Johannes Antonius Maria Christiaans

Education

• Doctor of Philosophy - PhD Vrije Universiteit Amsterdam (1989 — 1994)
• MSc Utrecht University (1983 — 1988)
• Hertog Jan College (1975 — 1983)

Companies

• Quality Assurance Manager PharmaSynth AS (2019)
• Visiting Professor, Institute of Chemistry University of Tartu (2019)
• Chief Scientific Officer (CSO) and Qualified Person (QP) PharmaSynth AS (2018)
• Adjunct Assistant Professor (Department of Diagnostic Radiology) National University of Singapore (2015 — 2017)
• Head of Radiopharmaceutical Chemistry & Cyclotron Operations and Qualified Person (QP) CIRC; A*STAR - Agency for Science, Technology and Research (2012 — 2016)
• Senior Scientist Radiochemistry VU University Medical Center (2009 — 2012)
• Group Leader Medicinal Chemistry Mercachem (2007 — 2009)
• Group Leader Medicinal Chemistry Altana Pharma - Nycomed (2000 — 2007)
• Senior Scientist Medicinal Chemistry University of Kuopio (1996 — 2000)

Supervised dissertations

• Klein, PJ, Doctor's Degree, 2019, (sup) Windhorst, AD; van Berckel, BNM; Johannes Antonius Maria Christiaans, Synthesis, radiolabelling and preclinical evaluation of novel NMDA ligands as potential tracers for positron emission tomography, Department of Radiology & Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands..
• Jarho, E, Doctor's Degree, 2007, (sup) Johannes Antonius Maria Christiaans; Gynther, J; Wallén, EAA, Synthesis, Structure-Activity Relationships and Physico-Chemical Properties of Novel Prolyl Oligopeptidase Inhibitors, University of Kuopio (Finland), Faculty of Pharmacy, Department of Pharmaceutical Chemistry.
• Wallen, EAA, Doctor's Degree, 2003, (sup) Johannes Antonius Maria Christiaans; Gynther, J, Design and Synthesis of novel Prolyl Oligopeptidase Inhibitors, University of Kuopio (Finland), Faculty of Pharmacy, Department of Pharmaceutical Chemistry.
• Kovalainen, JT, Doctor's Degree, 2000, (sup) Johannes Antonius Maria Christiaans; Gynther, J, Intramolecular hydrogen bonding in histamine H3-receptor activation: Synthesis, NMR studies and SAR of a series of H3-receptor ligands, University of Kuopio (Finland), Faculty of Pharmacy, Department of Pharmaceutical Chemistry.

Publications

Metaxas, Athanasios; van Berckel, Bart N. M.; Klein, Pieter J.; Verbeek, Joost; Nash, Emily C.; Kooijman, Esther J. M.; Renjaan, Veronique A.; Golla, Sandeep S., V; Boellaard, Ronald; Christiaans, Johannes A. M.; Windhorst, Albert D.; Leysen, Josee E. (2019). Binding characterization of N-(2-chloro-5-thiomethylphenyl)- N '-(3-H-3 methoxy phenyl)-N '-methylguanidine ([H-3]GMOM), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist. Pharmacology Research & Perspectives, 7 (1), UNSP 00458.10.1002/prp2.458.

van der Aart, Jasper; Yaqub, Maqsood; Kooijman Esther; Bakker, Jaco; Langermans, Jan; Schuit, Robert; Hofman, Mark; Christiaans, Johannes; Lammertsma, Adriaan; Windhorst, Albert; van Berckel, Bart (2019). Evaluation of the Novel PET Tracer [11C]HACH242 for Imaging the GluN2B NMDA Receptor in Non-Human Primates. Molecular Imaging and Biology, 21 (4), 676−685. DOI: 10.1007/s11307-018-1284-x.

Klein, Pieter J.; Schuit, Robert C.; Metaxas, Athanasios; Christiaans, Johannes A. M.; Kooijman, Esther; Lammertsma, Adriaan A.; van Berckel, Bart N. M.; Windhorst, Albert D. (2017). Synthesis, radiolabeling and preclinical evaluation of a [C-11]GMOM derivative as PET radiotracer for the ion channel of the N-methyl-D-aspartate receptor. Nuclear Medicine and Biology, 51, 25−32.10.1016/j.nucmedbio.2017.05.003.

Klein, Pieter J.; Chomet, Marion; Metaxas, Athanasios; Christiaans, Johannes A. M.; Kooijman, Esther; Schuit, Robert C.; Lammertsma, Adriaan A.; van Berckel, Bart N. M.; Windhorst, Albert D. (2016). Synthesis, radiolabeling and evaluation of novel amine guanidine derivatives as potential positron emission tomography tracers for the ion channel of the N-methyl-D-aspartate receptor. European Journal of Medicinal Chemistry, 118, 143−160.10.1016/j.ejmech.2016.04.022.

Golla SVS,; Klein, PJ.; Bakker J.; Schuit RC.; Christiaans JAM.; van Geest L.; Kooijman EJM.; Oropeza-Seguias GM.; Langermans JAM.; Leysen JE.; Boellaard R.; Windhorst AD.; van Berckel BNM.; Metaxas A. (2015). Preclinical evaluation of [18F]PK-209, a new PET ligand for imaging the ion-channel site of NMDA receptors. Nuclear Medicine and Biology, 42 (2), 205−212.10.1016/j.nucmedbio.2014.09.006.

Klein, Pieter J.; Christiaans, Johannes A. M.; Metaxas, Athanasios; Schuit, Robert C.; Lammertsma, Adriaan A.; van Berckel, Bart N. M.; Windhorst, Albert D. (2015). Synthesis, structure activity relationship, radiolabeling and preclinical evaluation of high affinity ligands for the ion channel of the N-methyl-D-aspartate receptor as potential imaging probes for positron emission tomography. Bioorganic & Medicinal Chemistry, 23 (5), 1189−1206.10.1016/j.bmc.2014.12.029.

Christiaans, Johannes A. M.; Klein, Pieter J.; Metaxas, Athanasios; Kooijman, Esther J. M.; Schuit, Robert C.; Leysen, Josee E.; Lammertsma, Adriaan A.; van Berckel, Bart N. M.; Windhorst, Albert D. (2014). Synthesis and preclinical evaluation of carbon-11 labelled N-((5-(4-fluoro-2-[C-11]methoxyphenyl) pyridin-3-yl) methyl) cyclopentanamine as a PET tracer for NR2B subunit-containing NMDA receptors. Nuclear Medicine and Biology, 41 (8), 670−680.10.1016/j.nucmedbio.2014.04.131.

Klein, P.; Christiaans, J.; Metaxas, A.; Lammertsma, A.; van Berckel, B.; Windhorst, A. (2012). GMOM analogs for PET imaging of the NMDA receptor: synthesis and evaluation. Journal of Cerebral Blood Flow & Metabolism, 32 (1, 2012), S100. DOI: 10.1038/jcbfm.2012.79.

Metaxas, A.; Nabuurs, R.; Klein, P.; Christiaans, J.; Welling, M.; van der Weerd, L.; Leysen, J.; 1Lammertsma, A.; Windhorst, A.; van Berckel, B. (2012). Overactivation of NMDA receptors in the aged APPswe-PS1dE9 brain, a mouse model of Alzheimer's disease. 8. ScienceDirect, P638. DOI: 10.1016/j.jalz.2012.05.1702.