George Pelekos

Areas of Research Expertise

• Peri-implant disease
• Agressive periodontitis
• Periodontal regeneration

Article

• Li S, Mai Z, Gu W, Ogbuehi AC, Acharya A, Pelekos G, Ning W, Liu X, Deng Y, Li H, Lethaus B, Savkovic V, Zimmerer R, Ziebolz D, Schmalz G, Wang H, Xiao H, Zhao J. Molecular Subtypes of Oral Squamous Cell Carcinoma Based on Immunosuppression Genes Using a Deep Learning Approach, Frontiers in Cell and Developmental Biology 2021; 9: article no. 687245-article no. 687245 doi:10.3389/fcell.2021.687245
• Li S, Zhou C, Xu Y, Wang Y, Li L, Pelekos G, Ziebolz D, Schmalz G, Qin Z. Similarity and Potential Relation Between Periimplantitis and Rheumatoid Arthritis on Transcriptomic Level: Results of a Bioinformatics Study, Frontiers in Immunology 2021; 12: article no. 702661-article no. 702661 doi:10.3389/fimmu.2021.702661
• Zafiropoulos G, Abuzayeda M, Al-Asfour AA, Qasim S, Pelekos G, Murray C. Tooth-implant connection with fixed partial dentures in partially edentulous arches. A retrospective cohort study over an 11.8 year observation period, Journal of Clinical and Experimental Dentistry 2021; 13: e659-e668 doi:10.4317/jced.58170
• Ning W, Ma Y, Li S, Wang X, Pan H, Wei C, Zhang S, Bai D, Liu X, Deng Y, Acharya A, Pelekos G, Savkovic V, Li H, Gaus S, Haak R, Schmalz G, Ziebolz D, Ma Y, Xu Y. Shared Molecular Mechanisms between Atherosclerosis and Periodontitis by Analyzing the Transcriptomic Alterations of Peripheral Blood Monocytes, Computational and Mathematical Methods in Medicine 2021; 2021: 1498431-1498431 doi:10.1155/2021/1498431
• DENG K, Pelekos G, Jin L, Tonetti MS. Diagnostic accuracy of a point‐of‐care aMMP‐8 test in the discrimination of periodontal health and disease, Journal of Clinical Periodontology 2021; 48(8): 1051-1065 doi:10.1111/jcpe.13485
• DENG K, Pelekos G, Jin L, Tonetti M. Diagnostic accuracy of self‐reported measures of periodontal disease: A clinical validation study using the 2017 case definitions, Journal of Clinical Periodontology 2021; 48(8): 1037-1050 doi:10.1111/jcpe.13484
• Ning W, Acharya A, Sun Z, Ogbuehi AC, Li C, Hua S, Ou Q, Zeng M, Liu X, Deng Y, Haak R, Ziebolz D, Schmalz G, Pelekos G, Wang Y, Hu X. Deep Learning Reveals Key Immunosuppression Genes and Distinct Immunotypes in Periodontitis, Frontiers in Genetics 2021; 12: article no. 648329-article no. 648329 doi:10.3389/fgene.2021.648329
• Ho DKL, Wong JHL, Pelekos G, Deng K, Tonetti MS. Prevalence and morphological characteristics of disto-lingual roots in mandibular first molars: a cone beam CT study with diagnostic and therapeutic implications, Clinical Oral Investigations 2021; 25(6): 4023-4030 doi:10.1007/s00784-020-03733-3
• Nibali L, Sultan D, Arena C, Pelekos G, Lin GH, Tonetti M. Periodontal infrabony defects: Systematic review of healing by defect morphology following regenerative surgery, Journal of Clinical Periodontology 2021; 48(1): 100-113 doi:10.1111/jcpe.13381
• ZHAO D, Khawaja AT, Jin L, Chan KW, Tonetti M, Tang SCW, Pelekos G. Effect of non-surgical periodontal therapy on renal function in chronic kidney disease patients with periodontitis: a systematic review and meta-analysis of interventional studies, Clinical Oral Investigations 2020; 24: 1607-1618 doi:10.1007/s00784-019-03066-w
• HO SN, Acharya A, Sidharthan S, Li KY, Leung WK, McGrath C, Pelekos G. A Systematic Review and Meta-analysis of Clinical, Immunological, and Microbiological Shift in Periodontitis After Nonsurgical Periodontal Therapy With Adjunctive Use of Probiotics, Journal of Evidence Based Dental Practice 2020; 20(1): article no. 101397-article no. 101397 doi:10.1016/j.jebdp.2020.101397
• WANG Y, Liu HN, Zhen Z, Pelekos G, Wu MZ, Chen Y, Tonetti M, Tse HF, Yiu KH, Jin L. A randomized controlled trial of the effects of non‐surgical periodontal therapy on cardiac function assessed by echocardiography in type 2 diabetic patients, Journal of Clinical Periodontology 2020; 47(6): 726-736 doi:10.1111/jcpe.13291
• Pelekos G, Acharya A, Eiji N, Hong G, Leung WK, McGrath C. Effects of adjunctive probiotic L. reuteri lozenges on S/RSD outcomes at molar sites with deep pockets, Journal of Clinical Periodontology 2020; 47(9): 1098-1107 doi:10.1111/jcpe.13329
• FOK MR, Pelekos G, Tonetti MS. Feasibility and needs for simultaneous or staged bone augmentation to place prosthetically guided dental implants after extraction or exfoliation of first molars due to severe periodontitis, Journal of Clinical Periodontology 2020; 47(10): 1237-1247 doi:10.1111/jcpe.13344
• Pelekos G, Tse JMN, Ho D, Tonetti MS. Defect morphology, bone thickness, exposure settings and examiner experience affect the diagnostic accuracy of standardized digital periapical radiographic images but not of cone beam computed tomography in the detection of peri‐implant osseous defects: An in vitro study, Journal of Clinical Periodontology 2019; 46(12): 1294-1302 doi:10.1111/jcpe.13200
• Pelekos G, HO SN, Acharya A, Leung WK, McGrath C. A double‐blind, paralleled‐arm, placebo‐controlled and randomized clinical trial of the effectiveness of probiotics as an adjunct in periodontal care, Journal of Clinical Periodontology 2019; 46(12): 1217-1227 doi:10.1111/jcpe.13191
• Wang Y, Zhen Z, Liu HN, Lai I, Pelekos G, Tse HF, Yiu KH, Jin L. Periodontitis links to exacerbation of myocardial dysfunction in subjects with type 2 diabetes, Journal of Periodontal Research 2019; 54(4): 339-348 doi:10.1111/jre.12634
• Pelekos G, Lu JZ, Ho DKL, Graziani F, Cairo F, Cortellini P, Tonetti MS. Aesthetic assessment after root coverage of multiple adjacent recessions with coronally advanced flap with adjunctive collagen matrix or connective tissue graft: Randomized clinical trial, Journal of Clinical Periodontology 2019; 46(5): 564-571 doi:10.1111/jcpe.13103
• Jagannathan N, Acharya A, Ong F, Li KY, Nibali L, Pelekos G. Disease severity, debridement approach and timing of drug modify outcomes of adjunctive azithromycin in non-surgical management of chronic periodontitis: a multivariate meta-analysis, BMC Oral Health 2019; 19: 65-65 doi:10.1186/s12903-019-0754-0
• ZHAO D, Zhen Z, Pelekos G, Yiu KH, Jin L. Periodontal disease increases the risk for onset of systemic comorbidities in dental hospital attendees: An 18-year retrospective cohort study, Journal of Periodontology 2019; 90: 225-233 doi:10.1002/JPER.18-0224
• Gupta B, Acharya A, Singh S, Brazolli S, Ghorab M, Malik S, Pelekos G, Rossouw PE. Evaluation of jawbone morphology and bone density indices in panoramic radiographs of selective serotonin reuptake inhibitor users: a preliminary study, Dentomaxillofacial Radiology 2019; 48(1): article no. 20170360-article no. 20170360 doi:10.1259/dmfr.20170360
• Chan YH, Pelekos G, Ho KL, Cortellini P, Tonetti M. The depth of the implant mucosal tunnel modifies the development and resolution of experimental peri-implant mucositis: A case-control study, Journal of Clinical Periodontology 2019; 46: 248-255 doi:10.1111/jcpe.13066
• Acharya A, Li S, Liu X, Pelekos G, Ziebolz D, Mattheos N. Biological links in Periodontitis and Rheumatoid arthritis: discovery via text-mining PubMed abstracts, Journal of Periodontal Research 2019; 54(4): 318-328 doi:10.1111/jre.12632
• Kaiser F, Donos N, Henderson B, Alagarswamy R, Pelekos G, Boniface D, Nibali L. Association between circulating levels of heat-shock protein 27 and aggressive periodontitis, Cell Stress and Chaperones 2018; 23: 847-856 doi:10.1007/s12192-018-0891-4
• ZHAO D, Khawaja AT, Jin L, Li KY, Tonetti M, Pelekos G. The directional and non-directional associations of periodontitis with chronic kidney disease: A systematic review and meta-analysis of observational studies, Journal of Periodontal Research 2018; 53(5): 682-704 doi:10.1111/jre.12565
• Pelekos G, Acharya A, Tonetti M, Bornstein MM. Diagnostic performance of cone beam computed tomography in assessing peri-implant bone loss: A systematic review, Clinical Oral Implants Research 2018; 29(5): 443-464 doi:10.1111/clr.13143
• WANG Y, Liu HN, Zhen Z, Yiu KH, Tse HF, Pelekos G, Tonetti M, Jin L. Periodontal treatment modulates gene expression of endothelial progenitor cells in diabetic patients, Journal of Clinical Periodontology 2017; 44: 1253-1263 doi:10.1111/jcpe.12806
• Gupta B, ACHARYA A, Pelekos G, Gopalakrishnan D, Kolokythas A. Selective serotonin reuptake inhibitors and dental implant failure-A significant concern in elders?, Gerodontology 2017; 34(4): 505-507 doi:10.1111/ger.12287
• Liu F, Pelekos G, Jin LJ. The gingival biotype in a cohort of Chinese subjects with and without history of periodontal disease, Journal of Periodontal Research 2017; 52(6): 1004-1010 doi:10.1111/jre.12471
• Pelekos G, Mardas N. Natural teeth or implants? Informing the decision-making process, Implant Practice US 2015; 8(3): 38-40
• Nibali L, Rizzo M, Li Volti G, D'Aiuto F, Giglio RV, Barbagallo I, Pelekos G, Donos L. Lipid subclasses profiles and oxidative stress in aggressive periodontitis before and after treatment, Journal of Periodontal Research 2015; 50: 890-896 doi:10.1111/jre.12283
• Nibali L, Pelekos G, Onabolu O, Donos N. Effect and timing of non-surgical treatment prior to periodontal regeneration: a systematic review, Clinical Oral Investigations 2015; 19: 1755-1761 doi:10.1007/s00784-015-1493-5
• Pelekos G. Non-surgical treatment in periodontal treatment in modern periodontoogy. Is periodontal surgery still important?, Hong Kong Dental Association Newsletter 2015; 12-15
• Nibali L, Pelekos G, D'Aiuto F, Chaudhary N, Habeeb R, Ready D, Parkar M, Donos N. Influence of IL-6 haplotypes on clinical and inflammatory response in aggressive periodontitis, Clinical Oral Investigations 2013; 17(4): 1235-1242 doi:10.1007/s00784-012-0804-3

Conference Paper

• Li GH, Hsung TC, Ling WK, Lam YHW, Pelekos G, McGrath C. Automatic Site-Specific Multiple Level Gum Disease Detection Based on Deep Neural Network, 2021 15th International Symposium on Medical Information and Communication Technology (ISMICT) 2021; 201-205 doi:10.1109/ISMICT51748.2021.9434936
• Deng K, Pelekos G, Jin L, Tonetti M. Bleeding on brushing and slurry hemoglobin for identifying periodontal health/diseases, Journal of Dental Research (Spec Issue) 2021; 100(Spec Iss A): presentation ID 1729-presentation ID 1729
• Zhao D, Yiu KH, Wu M, Yu SY, Pelekos G, Jin L. Is severe periodontitis a pre-indicator of abnormal systemic conditions?, Journal of Dental Research (Spec Issue) 2019; 98(Spec Iss A): abstract no. 0361-abstract no. 0361
• Zhao D, Yiu KH, Zhen Z, Pelekos G, Tonetti M, Jin L. Oral/periodontal conditions are closely associated with general health status and comorbidity profiles, Journal of Clinical Periodontology 2018; 45(S19): 87 Abstract no. PD128-87 Abstract no. PD128 doi:10.1111/jcpe.130_12914
• Wang Y, Liu H, Zhen Z, Yiu KH, Tse HF, Zhang C, Pelekos G, Jin LJ. Periodontal treatment increases circulating EPC counts in patients with T2DM, IADR/PER 96th General Session & Exhibition 2018; Final Presentation ID: 1114-Final Presentation ID: 1114
• Wang Y, Liu HN, Zhen Z, Yiu KH, Tse HF, Zhang C, Pelekos G, Jin L. Periodontal treatment increases circulating EPC counts in patients with T2DM, Journal of Dental Research (Spec Issue) 2018; 97(Spec Iss B): no. 1114-no. 1114
• Zhao D, Luo W, Pelekos G, Jin L. Kidney infection pathogen/P. gingivalis lipopolysaccharides modulate pro-inflammatory response in hRPTEpiCs, Journal of Dental Research (Spec Issue) 2018; 97(Spec Iss B): abstract no. 3492-abstract no. 3492
• Wang Y, Zhen Z, Liu HN, Lai IA, Pelekos G, Tse HF, Yiu KH, Jin L. A case‐control study on periodontitis and left ventricular function in patients with diabetes, Journal of Clinical Periodontology 2018; 45(S19): 98 Abstract no. PD156-98 Abstract no. PD156 doi:10.1111/jcpe.160_12914
• Nibali L, Kaiser F, Alagarswami R, Henderson B, Pelekos G, Donos N. Differential circulating levels of HSP-27 in chronic and aggressive periodontitis, Journal of Dental Research (Spec Issue) 2017; 96(Spec Iss A): no. 1748-no. 1748
• Zhao D, Yiu KH, Zhen Z, Pelekos G, Jin L. Periodontitis is linked to noncommunicable diseases among dental hospital attendees, Journal of Dental Research (Spec Issue) 2017; 96(Spec Iss A): abstract no. 0963-abstract no. 0963
• Liu F, Pelekos G, Jin L. The gingival biotype in a cohort of Chinese subjects with and without history of periodontal disease, Journal of Dental Research (Spec Issue) 2017; 96(Spec Iss A): no. 3480-no. 3480
• Wang Y, Liu HN, Zhen Z, Yiu KH, Pelekos G, Tse HF, Jin L. Periodontal treatment affects gene expression of EPCs in DM patients, Journal of Dental Research (Spec Issue) 2017; 96(Spec Iss A): abstract no. 2195-abstract no. 2195
• Wang Y, Liu HN, Zhen Z, Yiu KH, Tse HF, Pelekos G, Jin L. Decreased CPC/EPC counts in type 2 diabetes patients with periodontitis, Journal of Dental Research 2017; 96(Spec Iss B): 153-153
• Zhao D, Yiu KH, Zhen Z, Pelekos G, Jin L. Deterioration of periodontal conditions reflects individual susceptibility to systemic comorbidities?, Journal of Dental Research 2017; 96(Spec B): 191-191
• Wang Y, Liu HHL, Zhen Z, Yiu KH, Tse HF, Pelekos G, Jin L. Periodontitis links with EPC counts in patients with T2 diabetes, Journal of Dental Research 2016; 95(Spec. Iss. B)
• Chang JWW, Pelekos G, Pow EHN. Clinical challenges and solutions, Hong Kong International Dental Expo and Symposium, 2015 2015;
• Cheng CK, Jin LJ, Pelekos G. Halitosis and oral/periodontal conditions in Hong Kong adults, Journal of Dental Research 2015; 94(Spec Iss B (SEA Division))
• Eng HL, Pelekos G. Effects of pregnancy on aggressive periodontitis disease progression, Journal of Dental Research 2015; 94(Spec Iss B (SEA Division))
• Nibali L, Rizzo M, Livolti GL, D'Aiuto F, Pelekos G, Donos N. Lipid subclasses profiles and oxidative stress in aggressive periodontitis before and after treatment, Journal of Dental Research Meeting Abstracts 2015; 94(Spec. Iss. A)
• Pelekos G, Nibali L, Donos N, Onabolu L. Non-surgical treatment in periodontal regeneration studies: a systematic review, Journal of Dental Research 2014; 93(Spec. Iss. C)