Carlos Fernandez-del Castillo

Dr. Carlos Fernandez-del Castillo is a gastrointestinal surgeon specialized in pancreatic and biliary diseases.

Dr. Fernandez-del Castillo is the director of the pancreas and biliary surgery program and clinical co-director of the GI cancer center at the MGH, as well as professor of surgery at Harvard Medical School. He is a widely recognized expert in pancreatic and biliary surgery, and has authored over 350 publications on pancreatic cancer, cystic tumors of the pancreas, Intraductal papillary mucinous neoplasms (IPMN), neuroendocrine pancreatic tumors, acute and chronic pancreatitis. For several years he has performed the largest number of pancreatic resections in New England. He serves in the editorial board many journals, including Annals of Surgery and Pancreatology, and is a past president of the American Pancreatic Association.

Clinical Interests

• Pancreatic disease
• Pancreatobiliary surgery
• Gastrointestinal surgery
• Pancreatic cancer
• Pancreatic cystic tumors
• Pancreatitis (acute and chronic)
• Pancreatic and hepatobiliary surgery

Medical Education

• MD, Universidad Autonoma De Mexico
• Residency, Instituto Nacional de la Nutricion
• Fellowship, Massachusetts General Hospital

Research & Publications

Research Summary

Dr. Fernandez-del Castillo has laboratory and clinical research focused on pathogenesis of acute pancreatitis, models of pancreatic cancer, molecular genetics of pancreatic cancer and cystic neoplasms of the pancreas, and neuroendocrine tumors.

Publications

Select Publications:

• Phase I Study of Preoperative Short-Course Chemoradiation with Proton Beam Therapy and Capecitabine for Resectable Pancreatic Ductal Adenocarcinoma of the Head. Hong TS, Ryan DP, Blaszkowsky LS, Mamon HJ, Kwak EL, Mino-Kenudson M, Adams J, Yeap B, Winrich B, Delaney TF, Fernandez-Del Castillo C. Int J Radiat Oncol Biol Phys. 2010 Apr 24.
• Invasive intraductal papillary mucinous carcinomas of the pancreas: predictors of survival and the role of lymph node ratio. Partelli S, Fernandez-Del Castillo C, Bassi C, Mantovani W, Thayer SP, Crippa S, Ferrone CR, Falconi M, Pederzoli P, Warshaw AL, Salvia R. Ann Surg. 2010 Mar;251(3):477-82.
• New metastatic lymph node ratio system reduces stage migration in patients undergoing D1 lymphadenectomy for gastric adenocarcinoma. Maduekwe UN, Lauwers GY, Fernandez-Del-Castillo C, Berger DL, Ferguson CM, Rattner DW, Yoon SS. Ann Surg Oncol. 2010 May;17(5):1267-77. Epub 2010 Jan 23.
• Pancreatic cysts: preoperative diagnosis and clinical management. Pitman MB, Lewandrowski K, Shen J, Sahani D, Brugge W, Fernandez-del Castillo C. Cancer Cytopathol. 2010 Feb 25;118(1):1-13. Review.
• Pancreatic duct glands are distinct ductal compartments that react to chronic injury and mediate Shh-induced metaplasia. Strobel O, Rosow DE, Rakhlin EY, Lauwers GY, Trainor AG, Alsina J, Fernández-Del Castillo C, Warshaw AL, Thayer SP. Gastroenterology. 2010 Mar;138(3):1166-77. Epub 2009 Dec 21.