Lawrence Zukerberg

Dr. Zukerberg has expertise in gastrointestinal, hematological, and frozen section pathology. He is the Principal Investigator with a research program focused on studying the biology and biochemistry of a novel gene, Cables that interacts with cell cycle control proteins including, CDK2, p53, beta-catenin, mTOR and is a novel cell cycle regulator and tumor suppressor gene. Cables expression is lost in many primary human cancer and it loss can prolong the life of stem cells in some mouse organs. Some of the research projects of Dr. Zukerberg include studying the relationship of Cables to cell cycle control proteins, generating and studying Cables mutant mice, and determining the pathways involved in Cables cell growth regulation. Other recent projects have included identification of cyclin D1 as a marker of mantle cell lymphoma and understanding specific reactive conditions that mimic lymphoma.

Research

We have recently cloned a novel protein, Cables, which maps to human chromosome 18q and inhibits growth of cells in culture and tumor formation in animal models. Our studies will define a novel target for the deletions commonly seen on chromosome 18q. Ultimately, these studies will lay the foundation for new therapeutic approaches.

Clinical Interests:

• Gastrointestinal cancer
• Liver cancer
• Pancreatic cancer

Medical Education

• MD, UMDNJ- Rutgers Medical School
• Residency, Massachusetts General Hospital
• Fellowship, Massachusetts General Hospital
• Fellowship, University of Michigan Hospital

American Board Certifications

• Anatomic Pathology & Clinical Pathology, American Board of Pathology
• Pathology, American Board of Pathology

Publications

• Arnason T, Pino MS, Yilmaz O, Kirley SD, Rueda BR, Chung DC, Zukerberg LR. Cables 1 is a tumor suppressor gene that regulates intestinal tumor progression in Apc (Min) mice. Cancer Biol Ther. 2013. 2013;14:672-678.
• Nazarian RM, Primiani A, Doyle LA, Linskey KR, Duncan LM, Odze RD, Zukerberg LR. Cytokeratin 17: an adjunctive marker of invasion in squamous neoplastic lesions of the anus. American Journal Surgical Pathology 2014;38:78-85.
• Zukerberg L, Mahadevan K, Selig M, Deshpande V. Oesophageal intrasquamous IgG4 deposits: an adjunctive marker to distinguish eosinophilic