Alberto Serrano-Pozo

Education

• PhD University of Seville School of Medicine (Spain) 2013
• Research Fellowship in Dementias University Hospital Virgen del Rocío, Seville (Spain) 2008
• Neurologist University of Iowa, Iowa city 2017
• MD University of Mlaga-Spain 2001
• Fellowship in Clinical Dementias Massachusetts General Hospital 2018
• Neurologist University Hospital Virgen del Rocío, Seville (Spain) 2006

Companies

• Assistant Professor of Neurology Harvard Medical School (2021)
• Assistant in Neurology Massachusetts General Hospital (2018)
• Instructor in Neurology Harvard Medical School (2018 — 2021)
• John H. Growdon Fellow in Dementias Massachusetts General Hospital (2017 — 2018)
• Neurology Resident Physician University of Iowa Hospitals & Clinics (2013 — 2017)
• Research Fellow in Neurology Massachusetts General Hospital (2008 — 2013)
• Research Fellow in Neurology Hospital Universitario Virgen del Rocío, Seville, Spain (2006 — 2008)
• Neurology Resident Physician Hospital Universitario Virgen del Rocío, Seville, Spain (2002 — 2006)

Research Interests

alzheimer's disease; astrocytes; dementia with lewy bodies; dementias; microglia; neurodegeneration; neurodegenerative diseases; neurofibrillary tangles; neurology; plaque amyloid; tau proteins; tauopathies

Selected Publications:

• Serrano-Pozo A, Qian J, Monsell SE, Frosch MP, Betensky RA, Hyman BT. Examination of the clinico-pathologic continuum of Alzheimer disease in the autopsy cohort of the National Alzheimer Coordinating Center. J Neuropathol Exp Neurol 2013; 72(12): 1182-1192. [PMCID: PMC3962953]
• Serrano-Pozo A, Qian J, Monsell SE, Blacker D, Gómez-Isla T, Betensky RA, Growdon JH, Johnson K, Frosch MP, Sperling RA, Hyman BT. Mild to moderate Alzheimer dementia with insufficient neuropathological changes. Ann Neurol 2014; 75(4): 597-601. [PMCID: PMC4016558]
• Serrano-Pozo A, Qian J, Muzikansky A, Monsell SE, Montine TJ, Frosch MP, Betensky RA, Hyman BT. Thal amyloid stages do not significantly impact the correlation between neuropathological change and cognition in the Alzheimer disease continuum.J Neuropathol Exp Neurol 2016; 75(6): 516-26. [PMCID: PMC6250207]
• Serrano-Pozo A, Qian J, Monsell SE, Betensky RA, Hyman BT. APOEe2 is associated with milder clinical and pathological Alzheimer’s disease. Ann Neurol 2015; 77(6): 917-929. [PMCID: PMC4447539]
• Qian J, Betensky RA, Hyman BT, Serrano-Pozo A. Association of APOE genotype with heterogeneity of cognitive decline rate in Alzheimer’s disease. Neurology 2021 (in press).
• Serrano-Pozo A, Mielke ML, Gómez-Isla T, Betensky RA, Growdon JH, Frosch MP, Hyman BT. Reactive glia not only associates with plaques but also parallels tangles in Alzheimer’s disease. Am J Pathol 2011; 179(3): 1373-1384. [PMCID: PMC3157187]
• Serrano-Pozo A, Gómez-Isla T, Growdon JH, Frosch MP, Hyman BT. A phenotypic change but not proliferation underlies glial responses in Alzheimer disease. Am J Pathol 2013; 182(6): 2332-2344. [PMCID: PMC3668030]
• Gui Y, Marks JD, Das S, Hyman BT, Serrano-Pozo A. Characterization of the 18 kDa translocator protein (TSPO) in post-mortem normal and Alzheimer’s brains. Brain Pathol 2020; 30(1): 151-164. [PMCID:PMC6904423]
• Das S*, Li Z*, Noori A, Hyman BT, Serrano-Pozo A. Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration. J Neuroinflammation 2020; 17(1): 227. [PMCID: PMC7393869]
• Noori A, Mezlini AM, Hyman BT, Serrano-Pozo A*, Das S*. Systematic review and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across neurodegeneration. Neurobiol Dis 2021; 149: 105225. [PMCID: PMC7856076]
• Serrano-Pozo A, Das S, Hyman BT. APOE and Alzheimer’s disease: advances in genetics, pathophysiology, and therapeutic approaches. Lancet Neurol 2021; 20(1): 68-80.