James Seddon

I am a Reader in Global Child Health at Imperial, a Consultant in Paediatric Infectious Diseases at St. Mary's Hospital in London and an Associate Professor at Stellenbosch University. I divide my time between Cape Town and London. Clinical work includes the care of children with complex infectious diseases and my major area of research is that of children with tuberculosis.

I studied medicine at Corpus Christi College, Cambridge and Imperial College London and have carried out paediatric training in both the UK and Australia. Before clinical academia, I was an infantry officer in the British army, worked as a doctor for Médecins Sans Frontières in Côte d'Ivoire and spent time on an expedition in Patagonia. I undertook my PhD in Cape Town, studying drug-resistant tuberculosis in children, and have gained Diplomas in Tropical Medicine and Paediatric Infectious Diseases. During 2017 I spent six months at the Department of Global Health and Social Medicine in Harvard University on a Fulbright Scholarship evaluating different strategies to combat drug-resistant tuberculosis in children.

Between 2018 and 2022 I was funded through an MRC Clinician Scientist Fellowship to evaluate correlates of risk in children exposed to multidrug-resistant tuberculosis.

Selected Publications

Journal Articles

• Gunasekera K, Seddon J, 2023, Development and validation of treatment-decision algorithms for children evaluated for pulmonary tuberculosis: an individual participant data meta-analysis, The Lancet Child & Adolescent Health, Vol:7, ISSN:2352-4642, Pages:336-346
• Ranasinghe L, Achar J, Groschel M, et al., 2022, The global impact of COVID-19 on childhood tuberculosis: analysis of notification data, The Lancet Global Health, Vol:10, ISSN:2214-109X, Pages:e1774-e1781
• Turkova A, Wills GH, Wobudeya E, et al., 2022, Shorter treatment for non-severe tuberculosis in African and Indian children, New England Journal of Medicine, Vol:386, ISSN:0028-4793, Pages:911-922
• Dodd P, Yuen C, Jayasooriya S, et al., 2021, Quantifying the global number of tuberculosis survivors: a modelling study, Lancet Infectious Diseases, Vol:21, ISSN:1473-3099, Pages:984-992
• Yuen C, Seddon J, Keshavjee S, et al., 2020, Risk-benefit analysis of tuberculosis infection testing for household contact management in high-burden countries: a mathematical modelling study, The Lancet Global Health, Vol:8, ISSN:2214-109X, Pages:e672-e680
• Snow KJ, Cruz AT, Seddon JA, et al., 2020, Adolescent tuberculosis, The Lancet Child & Adolescent Health, Vol:4, ISSN:2352-4642, Pages:68-79
• Seddon J, Whittaker E, Kampmann B, et al., 2019, The evolving research agenda for paediatric tuberculosis infection, Lancet Infectious Diseases, Vol:19, ISSN:1473-3099, Pages:e323-e329
• Dodd P, Yuen C, Becerra M, et al., 2018, The potential impact of household contact management on childhood tuberculosis: a mathematical modelling study, The Lancet Global Health, Vol:6, ISSN:2214-109X, Pages:e1329-e1338
• Dodd P, Yuen C, Sismanidis C, et al., 2017, The global burden of tuberculosis mortality in children: amathematical modelling study, Lancet Global Health, Vol:5, ISSN:2214-109X, Pages:e898-e906
• Dodd P, Sismanidis C, Seddon JA, 2016, The global burden of drug-resistant tuberculosis in children: a mathematical model, Lancet Infectious Diseases, Vol:16, ISSN:1473-3099, Pages:1193-1201
• Dodd PJ, Gardiner E, Coghlan R, et al., 2014, Burden of childhood tuberculosis in 22 high-burden countries: a mathematical modelling study, The Lancet Global Health, Vol:2, ISSN:2214-109X, Pages:e453-e459