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Ari Koskinen

Professor, organic chemistry at Aalto University School of Business

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  • Aalto University School of Business

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Biography

Aalto University School of Business

My research has started from development of new synthetic methodology. The new methods have been successfully applied to e.g. total syntheses of several natural products (e.g. jaspine B, nojirimycin analogues, amaminol, sphingolipids), as well as short and efficient syntheses of active pharmaceutical agents (e.g. pregabalin). These syntheses necessitated in-depth investigations in the underlying mechanisms and theory of the reactions involved. This deeper understanding again allowed us to invent powerful green technologies such as: Cu-catalyzed air-oxidation of alcohols; Cu-mediated hydrosilylations of unsaturated carbonyl compounds, (organo)catalytic conjugate additions. and the first organocatalytic IMDA in 2005. The underlying theme in all these methodology/small molecule investigations has been a long term goal to achieve practical syntheses of complex organic molecules to interrogate the biological systems. I have chosen two major important targets: cellular control of the cell cycle through the action of the protein phosphorylation mechanisms (calyculins through protein phosphatases), and sequence selective recognition of DNA stretches with synthetic structurally defined man-designed probe molecules. BACKGROUND

I have been highly motivated from early stages of my academic development: I was among the youngest ever PhD's in Finland and at the age of 26 (including one year of industrial experience and one year of military service), I was the youngest chemistry doctoral candidate of Helsinki University of Technology. I then decided to look for the best possible further education I could obtain, and moved to the University of California, Berkeley, to do a two year post-doc with Professor Henry Rapoport, an eminent pioneer in asymmetric synthesis of natural products. In 1985 I returned to Finland for a two year project in the pharmaceutical industry (Orion Corporation – Fermion). My task was to initiate a new drug development group, an industrial R&D function then in its infancy in Finland, which led me to learn more of drug development and computer aided drug design: my group was among the pioneers to implement chemical database management systems (then MDL) and molecular modeling (Clark Still's MacroModel) into routine daily work of a synthetic medicinal chemist. We also actively worked to develop computerized methods, and one member of my group spent half a year in the research group of Professor Corwin Hansch, a pioneer in QSAR. The student eventually became the first one in Scandinavia to defend his thesis on 3D QSAR methods. During this time I was also trained as a group leader and my responsibility was to direct a group of 10-15 people of varied academic backgrounds. After the two years in industry, I decided to move back to academia, and upon the encouragement of Professor Rapoport, I returned to California in 1987. Looking for academic jobs both in the States and Europe at the end of the 80's was very frustrating, and after frozen offers from MIT (Department of Applied Biological Sciences, which was closed) and University of Arizona, Tucson, I landed on my first independent academic job as a lecturer at the University of Surrey in 1989. In 1991 I had the opportunity to return to Finland, as a full professor at the University of Oulu. After Oulu, at the turn of the millennium, I was a co-founder of a small company, and acted as the CEO and CSO for a combined period of nearly two years before taking up the full time responsibilities at my alma mater, Helsinki University of Technology, now Aalto University, in 2000 as the Professor of Organic Chemistry.

CURRICULUM VITAE

Personal data:

Date of Birth: 22 September, 1956

Place of Birth: Hyvinkää, Finland

Marital Status: married to Dr. Päivi Koskinen, 5 children: Tiina –86, Joanna –89, Heidi –90, Sara –94, Mikko –02.

Professional data:

Current position: Aalto University School of Chemical Technology, Department of Chemistry, Professor of Organic Chemistry, 1/2011 -

                               Docent in Organic Chemistry, University of Helsinki, 10/1987 -

                               Docent in Organic Chemistry, University of Turku, 11/2001-

Education:

Doctor of Technology, Helsinki University of Technology, Espoo, Finland 22.8.1983.

                               Licentiate in Technology, HUT, Espoo, Finland 20.4.1982.

                               Master of Science in Technology, HUT, Espoo, Finland 6.2.1979.

                               Matriculation Examination, Hyvinkää High School 31.5.1975.

Previous Professional Experience:

                               Helsinki University of Technology, Department of Chemical Technology, Professor of Organic Chemistry, 8/1999 – 12/2010.

                               Guest Professor of Chemistry, Hebei University, China, 2005-2009.

                               University of Oulu, Department of Chemistry; Professor of Organic Chemistry, 9/91 - 7/99.

                               Primco Ltd., CEO/CSO (part-time), 6/98 – 12/2000.

                               Neste Corporation, Consultant for Corporate Technology, 5/96 – 4/98.

                               University of Surrey, Guildford, Surrey, UK; Lecturer, 4/89 - 8/91.

                               KSV Lipids, Helsinki; senior scientist, 1-3/89.

                               University of California, Berkeley; visiting senior scientist (supervisor: professor Henry Rapoport), 7/1987-12/1988.

                               Orion-Corp Ltd - Fermion, Espoo; project manager, 5/1985-7/1987.

                               University of California, Berkeley; visiting post-doctoral chemist (supervisor: professor Henry Rapoport), 8/1983-4/1985.

                               Helsinki University of Technology, Espoo; Assistant in organic chemistry, 8/82 - 5/85. (Leave of absence: 1.9.1983 - 30.4.1985)

                               Academy of Finland; research associate, 1/81 - 7/82.

                               Medipolar Oy; research associate, 1/79 - 12/79.

Academic credits (abbreviated):

University appointed Inspector or Opponent

  •   in Sweden (KTH, SU)        4 times

  •   in Norway (Bergen)           3 times

  •   in Finland                            8 times

  •   in Estonia (Tallinn)  1 time

Appointed referee for professorship

  •   in Finland                            5 times

  •   in Sweden                         3 times

  •   in Estonia                           1 time

  •   in Greece                           1 time

  •   in USA                                2 times

  •   in Norway                          1 time

  •   in the U.K.                          1 time

Supervised investigations fulfilling the requirements of

  •   Ph.D. (Chemistry)               27 times

  •   M. Sc. (Chemistry)             90 times

  •   B.Sc. (Chemistry)                4 times

                           Ph.D. students at the moment 8

                            Supervised post doctoral associates: 36

Altogether I have supervised 90 (36 during the past 10 years) Master of Science theses, 27 (15) PhD theses and 36 (16) post-doctoral fellows. Of my past collaborators, 9 have initiated successful academic careers:

Michael Krische, Professor at University of Texas, Austin

Petri Pihko, Professor at University of Jyväskylä, Finland

Mehran Ghiaci, Professor at Isfahan University of Technology, Iran

Luis Muñoz, Professor at Universita di Vigo, Spain

Zhi-Qiang Xia, Professor at Washington State University

Michael Edmonds, Professor at Christchurch Polytechnic Institute, New Zealand

Thierry Gefflaut, Professor at Universite Blaise Pascal Clermont, France

Juho Helaja, lecturer at University of Helsinki, Finland

Alan Stewart, lecturer at Bristol University, U.K.

Awards and Titles:

Orion Corporation Research Foundation, 1983

                               Finnish Cultural Foundation, 1983

                               Emil Aaltonen Foundation, 1983

                               CChem, MRSC, 1989

                               Nuffield Foundation Young Investigator Award, 1990

                               Burgenstock Conference on Stereochemistry, award from Finnish Academy of Sciences, 1992

                               Japan Society for the Promotion of Science Invitation Fellowship, 1995

                               DuPont European Research Award, 2001

                               Holger Erdtman Lecturer, KTH, Sweden, 2001

                               Finnish Academy of Science and Letters, member, 2003

Grants:

Nuffield Foundation, UK; Academic (Finnish Academy), Industry co-sponsored (TEKES) and Industrial grants from Finland since 1989.

Evaluator for grant applications for:

                               Science and Engineering Research Council (U.K.), 1990–1992

                               Finnish Academy of Sciences, 1995–

                               Estonian Academy of Sciences, 1999–

                               Norwegian Academy of Science and Technology, 2000–

                               Netherlands organization for scientific research (NWO), 2000

                               Swedish Research Council, 2004, 2008

                               Hungarian Academy of Sciences, 2008

                               Lithuanian State Science and Studies Foundation, 2009

                               Finnish Cultural Foundation, 2001–

                                Invited Evaluator of Estonian Research Institutions (Organic Chemistry), Estonian Higher Education Centre, January 2001.

                               Invited Evaluator of Strategic Networks, NSERC Canada 2007.

                               AstraZeneca Swedish Postdoc Program, 2010.

Editorial board:

Kemia – Kemi 2002–05

                               QSAR & Combinatorial Science 2002–05

                               Chemical Society Reviews, International Advisory Board, 2004–

                               Arkivoc, 2008–

Memberships:

Finnish Chemical Society, 1978-

                               American Chemical Society, 1983-

                               American Association for the Advancement of Science, 1984-

                               Royal Society of Chemistry, 1989-

                               Division of Synthetic Chemistry, Finnish Chemical Soc., founding member, 14.5.1992-

                               European Chemical Society, founding member, 26.11.1994-

                               European Society for Combinatorial Sciences, founding member 1999-

Representations:

EU COST action CM0804 management committee, vice-president, 2009-

                               Member of the University and departmental teaching evaluation and development task force for the implementation of the new degree curriculum, Helsinki University of Technology, 2003–2006.

                               European Association of Chemical and Molecular Sciences (EUCHEM) Organic Chemistry Division, Committee member 2007–

                               Novartis Foundation, Scientific Advisory Panel, 2004–

                               EU COST action D28 management committee, vice-president, 2002-6; President 2006–07.

                               National Representative of IUPAC Organic and Biomolecular Chemistry Division, 2002–

                               National Representative of IUPAC Medicinal Chemistry Section Committee, 1998–2001.

                               Member of Biocenter Oulu Management Committee, 1995-1999.

                               EU COST D2-action Management Committee, 1995–1998.

                               Member of the Scientific Advisory Board, Chemical Industry Federation, Finland, 1993–2002.

                               Member and chairperson of departmental and faculty teaching evaluation and development committees, University of Oulu, 1993–1996.

                               Group Co-ordinator, Synthetic and Mechanistic Chemistry Research Group, University of Surrey, Guildford, 1990–1991.

Referee for scientific publications 1990–:

                               The Journal of Organic Chemistry, Organic Letters, New Journal of Chemistry, Journal of the Chemical Society, Tetrahedron, Tetrahedron:Asymmetry, Tetrahedron Letters, Synlett, Collection of Czechoslovak Chemical Communications, Journal of Organometallic Chemistry, Brazilian Journal of Chemistry, Arkivoc

Activities in Professional Societies:

                               Chairman of the Organising Committee, ESF-COST High-Level Research Conference: Natural Products Chemistry, Biology and Medicine IV, Hotel Villa del Mare, Acquafredda di Maratea, Italy, 28 August – 2 September 2011.

                               Chairman of the Organising Committee, Komppa Centenary Symposium, Espoo, 2003.

                               European Society for Combinatorial Sciences, management committee, 1999–.

                               European Chemical Society, management committee (secretary) 1994–.

                               The first chairperson of the Division of Synthetic Chemistry, Finnish Chemical Society, 14.5.1992.

                               Member of the International Organising Committee for the 1st European Symposium of the European Chemical Society Organic Division, Louvain-la-Neuve, Belgium, Aug. 12–17, 1995.

                               Chairman of the Organising Committee, 1st Symposium on Synthetic Chemistry, Oulu, Finland, 1993; 4th Spring Symposium on Synthetic Chemistry, Espoo, 2000; 14th Spring Symposium on Synthetic Chemistry, Espoo, 2013.

                               Northern Finland’s Chemists’ Association: member of the board (1992-1994), vice-chairman (1992), chairman (1994).

                               Chairman of the Organising Committee, Symposium on Synthetic Organic Chemistry, Finnish Chemical Society Annual Meeting, 1986, 1993, 1997.

Major research interests:

                               Development of novel synthetic methods capable of being transferred into (industrially) applicable synthetic technologies and construction of complex natural and non-natural compounds with multiple chiral centers in enantiopure form. Application of modern asymmetric synthesis to chemical biology and chemical genetics.

Listed in:

Marquis Who's Who in the World (11th Ed to present).

                               Marquis Who's Who in Science and Engineering (2nd Ed to present).

                               Dictionary of International Biography, vol. XXIII.

                               International Who’s Who of Contemporary Achievement (3rd Ed) 1995.

                               Kuka Kukin on (Who is Who in Finland), WSOY, Finland, 1998 –

Hobbies: literature, music, sports (tennis, cycling)

Peer-reviewed scientific articles

Journal article-refereed, Original research

Palladium Catalyzed Direct C-H Arylation of Dicyanobenzenes

Ihanainen, N.E.; Kumpulainen, E.T.T.; Koskinen, A.M.P.
2015 in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (Wiley-Blackwell)
ISSN: 1434-193X

Synthesis of chiral 2-indolyl methanamines and insight into the stereochemistry protecting effects of the 9-phenyl-9-fluorenyl protecting group

Lood, C.S.; Laine, A.E.; Högnäsbacka, A.; Nieger, M.; Koskinen, A.M.P
2015 in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (Wiley-Blackwell)
ISSN: 1434-193X

Enantiospecific Gram Scale Synthesis of (S)-Eleagnine

Lood, C.S.; Nieger, M.; Koskinen, A.M.P.
2015 in TETRAHEDRON (PERGAMON-ELSEVIER SCIENCE LTD)
ISSN: 0040-4020

Versatile Synthesis of Symmetrical Carbazole Based Ligand Precursors via Regioselective Aromatic Bromination

Rembiak, A.; Koskinen, A.M.P.
2015 in SYNTHESIS: STUTTGART (GEORG THIEME VERLAG KG)
ISSN: 0039-7881

Upgrading fast pyrolysis bio-oil quality by esterification and azeotropic water removal

Sundqvist, T.; Oasmaa, A.; Koskinen, Ari
2015 in ENERGY AND FUELS (American Chemical Society)
ISSN: 0887-0624

Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP

van Adrichem, Arjan J.; Fagerholm, Annika; Turunen, Laura; Lehto, Anna; Saarela, Jani; Koskinen, Ari; Repasky, Gretchen A.; Wennerberg, Krister
2015 in COMBINATORIAL CHEMISTRY AND HIGH THROUGHPUT SCREENING (Bentham Science Publishers B.V.)
ISSN: 1386-2073

Concise, stereodivergent and highly stereoselective synthesis of cis- and trans-2-substituted 3-hydroxy-piperidines - development of a phosphite-driven cyclodehydration

Huy, Peter H.; Westphal, Julia C.; Koskinen, Ari M.P.
2014 in BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (Beilstein-Institut Zur Forderung der Chemischen Wissenschaften)

Scalable synthesis of (-)-trans-3-hydroxypipecolic acid via a useful chiral building block

Karjalainen, Oskari K.; Koskinen, Ari M.P.
2014 in TETRAHEDRON (PERGAMON-ELSEVIER SCIENCE LTD)
ISSN: 0040-4020

Boron Enolate Chemistry toward the Syntheses of Polyketide Stereotetrads

Koskinen, Ari M.P.
2014 in CHEMICAL RECORD (John Wiley and Sons Inc.)
ISSN: 1527-8999

Synthesis of ( S)-and ( R)- Harmicine from Proline: An Approach Toward Tetrahydro- beta- carbolines

Lood, Christopher S.; Koskinen, Ari M.P.
2014 in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (Wiley-Blackwell)
ISSN: 1434-193X

Efficient, Stereodivergent Access to 3-Piperidinols by Traceless P(OEt)3 Cyclodehydration

Huy, Peter; Koskinen, Ari
2013 in ORGANIC LETTERS (AMER CHEMICAL SOC)
ISSN: 1523-7060

Diastereoselective Intramolecular Allyl Transfer from Allyl Carbamate Accompanied by 5-endo-trig Ring Closure

Karjalainen, Oskari K.; Nieger, Martin; Koskinen, Ari M.P.
2013 in ANGEWANDTE CHEMIE (Wiley-VCH Verlag GmbH & Co. KGaA)
ISSN: 1433-7851

Garner’s aldehyde as a versatile intermediate in the synthesis of enantiopure natural products

Passiniemi, Mikko; Koskinen, Ari
2013 in BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (Beilstein-Institut Zur Forderung der Chemischen Wissenschaften)

Stereocontrolled construction of decahydro quinoline ring systems: the case of lepadin alkaloids (Review)

Pelss, Andrejs.; Koskinen, Ari M.P.
2013 in CHEMISTRY OF HETEROCYCLIC COMPOUNDS (Springer New York)
ISSN: 0009-3122

Diastereoselective Synthesis of Vicinal Amino Alcohols

Karjalainen, Oskari; Koskinen, Ari
2012 in ORGANIC AND BIOMOLECULAR CHEMISTRY (ROYAL SOC CHEMISTRY)
ISSN: 1477-0520

Rapid and practical synthesis of (-)-1-deoxyaltronojirimycin

Karjalainen, Oskari K.; Koskinen, Ari M.P.
2011 in ORGANIC AND BIOMOLECULAR CHEMISTRY (ROYAL SOC CHEMISTRY)
ISSN: 1477-0520

Chirospecific synthesis: Catalysis and chiral pool hand in hand

Koskinen, Ari M.P.
2011 in PURE AND APPLIED CHEMISTRY (BLACKWELL SCIENCE LTD)
ISSN: 0033-4545

Enantioselective synthesis of norfuranomycins

Passiniemi, Mikko; Koskinen, Ari M.P.
2011 in Tetrahedron Letters (PERGAMON-ELSEVIER SCIENCE LTD)
ISSN: 0040-4039

Enantioselective synthesis of Boc-protected norfuranomycins

Passiniemi, Mikko; Koskinen, Ari M. P.
2011 in Tetrahedron Letters (PERGAMON-ELSEVIER SCIENCE LTD)
ISSN: 0040-4039

Asymmetric synthesis of Pachastrissamine (Jaspine B) and its diastereomers via ?3-allylpalladium intermediates

Passiniemi, Mikko; Koskinen, Ari M.P.
2011 in ORGANIC AND BIOMOLECULAR CHEMISTRY (ROYAL SOC CHEMISTRY)
ISSN: 1477-0520

Demethylation of Aromatic Methyl Ethers Using Ionic Liquids under Microwave Irradiation

Passiniemi, Mikko; Myllymaki, Mikko J.; Vuokko, Juha; Koskinen, Ari M.P.
2011 in LETTERS IN ORGANIC CHEMISTRY (Bentham Science Publishers B.V.)
ISSN: 1570-1786

Calyculins and Related Marine Natural Products as Serine-Threonine Protein Phosphatase PP1 and PP2A Inhibitors and Total Syntheses of Calyculin A, B, and C

Fagerholm, Annika E.; Habrant, Damien; Koskinen, Ari M.P.
2010 in MARINE DRUGS (Bentham Science Publishers B.V.)

Conversion of carbonyl compounds to alkynes: general overview and recent developments

Habrant, Damien; Rauhala, Vesa; Koskinen, Ari M.P.
2010 in CHEMICAL SOCIETY REVIEWS (Royal Society of Chemistry)
ISSN: 0306-0012

Towards the total synthesis of calyculin C: Preparation of the C9-C25 spiroketal-dipropionate unit

Habrant, Damien; Koskinen, Ari M.P.
2010 in ORGANIC AND BIOMOLECULAR CHEMISTRY (ROYAL SOC CHEMISTRY)
ISSN: 1477-0520

Short and Straightforward Synthesis of (-)-1-Deoxygalactonojirimycin

Karjalainen, Oskari K.; Passiniemi, Mikko; Koskinen, Ari M.P.
2010 in ORGANIC LETTERS (AMER CHEMICAL SOC)
ISSN: 1523-7060

The 9-Phenyl-9-fluorenyl Group for Nitrogen Protection in Enantiospecific Synthesis

Karppanen, Essi J.; Koskinen, Ari M.P.
2010 in MOLECULES (AMER CHEMICAL SOC)

3-Heterocycle-Phenyl N-Alkylcarbamates as FAAH Inhibitors: Design, Synthesis and 3D-QSAR Studies

Kasnanen, Heikki; Myllymaki, Mikko J.; Minkkila, Anna; Kataja, Antti O.; Saario, Susanna M.; Nevalainen, Tapio; Koskinen, Ari M.P.; Poso, Antti
2010 in CHEMMEDCHEM (John Wiley and Sons Ltd)
ISSN: 1860-7179

Asymmetric organocatalytic Michael addition of Meldrum's acid to nitroalkenes: probing the mechanism of bifunctional thiourea organocatalysts

Kataja, Antti O.; Koskinen, Ari M.P.
2010 in ARKIVOC (Arkat USA)
ISSN: 1551-7004

Conformational ensembles of flexible beta-turn mimetics in DMSO-d(6)

Koivisto, Jari J.; Kumpulainen, Esa T.T.; Koskinen, Ari M.P.
2010 in ORGANIC AND BIOMOLECULAR CHEMISTRY (ROYAL SOC CHEMISTRY)
ISSN: 1477-0520

A short and efficient synthesis of (2S,3S,4S)-tert-butyl 3,4-dihydroxy-2-(methoxymethyl)-5-oxopyrrolidine-1-carboxylate

Passiniemi, Mikko; Koskinen, Ari M.P.
2010 in SYNTHESIS: STUTTGART (GEORG THIEME VERLAG KG)
ISSN: 0039-7881

Enantioselective Synthesis of Homosphingosine Derivatives from L-Aspartic Acid

Sauerland, Sami J.K.; Castillo-Melendez, Joel A.; Nattinen, Kalle; Rissanen, Kari; Koskinen, Ari M.P.
2010 in SYNTHESIS: STUTTGART (GEORG THIEME VERLAG KG)
ISSN: 0039-7881

A Simple Organocatalytic Enantioselective Synthesis of Pregabalin

Bassas, Oriol; Huuskonen, Juhani; Rissanen, Kari; Koskinen, Ari M.P.
2009 in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (Wiley-Blackwell)
ISSN: 1434-193X

Towards the total synthesis of Calyculin C: preparation of the C-13-C-25 spirocyclic core

Habrant, Damien; Stewart, Alan J.W.; Koskinen, Ari M.P.
2009 in TETRAHEDRON (PERGAMON-ELSEVIER SCIENCE LTD)
ISSN: 0040-4020

Polyhydroxylated indolizidine alkaloids-synthesis of dideoxycastanospermine

Koskinen, Ari M.P.; Kallatsa, Oili A.; Nissinen, Maija
2009 in TETRAHEDRON (PERGAMON-ELSEVIER SCIENCE LTD)
ISSN: 0040-4020

Catalytic Activity Dependency on Catalyst Components in Aerobic Copper-TEMPO Oxidation

Kumpulainen, Esa T.T.; Koskinen, Ari M.P.
2009 in CHEMISTRY: A EUROPEAN JOURNAL (WILEY-V C H VERLAG GMBH)
ISSN: 0947-6539

The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors

Minkkila, Anna; Myllymaki, Mikko J.; Saario, Susanna M.; Castillo-Melendez, Joel A.; Koskinen, Ari M.P.; Fowler, Christopher J.; Leppanen, Jukka; Nevalainen, Tapio
2009 in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Elsevier Masson SAS)
ISSN: 0223-5234

Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and interaction fields

Myllymaki, Mikko J.; Kasnanen, Heikki; Kataja, Antti O.; Lahtela-Kakkonen, Maija; Saario, Susanna M.; Poso, Antti; Koskinen, Ari M.P.
2009 in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Elsevier Masson SAS)
ISSN: 0223-5234

Highly Chemoselective Copper-Catalyzed Conjugate Reduction of Stereochemically Labile alpha,beta-Unsaturated Amino Ketones

Pelss, Andrejs; Kumpulainen, Esa T.T.; Koskinen, Ari M.P.
2009 in JOURNAL OF ORGANIC CHEMISTRY (AMER CHEMICAL SOC)
ISSN: 0022-3263

Synthesis and agonist properties of novel quinoline and isoquinoline derivatives toward the cannabinoid receptor CB2

Reux, Bastien; Nevalainen, Tapio; Raitio, Katri H.; Koskinen, Ari M.P.
2009 in BIOORGANIC AND MEDICINAL CHEMISTRY (Elsevier Limited)
ISSN: 0968-0896

Synthesis of DEFG ring system of cneorins

Koskinen, Ari M.P.; Pihko, Ainoliisa J.
2008 in ARKIVOC (Arkat USA)
ISSN: 1551-7004

A new application for PyOX-ligands: The asymmetric Henry reaction

Oila, M.J.; Tois, J.E.; Koskinen, A.M.P.
2008 in LETTERS IN ORGANIC CHEMISTRY (Bentham Science Publishers B.V.)
ISSN: 1570-1786

Mild and efficient synthesis of 2-indole-2?-oxazolines at room temperature - A simple access to novel IndOX ligands

Oila, M.J.; Tois, J.E.; Koskinen, A.M.P.
2008 in SYNTHETIC COMMUNICATIONS (Taylor and Francis Ltd.)
ISSN: 0039-7911

Stereoselective total synthesis of pachastrissamine (jaspine B)

Passiniemi, Mikko; Koskinen, Ari M.P.
2008 in Tetrahedron Letters (PERGAMON-ELSEVIER SCIENCE LTD)
ISSN: 0040-4039

Development of bis(2-picolyl)amine-zinc chelates for imidazole receptors

Routasalo, T.; Helaja, J.; Kavakka, J.; Koskinen, A.M.P.
2008 in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (Wiley-Blackwell)
ISSN: 1434-193X

Highly Enantioselective Conjugate Addition of Thiols Using Mild Scandium Triflate Catalysis

Abe, Aki; Sauerland, Sami; Koskinen, Ari
2007 in JOURNAL OF ORGANIC CHEMISTRY (AMER CHEMICAL SOC)
ISSN: 0022-3263

Cleavage of recombinant proteins at poly-His sequences by Co(II) and Cu(II)

Anberg, Martina; Jäntti, Jussi; Heilimo, Saara; Pihkala, Päivi; Paananen, Arja; Koskinen, Ari M.P.; Söderlund, Hans; Linder, Markus
2007 in PROTEIN SCIENCE (Cold Spring Harbor Laboratory Press)
ISSN: 0961-8368

Total Synthesis of Amaminol A: Establishment of the Absolute Stereochemistry

Kumpulainen, Esa; Koskinen, Ari; Rissanen, Kari
2007 in ORGANIC LETTERS (AMER CHEMICAL SOC)
ISSN: 1523-7060

Design, Synthesis, and In Vitro Evaluation of Carbamate Derivatives of 2-Benzoxazolyl- and 2-Benzothiazolyl-(3-hydroxyphenyl)-methanones as Novel Fatty Acid Amide Hydrolase Inhibitors

Myllymäki, Mikko J.; Saario, Susanna M.; Kataja, Antti O.; Castillo-Melendez, Joel A.; Nevalainen, Tapio; Juvonen, Risto O.; Järvinen, Tomi; Koskinen, Ari M.P.
2007 in JOURNAL OF MEDICINAL CHEMISTRY (American Chemical Society)
ISSN: 0022-2623

A rapid method for the preparation of 2-substituted oxazolo[4,5-b]pyridines using microwaveassisted direct condensation reactions

Myllymäki, Mikko; Koskinen, Ari
2007 in Tetrahedron Letters (PERGAMON-ELSEVIER SCIENCE LTD)
ISSN: 0040-4039

Chirally modified gold nanoparticles: nanostructured chiral ligands for catalysis

Koskinen, Ari M.P.; Oila, Markku J.
2006 in ARKIVOC (Arkat USA)
ISSN: 1551-7004

Novel Crown Ether and Salen Metal Chelation Driven Molecular Pinsers

Koskinen, Ari M.P.; Abe, Aki M.M.; Helaja, Juho
2006 in ORGANIC LETTERS (AMER CHEMICAL SOC)
ISSN: 1523-7060

Aza-Michael Additions on a,b-unsaturated esters catalysed by bismuth (III) triflate in conventional chemistry and under microwave irradiation

Koskinen, Ari M.P.; Monfray, Jeremy
2006 in LETTERS IN ORGANIC CHEMISTRY (Bentham Science Publishers B.V.)
ISSN: 1570-1786

Enenatioselective Michael additions on a,b-unsaturated N-acylated oxazolidin-2-ones using mild scandium triflate catalysis

Koskinen, Ari M.P.; Sauerland, Sami J.K.; Kiljunen, Eero
2006 in Tetrahedron Letters (PERGAMON-ELSEVIER SCIENCE LTD)
ISSN: 0040-4039

Development of Dpa-based imidazole zinc anion receptors

Koskinen, Ari M.P.; Salo, Taina M; Helaja, Juho
2006 in Tetrahedron Letters (PERGAMON-ELSEVIER SCIENCE LTD)

a-methylated derivatives of 2-arachidonyl glycerol: Synthesis, CB1 receptor activity and enzymatic stability

Parkkari, Teija; Koskinen, Ari M.P.; Myllymäki, Mikko; Savinainen, Juha R.; Saario, Susanna M.; Castillo-Melendez, Joel A.; Laitinen, Jarmo T.; Nevalainen, Tapio; Järvinen, Tomi
2006 in Bioorganic & Medicinal chemistry letters (PERGAMON-ELSEVIER SCIENCE LTD)

Diastereoselective formation of highly functionalized a-substituted amino acid derivatives via aldol addition

Brunner, Martin; Nissinen, Maija; Rissanen, Kari; Straub, Thomas; Koskinen, Ari M.P.
2005 in JOURNAL OF MOLECULAR STRUCTURE (Elsevier Science B.V.)
ISSN: 0022-2860

Synthesis of a novel carboxy functionalized PyOX-ligand

Koskinen, Ari M.P.; Oila, Markku J.; Tois, Jan E.
2005 in Tetrahedron Letters (PERGAMON-ELSEVIER SCIENCE LTD)

Novel and convienient synthesis of 4(1H)quinolones

Koskinen, Ari M.P.; Tois, Jan; Vahermo, Mikko
2005 in Tetrahedron Letters (PERGAMON-ELSEVIER SCIENCE LTD)

Methyl 3,3,7,7,9-pentamethyl-1,5-dioxaspiro-[5.5]undec-8-ene-8-carbocylate

Koskinen, Ari M.P.; Laitinen, Risto S.; Oilunkaniemi, Raija; Savilampi, Satu K.; Toivola, Reijo J.
2005 in ACTA CRYSTALLOGRAPHICA SECTION E : STRUCTURE REPORTS ONLINE (International Union of Crystallography)

The Reaction Mechanism of Spirocylization and Stereoselectivity Studies for the Calyculin C16-C25 Fragment

Koskinen, Ari M.P.; Rauhala, Vesa; Nättinen, Kalle; Rissanen, Kari
2005 in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (Wiley-Blackwell)

Hitsaajan henkilökohtaisen altistuksen vähentäminen puhallinmaskeilla

Koskinen, Ari; Kasurinen, Heikki; Hänninen, Hannu
2005 in HITSAUSTEKNIIKKA (Wiley-Blackwell)

Locked Conformations for Proline Pyrrolidine Ring: Synthesis and Conformational Analysis of cis- and trans-4-tert-4Butylprolines

Koskinen, Ari M.P.; Helaja, Juho; Kumpulainen, Esa T.T.; Koivisto, Jari; Mansikkamäki, Heidi; Rissanen, Kari
2005 in JOURNAL OF ORGANIC CHEMISTRY (AMER CHEMICAL SOC)

Ligand creation via linking - a rapid and convenient method for construction of novel supported PyOX-ligands

Koskinen, Ari M.P.; Oila, Markku J.; Tois, Jan E.
2005 in TETRAHEDRON (PERGAMON-ELSEVIER SCIENCE LTD)

MFI®-suodatinteknologia hitsaushuurujen poistamiseen

Koskinen, Ari; Santasalo, Juha; Kasurinen, Heikki; Hänninen, Hannu
2005 in HITSAUSTEKNIIKKA (PERGAMON-ELSEVIER SCIENCE LTD)

Polyketide stereotetrads in natural products

Koskinen, Ari M.P.; Karisalmi, Kaisa
2005 in CHEMICAL SOCIETY REVIEWS (Royal Society of Chemistry)
ISSN: 0306-0012

Preparation of Bicyclo[4.3.0.]nonanes by an Organocatalytic Intramolecular Diels-Alder Reaction

Koskinen, Ari M.P.; Selkälä, Sami A.
2005 in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (Wiley-Blackwell)

Syntesis of propellane-containing natural products

Koskinen, Ari M.P.; Pihko, Ainoliisa J.
2005 in TETRAHEDRON (PERGAMON-ELSEVIER SCIENCE LTD)

Model Studies Towards Alternative Cross-Linking of Unsaturated Polyesters

Straub, Thomas; Brunner, Martin; Koskinen, Ari M.P.
2005 in LETTERS IN ORGANIC CHEMISTRY (Bentham Science Publishers B.V.)

Synthesis and molecular structure of (n5-pentamethyl-cyclopentadienyl) (n5-cyclopentadienyl) hexacarbonyl molybdenum tungsten

Straub, Thomas; Haukka, Matti; Brunner, Martin; Koskinen, Ari M.P.; Pakkanen, Tapani A.
2005 in JOURNAL OF ORGANOMETALLIC CHEMISTRY (Elsevier Science)
ISSN: 0022-328X

Model Studies towards emission-free cross-linking of unsaturated polyester resins

Straub, Thomas; Koskinen, Ari M.P.
2005 in Polymer Preprints (Elsevier Science)

Stereoselective synthesis of the C9-C19 lactone-dipropionate fragment of caliculin C

Koskinen, Ari M.P.; Karisalmi, Kaisa
2004 in Tetrahedron Letters (PERGAMON-ELSEVIER SCIENCE LTD)

Highly diastereoselective aldol additions to five-ring N,O-acetals

Koskinen, Ari M.P.; Brunner, Martin
2004 in Tetrahedron Letters (PERGAMON-ELSEVIER SCIENCE LTD)
ISSN: 0040-4039

Enantioselective synthesis of a hindered furyl substituted allyl alcohol intermediate: a case study in asymmetric synthesis

Koskinen, Ari M.P.; Pihko, Ainoliisa J.; Lundell, Katri; Kanerva, Liisa
2004 in TETRAHEDRON-ASYMMETRY (Elsevier Limited)
ISSN: 0957-4166

Stereoselective a-alkylation of fully protected L-serine

Koskinen, Ari M.P.; Saarenketo, Pauli; Straub, Thomas
2004 in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (Wiley-Blackwell)

Biology and Chemistry of Sphingosine-Related Metabolies

Koskinen, Ari M.P.; Brunner, Martin
2004 in CURRENT ORGANIC CHEMISTRY (Bentham Science Publishers B.V.)
ISSN: 1385-2728

An expedient synthesis of spiroketals: model studies for the calylucin C16-C25 fragment

Koskinen, Ari; Rauhala, Vesa; Nevalainen, Marta
2004 in TETRAHEDRON (PERGAMON-ELSEVIER SCIENCE LTD)

Highly Diastereoselective Methylation of Five-Ring N,O-Acetals

Koskinen, Ari M.P.; Brunner, Martin; Straub, Thomas; Saarenketo, Pauli; Rissanen, Kari
2004 in LETTERS IN ORGANIC CHEMISTRY (Bentham Science Publishers B.V.)
ISSN: 1570-1786

Studies towards the synthesis of the C9-C20 lactone-dipropionate fragment of calyculin C

Koskinen, Ari M.P.; Karisalmi, Kaisa
2004 in SYNTHESIS (Bentham Science Publishers B.V.)

Synthesis, in Vitro Evaluation, and Antileishmanial Activity of Water-Soluble Prodrugs of Buparvaquone

Mäntylä, Antti; Garnier, Tracy; Rautio, Jarkko; Nevalainen, Tapio; Vepsäläinen, Jouko; Koskinen, Ari; Croft, Simon L.; Järvinen, Tomi
2004 in Journal of Medical Chemistry (Bentham Science Publishers B.V.)

Model Studies on a diastereoselective synthesis of the C(33)- C(37) fragment of Amphotericin B

Karisalmi, K.; Koskinen, A.M.P.; Nissinen, M.; Rissanen, K.
2003 in TETRAHEDRON (PERGAMON-ELSEVIER SCIENCE LTD)

An enantioselective synthesis of the C(33)- C(37) fragment of Amphotericin B

Karisalmi, Kaisa; Rissanen, Kari; Koskinen, Ari M.P.
2003 in ORGANIC AND BIOMOLECULAR CHEMISTRY (ROYAL SOC CHEMISTRY)
ISSN: 1477-0520

Polyhydroxylated indolizidine alkaloids - an efficient synthesis os 1-deoxy-8, 8a-epi-castanospermine

Koskinen, A.M.P.; Kallatsa, O.A.
2003 in TETRAHEDRON (PERGAMON-ELSEVIER SCIENCE LTD)

Synthetic Approaches towards Indoles on Solid phase - Recent Advances and Future Directions

Tois, J.; Franzen, R.; Koskinen, A.M.P.
2003 in TETRAHEDRON (PERGAMON-ELSEVIER SCIENCE LTD)

Solid-phase lithiation of 5-carboxyindoles

Tois, J.; Koskinen, A.M.P.
2003 in Tetrahedron Letters (PERGAMON-ELSEVIER SCIENCE LTD)

Total Synthesis of nor-1,6-Germacradion-5-ols

Nevalainen, M.; Koskinen, A.M.P.
2002 in JOURNAL OF ORGANIC CHEMISTRY (AMER CHEMICAL SOC)

Asymmetric Organocatalytic Diels-Alder Reactions on Solid Support

Selkälä, S.A.; Tois, J.; Pihko, P.M.; Koskinen, A.M.P.
2002 in ADVANCED SYNTHESIS AND CATALYSIS (Wiley-VCH Verlag)
ISSN: 1615-4150

Catalytic Oxidation of THF with homo and hetero metallic Mo/Ru complexes and molecular oxygen

Straub, Thomas; Koskinen, Ari
2002 in INORGANIC CHEMISTRY COMMUNICATIONS (Elsevier BV)
ISSN: 1387-7003

A short and convenient way to produce Taxol A-ring utilizing the Shapiro-reaction

Törmäkangas, O.P.; Toivola, R.J.; Karvinen, E.K.; Koskinen, A.M.P.
2002 in TETRAHEDRON (PERGAMON-ELSEVIER SCIENCE LTD)

The Tischenko Reaction and its Modifications in Organic Synthesis

Törmäkangas, O.P.; Koskinen, A.M.P.
2002 in Rec. Rex. Dev. Org. Chem. (PERGAMON-ELSEVIER SCIENCE LTD)

Selective Mixed Tishchenko Reaction via Substituted 4-Hydroxy-1,3-Dioxanes

Törmäkangas, O.P.; Saarenketo, P.; Koskinen, A.M.P.
2002 in ORGANIC PROCESS RESEARCH AND DEVELOPMENT (American Chemical Society)
ISSN: 1083-6160

Computer-assisted discovery of novel amino acid derived sulfides for enantioselective epoxidation of aldehydes

Myllymäki, Vesa T.; Lindvall, Mika K.; Koskinen, Ari M.P.
2001 in TETRAHEDRON (PERGAMON-ELSEVIER SCIENCE LTD)

The hydrogenation of (4R)-4[(tert-Butoxycarbonyl)amino]-2-methyl-2-penten-5-olide: A Precursor of trans-4-Methylproline

Nevalainen, Marta; Koskinen, Ari M.P.
2001 in SYNLETT (Georg Thieme Verlag)

Synthesis of a 10-Membered Carbocycle By Olefin Metathesis

Nevalainen, Marta; Koskinen, Ari M.P.
2001 in ANGEWANDTE CHEMIE (Wiley-VCH Verlag GmbH & Co. KGaA)

Synthesis of Fmoc-Protected trams-4-Methylproline

Nevalainen, Marta; Kauppinen, Pasi M.; Koskinen, Ari M.P.
2001 in JOURNAL OF ORGANIC CHEMISTRY (AMER CHEMICAL SOC)

An expedient synthesis of D-callipeltose

Pihko, Ainoliisa J.; Nicolaou, K.C.; Koskinen, Ari M.P.
2001 in TETRAHEDRON-ASYMMETRY (Elsevier Limited)
ISSN: 0957-4166

Hydrogenation of 4-deoxy-beta-L-threo-hex-4-enopyranosyluronic acid sodium salt attached to xylodiose or xylotriose

Selkälä, Sami A.; Alakurtti, Sami; Koskinen, Ari M.P.
2001 in Tetrahedron Letters (PERGAMON-ELSEVIER SCIENCE LTD)

Fast Aldol-Tishchenko Reactions Utilizing 1,3-Diol Monoalcoholates as the Catalysts

Törmäkangas, Olli P.; Koskinen, Ari M.P.
2001 in ORGANIC PROCESS RESEARCH AND DEVELOPMENT (American Chemical Society)
ISSN: 1083-6160

The Tishchenko reaction and its modifications in organic synthesis

Törmäkangas, Olli P.; Koskinen, Ari M.P.
2001 in Recent Res. Devel. Organic Chem. (American Chemical Society)

Monoalcoholates of 1,3-diols as effective catalysts in the Tishchenko esterification of 1,3-dioxan-4-ols

Törmäkangas, Olli P.; Koskinen, Ari M.P.
2001 in Tetrahedron Letters (PERGAMON-ELSEVIER SCIENCE LTD)

The first synthesis of bicyclo[4.2.0]oct-1(6)-en-7-one

Koskinen, A.; Toivola, R.; Savilampi, S.
2000 in Tetrahedron Letters (PERGAMON-ELSEVIER SCIENCE LTD)

2-Thioanyldichlorophosphine, new starting material for the preparation of multidentate phosphine ligands: syntheses and characterisation of derivatives of 2-anisyl- and 2-thioanisyldichlorophosphines

Laitinen, R.H; Heikkinen, V.; Haukka, M.; Koskinen, A.M.P.; Pursiainen, J.
2000 in J. Organomet. Chem. (PERGAMON-ELSEVIER SCIENCE LTD)

Hajos-Parrish ketone: approaches toward C-ring prcursors of 7-deoxytaxol

Lajunen, M.; Koskinen, A.
2000 in Journal Chem. Soc., Perkin Trans. (PERGAMON-ELSEVIER SCIENCE LTD)

Co(II) Catalysed Oxidation of alpha-Pinene by Molecular Oxygen.Part 2

Lajunen, M.; Maunula, T.; Koskinen, A.
2000 in TETRAHEDRON (PERGAMON-ELSEVIER SCIENCE LTD)

Review article, Literature review, Systematic review

Harmicine, a Tetracyclic Tetrahydro-ß-Carboline: From the First Synthetic Precedent to Isolation from Natural Sources to Target-Oriented Synthesis (Review)

Lood, C.S.; Koskinen, A.M.P.
2015 in CHEMISTRY OF HETEROCYCLIC COMPOUNDS (Springer New York)
ISSN: 0009-3122

Pharmacological Importance of Optically Active Tetrahydro-beta-carbolines and Synthetic Approaches to Create the C1 Stereocenter

Laine, Aino E.; Lood, Christopher; Koskinen, Ari M.P.
2014 in MOLECULES (Springer New York)

Conference proceedings

Conformational Control in Chemical Reactions and Recognition

Koskinen, Ari M.P.
2008
ISBN: 978-9955-33-265-7

Conformational Control in Stereoselective Synthesis

Koskinen, Ari M.P.
2008

Total Synthesis of Amaminols

Kumpulainen, Esa T.T.; Koskinen, Ari M.P.
2008

Progress in the Asymmetric Synthesis of Calyculins and Related Natural Products

Koskinen, Ari M.P.
2006

Locked Conformations for Proline Pyrrolidine Ring: Synthesis and Conformational Analysis of Cis- and Trans-4-Tert-Butylprolines

Kumpulainen, E.T.T; Helaja, J.; Koivisto, J.; Koskinen, A.M.P.; Mansikkamäki, H.; Rissanen, Kari
2006
ISBN: 951-9223-50-9

Total Synthesis of Pachastrissamine (Jaspine B) and its Epimers

Passiniemi, Mikko; Koskinen, Ari M.P.
2006

Hitsaamon pienhiukkaset

Kasurinen, Heikki; Koskinen, Ari; Hänninen, Hannu
2004

Asymmetric Synthesis of Natural Products

Koskinen, Ari M.P.
2004

Internal Asymmetric Induction in Total Synthesis of Natural Products

Koskinen, Ari M.P.
2003

Internal Asymmetric Induction in Total Synthesis

Koskinen, Ari M.P.
2003

Internal Asymmetric Induction in Total Synthesis

Koskinen, A.M.P.
2002

New Strategies in Natural Product Synthesis

Koskinen, A.M.P.
2002

Green Chemistry by use of Mo/Ru Catalysts: THF and Oxygen Yield y-butyrolactone and Water

Straub, Thomas; Koskinen, Ari
2002

Group 6 / Group 8 Homo- and Hetero Bimetallic Complexes: Active Catalysts/Catalyst Precursors for Several Processes

Straub, Thomas; Koskinen, Ari
2002

Non-refereed scientific articles

Book section

tert-Butyl 4-formyl-2,2-dimethyloxazolidine-3-carboxylate

Koskinen, Ari
2013
ISBN: ?

Publications intended for professional communities

Article in professional journal

Synteettisen orgaanisen kemian haasteita seuraavalle vuosisadalle

Koskinen, Ari M.P.
2004 in Suomalainen tiedeakatemia, vuosikirja (JOHN WILEY & SONS)

Hitsaamon pienhiukkaset

Koskinen, Ari; Kasurinen, Heikki; Ukkonen, A.; Hänninen, Hannu
2004 in HITSAUSTEKNIIKKA (JOHN WILEY & SONS)

Tervan kemiallinen ihmemaa

Koskinen, Ari M.P.
2004 in Suomalainen hautaterva, Rakennusperinteen ystävät ry (JOHN WILEY & SONS)

Published development or research report

Studies towards the total synthesis of Pyloricidins

Abe, Aki M.; Koskinen, Ari M.P.
2008

Studies towards the total synthesis of Pyloricidins

Abe, Aki M.; Koskinen, Ari M.P.
2008

Total Synthesis of Amaminol A

Kumpulainen, Esa T.T.; Koskinen, Ari M.P.
2008

4-substituted phenololic N-Alkyl carabamates as Faah and MGL inhibitors

Minkkilä, A.; Myllymäki, Mikko J.; Käsnänen, H.; Saario, S.M.; Koskinen, Ari M.P.; Poso, A.; Nevalainen, T.
2008

The Synthesis and Biological evaluation of 4 substituted phenolic N-alkyl carabamates as novel faah MGL inhibitors

Minkkilä, Anna; Myllymäki, Mikko J.; Käsnänen, Heikki; Saario, Susanna M.; Koskinen, Ari M.P.; Poso, Antti; Nevalainen, Tapio
2008

Copper catalayzed reduction of a,ßunsaturated ketones containing epimerizable stereocenters

Pelss, Andrejs; Koskinen, Ari M.P.
2008

Demethylation of aromatic ethers using ionic liquids in microwave reactor

Vuokko, Juha; Passiniemi, Mikko; Myllymäki, Mikko; Koskinen, Ari M.P.
2008

Dmethylation of aromatic ethers using ionic liquids in microwave reactor

Vuokko, Juha; Passiniemi, Mikko; Myllymäki, Mikko; Koskinen, Ari M.P.
2008

Novel Crown Ether and Salen Metal Chelation Driven Molecular Pincers

Abe, Aki; Helaja, Juho; Koskinen, Ari
2007

Novel Crown Ether and Salen Metal Chelation Driven Molecular Pincers

Abe, Aki; Helaja, Juho; Koskinen, Ari
2007

Chiral Oxazoline Derivatives of Phenyl Crabamates as Potential FAAH-Inhibitors

Kataja, Antti O.; Myllymäki, Mikko J.; Koskinen, Ari M.P.
2007

Total synthesis of Amaminol A

Kumpulainen, Esa; Koskinen, Ari
2007

Development of Novel Asymmetric Methods for The Synthesis of Alpha-Aminoacid Containing Sphingolipids

Tammisto, Aapo; Koskinen, Ari M.P.
2007

Aza-Michael Addition Reactions to a,b-Unsaturated Esters with Catalytic Scandium (III) Triflate

Bassas, Oriol; Koskinen, Ari M.P.
2006

Hitsaamon pienhiukkaset - Fine Particles in Welding Workshop

Koskinen, Ari; Hänninen, Hannu
2006

Hitsaamon pienhiukkaset

Koskinen, Ari; Kasurinen, Heikki; Hänninen, Hannu
2006

Hitsaushuurun vähentäminen teollisuudessa

Koskinen, Ari; Schimberg, R.; Hänninen, Hannu
2006

Studies Torwards the Total Synthesis of Amaninol A

Kumpulainen, E.T.T.; Koskinen, A.M.P.
2006

A Rapid Method for the Preparation of 2-substituted-oxazolo[4,5-b]Pyridines using Microwave-assisted Direct Condensation Reactions

Myllymäki, Mikko J.; Koskinen, Ari M.P.
2006

Preparation of Some 2-Aryl Subtituted Oxazoles Via Condensation Reactions with and without Microwave Irradiation

Myllymäki, M.J.; Koskinen, A.M.P.
2006

Applications of the PyOX-Core in the Field of Asymmetric Catalysis

Oila, M.J.; Tois, J.E.; Koskinen, Ari M.P.
2006

Studies Towards the Stereoselective Synthesis of Anhydrophytosphingosine Pachastrissamine (Jaspine B)

Passiniemi, Mikko; Koskinen, Ari M.P.
2006

Studies Towards the Synthesis of 6-amino-and Azasugars

Passiniemi, Mikko; Koskinen, A.M.P.
2006

Towards the total synthesis of calyculin C

Stewart, Alan J.W.; Koskinen, Ari M.P
2006

Synthesis of C2- Symmetric Chiral Diazacrown Ethers

Tammisto, A.A.; Passiniemi, Mikko.; Koskinen, A.M.P.
2006

Hitsaushuurun pienhiukkaset ja niiden terveydelliset vaikutukset

Keränen, Marko; Kasurinen, Heikki; Koskinen, Ari; Hänninen, Hannu
2005

Organocatalytic heteroatom asymmetric Michael additions

Koskinen, Ari M.P.; Monfray, J.
2005

Hitsaajan pienhiukkasaltistuksen vähentäminen

Koskinen, Ari
2005

Synthesis of 4-tert-Butyl Prolines

Koskinen, Ari M.P.; Kumpulainen, Esa T.T.; Helaja, Juho
2005

Progress towards synthesis of defg ring system of Cneorin C

Koskinen, Ari M.P.; Pihko, Ainoliisa
2005

Synthesis of 2-Benzoxazolyl- and 2-Benzothiazolyl-(3-Hydroxyphenyl)Methanones

Myllymäki, Mikko M.; Castillo, Joel A.; Koskinen, Ari M.P.
2005

First generation of novel nitroguanidines and fatty compounds

Castillo Melendez, Joel; Jaimes, A.; Myllymäki, M.J.; Rodriguez, M.; Koskinen, Ari M.P.
2004

Synthesis of novel monoglyceride lipase (MGL) inhibitors

Castillo Melendez, Joel; Saario, S.; Salo, O.; Nevalainen, T.; Poso, A.; Järvinen, T.; Koskinen, Ari M.P.
2004

Solvent-free or in plain water - Mo/Ru-catalysed, selective oxygenation of cyclic ethers

Koskinen, Ari M.P.; Straub, Thomas
2004

Progress towards synthesis of DEFG ring system of cneorin C

Koskinen, Ari M.P.; Pihko, Ainoliisa
2004

Nanomaterials - A Risk to Health at Work?

Lähde, T.; Hämeri, K.; Kasurinen, Heikki; Koskinen, Ari; Ukkonen, A.
2004

Synthesis of the C9-C20 dipropionate-lactone fragment of Calyculin C

Karisalmi, K.; Koskinen, A.M.P.
2003

Komppa Centenary Symposium, July 6-9, Espoo, Finland

Koskinen, A.M.P.; Koskinen, J.P.; Karjalainen, T.M.
2003

Better performance in HDS through hetero bimetallic complexes

Straub, T.; Koskinen, A.M.P.
2003

Co-operative effects in bimetallic compounds - who is doing the trick?

Straub, T.; Koskinen, A.M.P.
2003

Stereoselective aldol addition to five-ring N,O -acetals

Brunner, Martin; Koskinen, Ari
2002

Synthesis, Reactivity and Catalytic Studies on Cp*/Cp(Co)3M-M(CO)3Cp/Cp* Complexes

Miravent Tavares, Zara; Koskinen, Ari; Straub, Thomas
2002

New Synthons for the Synthesis of L(PMe3)1/0(CO)2/3M-M'(PMe3)1/0(CO)1/2L Complexes

Miravent Tavares, Zara; Koskinen, Ari; Straub, Thomas
2002

Synthetic studies towards the total synthesis of attenols a and b

Oila, Markku; Koskinen, Ari
2002

Y-Butyrolactone and Water from THF and Oxygen: Green Chemistry with Mo/Ru Catalysts

Straub, Thomas; Koskinen, Ari
2002

Text book or professional handbook or guidebook or dictionary

Asymmetric Synthesis of Natural Products

Koskinen, Ari
2012
ISBN: 978-1-1199-7668-4

Patents and invention disclosures

Patent

Method for cleaving proteins at a engineered specific site with free metal ions

Linder, Markus; Jäntti, Jussi; Söderlund, Hans; Helaja, Juho; Koskinen, Ari M.P.
2005

A method for alternative cross-linking of unsaturated polyesters via catalytic alkyne coupling

Straub, Thomas; Koskinen, Ari M.P.
2005

Method for catalytic oxygenation of cyclic ethers with homo hetero metallic Mo/Ru complexes and molecular oxygen

Straub, Thomas; Koskinen, Ari M.P.
2004

Menetelmä saturoimattomien polymeerien ristisitomiseksi katalyyttisellä alkyynikytkennällä

Straub, Thomas; Koskinen, Ari M.P.
2004

Erratum: Synthesis of (S)- and (R)-Harmicine from Proline An Approach Toward Tetrahydro-beta-carbolines

Lood, Christopher S.; Koskinen, Ari M. P.
2014

Development of a proof-of-concept small molecule inhibitor of MgcRacGAP identifies new potential functions of MgcRacGAP in cell division and signaling

van Adrichem, A.; Fagerholm, A.; Turunen, L.; Lehto, A.; Saarela, J.; Koskinen, A.; Repasky, G.; Wennerberg, K.
2014 in MOLECULAR BIOLOGY OF THE CELL (AMER SOC CELL BIOLOGY)
ISSN: 1059-1524

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