteri UKA, Sampath P, Castrén ML, Jung S, Mann M, Pouladi MA. Integrative analysis identifies key molecular signatures underlying neurodevelopmental deficits in Fragile X Syndrome. Biological Psychiatry. 2020. 88(6):P500-511. PMID: 32653109.
• Ferrari Bardile C, Garcia-Miralles M, Caron NS, Rayan NA, Langley SR, Harmston N, Rondelli AM, Teo RTY, Waltl S, Anderson LM, Bae HG, Jung S, Williams A, Prabhakar S, Petretto E, Hayden MR, Pouladi MA. Intrinsic mutant HTT-mediated defects in oligodendroglial cells cause myelin deficits and behavioural abnormalities in Huntington disease. Proc. Natl. Acad. Sci. (USA). 2019. 116(19):9622–7. PMID: 31015293.
• Ooi J*, Langley S*, Xu X*, Utami KH*, Sim B, Huang Y, Harmston NP, Tay YL, Ziaei A, Zeng R, Low D, Aminkeng F, Sobota RM, Ginhoux F, Petretto EG, Pouladi MA. Unbiased profiling of isogenic Huntington disease hPSC-derived CNS and peripheral cells reveals strong cell type-specificity of CAG length effects. Cell Reports. 2019. 26(9):2494-2508.e7. PMID: 30811996. * equal contribution.
• Garcia-Miralles M, Geva M, Tan JY, Yusof NA, Cha Y, Kusko R, Tan LJ, Xu X, Grossman I, Orbach A, Hayden MR, Pouladi MA. Early pridopidine treatment improves behavioural and transcriptional deficits in Huntington disease mice. JCI Insight. 2017. 2(23):e95665. PMID: 29212949.
• Xu X, Tay YL, Sim B, Yoon SI, Huang Y, Ooi J, Utami KH, Ziaei A, Ng B, Radulescu C, Ng A, Low D, Loh M, Venkatesh B, Ginhoux F, Augustine GJ, Pouladi MA. Reversal of phenotypic abnormalities by CRISPR/Cas9-mediated gene correction in Huntington disease patient-derived induced pluripotent stem cells. Stem Cell Reports. 2017. 8: 619-633. PMID: 28238795.