Karthik Mallilankaraman

Research Areas of Interest:

• Mitochondrial Calcium and Redox signaling
• Mitochondrial dysfunction in Ischemic Stroke.
• Mitochondrial calcium uniporter in Neurodegenerative and metabolic diseases.
• Mitochondrial targeted pooled RNAi screening.
• Genome-wide RNAi screening in cancer.
• Pathogenesis of Zika virus.

Education

• PhD University of Madras (2002 — 2006)

Selected Publications

• Vais H*, Mallilankaraman K*, Mak D-OD, Hoffman H, Payne R, Tanis JE, and Foskett JK. 2016. EMRE is a Matrix Ca2+ Sensor that Governs Gatekeeping of the Mitochondrial Ca2+ Uniporter. Cell Rep. 14, 403–410. (Preview: Intramitochondrial Ca2+ Sensing by EMRE: The Matrix Outlook on Stimulus-Metabolism Coupling, Mol Cell. 2016 61(5) 646-647)
• Vais H, Tanis JE, Müller M, Payne R, Mallilankaraman K, Foskett JK. 2015. MCUR1, CCDC90A, Is a Regulator of the Mitochondrial Calcium Uniporter. Cell Metab. 22(4):533-535.
• Mallilankaraman K, Doonan PJ, Cárdenas C, Chandramoorthy HC, Muller M, Miller R, Hoffman NE, Gandhirajan RK, Molgó J, Birnbaum M, Rothberg B, Mak D-OD, Foskett JK and Madesh M. 2012. MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca2+ uptake that regulates cell survival. Cell 151:630-644. (Impact Factor 33.12)
• Mallilankaraman K, Cárdenas C, Doonan PJ, Chandramoorthy HC, Irrinki KM, Golenár T, Csordás G, Madireddi P, Yang J, Muller M, Miller R, Kolesar JE, Molgo J, Kaufman B, Hajnoczky G, Foskett JK and Madesh M. 2012. MCUR1 is an Essential Component of Mitochondrial Ca2+ Uptake that Regulates Cellular Metabolism. Nature Cell Biol 14:1336-43. (Impact Factor 20.06) (Research Highlight: Calcium: Helping Ca2+ into mitochondria, Nature Rev Mol Cell Biol. 2012 14(4):4)
• Vagnozzi RJ, Gatto-Jr GR, Kallander LS, Hoffman NE, Mallilankaraman K, Ballard VLT, Lawhorn BG, Stoy P, Philp J, Graves AP, Naito Y, Lepore JJ, Gao E, Madesh M and Force T. 2013. Inhibition of TNNI3K, a cardiomyocyte-specific kinase, limits ischemic injury and left ventricular remodeling in a model of percutaneous coronary intervention. Sci Transl Med. 5; 207ra141. (Impact Factor 14.41)
• Gandhirajan RK, Meng S, Chandramoorthy HC, Mallilankaraman K, Mancarella S, Gao H, Razmpour R, Yang XF, Houser SR, Koch WJ, Chen J, Wang H, Soboloff J, Gill DL and Madesh M. 2013. Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation. J. Clin. Invest. 123(2): 887–902. (Impact Factor 13.77) (Commentary: Calcium flux and endothelial dysfunction during acute lung injury: a STIMulating target for therapy. J. Clin. Invest.2013 123(3): 1015-1018)
• Irrinki KM*, Mallilankaraman K*, Thapa RJ, Chandramoorthy HC, Smith FJ, Jog NR, Gandhirajan RK, Kelsen SG, Houser SR, May MJ, Balachandran S and Madesh M. 2011. Requirement of FADD, NEMO and BAX/BAK for aberrant mitochondrial function in TNFa-induced necrosis. Mol. Cell. Biol. 31:3745-3758. (Impact Factor 5.04)

Awards

• 2013 Young Bioenergeticist Award at 57th Biophysical society meeting, Philadelphia, PA