Cho Yeow Koh

His research mainly focuses on the discovery and characterization of novel proteins and peptides (toxins) from natural sources such as haematophagous and venomous animals, with a constant emphasis on the development of therapeutics and medical technologies, especially in the field of cardiovascular and neglected tropical diseases.

RESEARCH AREAS

Cardiovascular Diseases : Cellular and Molecular Mechanisms, Others: Drug/probe discovery and development, Therapy

RESEARCH INTEREST(S)

• Structure-function relationships
• Drug/probe discovery
• Venom
• Salivary proteins
• X-ray crystallography

RECENT PUBLICATIONS

• Raskar T, Koh CY, Niebling S, Kini RM, Hosur MV. 2019 Feb. X-ray crystallographic analysis of time-dependent binding of guanidine hydrochloride to HEWL: First steps during protein unfolding. Int J Biol Macromol. 122:903-913. doi: 10.1016/j.ijbiomac.
• Latinović Z, Leonardi A, Kovačič L, Koh CY, Šribar J, Bakija AT, Venkateswarlu D, Kini RM, Križaj I. 2018 Oct. The First Intrinsic Tenase Complex Inhibitor with Serine Protease Structure Offers a New Perspective in Anticoagulant Therapy. Thromb Haemost. 118:1713-1728. doi: 10.1055/s-0038-1669785.
• Barros-Álvarez X, Kerchner KM, Koh CY, Turley S, Pardon E, Steyaert J, Ranade RM, Gillespie JR, Zhang Z, Verlinde CLMJ, Fan E, Buckner FS, Hol WGJ. 2017 Jul. Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts. Biochimie. 138:124-136. doi: 10.1016/j.biochi.2017.04.006.
• Iyer JK, Koh CY, Kazimirova M, Roller L, Jobichen C, Swaminathan K, Mizuguchi J, Iwanaga S, Nuttall PA, Chan MY, Kini RM. 2017 Jul. Avathrin: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid tick, Amblyomma variegatum. FASEB J. 31:2981-2995. doi: 10.1096/fj.201601216R.
• Huang W, Zhang Z, Barros-Álvarez X, Koh CY, Ranade RM, Gillespie JR, Creason SA, Shibata S, Verlinde CLMJ, Hol WGJ, Buckner FS, Fan E. 2016 Nov. Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors. Eur J Med Chem. 124:1081-1092. doi: 10.1016/j.ejmech.2016.10.024.

Companies

• Research Assistant Professor National University of Singapore (2018)
• Senior Research Fellow National University of Singapore (2014 — 2017)
• Senior Fellow University of Washington (2010 — 2014)
• Research Assistant National University of Singapore (2009 — 2009)
• PHD Candidate National University of Singapore (2004 — 2009)

Education

• Doctor of Philosophy (Ph.D.) National University of Singapore (2004 — 2009)
• Bachelor of Science (BS) National University of Singapore (2000 — 2004)